2007
DOI: 10.1186/1475-2891-6-43
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Diacylglycerol oil for the metabolic syndrome

Abstract: Excess adiposity has been shown to play a crucial role in the development of the metabolic syndrome. The elevated fasting and postprandial triglyceride-rich lipoprotein levels is the central lipid abnormality observed in the metabolic syndrome. Recent studies have indicated that diacylglycerol (DAG) is effective for fasting and postprandial hyperlipidemia and preventing excess adiposity by increasing postprandial energy expenditure. We will here discuss the mechanisms of DAG-mediated improvements in hyperlipid… Show more

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Cited by 65 publications
(39 citation statements)
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“…Despite the equivalent energy value and digestibility for both DAG and TAG, extensive researches demonstrate that DAG, particularly 1,3-DAG, is capable of suppressing the accumulation of body fat, reducing the level of serum TAG, decreasing postprandial hyperlipidemia and hemoglobin A1c, increasing postprandial lipid oxidation, and hence reducing body weight (Flickinger and Matsuo 2003;Yanai et al 2007;Rudkowska et al 2005;Tada 2004). Its excellent antiobesity characteristic lies in its different metabolic pathway compared to TAG as illustrated in Fig.…”
Section: Nutrition and Health Effectsmentioning
confidence: 97%
“…Despite the equivalent energy value and digestibility for both DAG and TAG, extensive researches demonstrate that DAG, particularly 1,3-DAG, is capable of suppressing the accumulation of body fat, reducing the level of serum TAG, decreasing postprandial hyperlipidemia and hemoglobin A1c, increasing postprandial lipid oxidation, and hence reducing body weight (Flickinger and Matsuo 2003;Yanai et al 2007;Rudkowska et al 2005;Tada 2004). Its excellent antiobesity characteristic lies in its different metabolic pathway compared to TAG as illustrated in Fig.…”
Section: Nutrition and Health Effectsmentioning
confidence: 97%
“…Upregulated mRNA expressions associated with FFA transport (FFA translocase and FFA binding protein), b-oxidation (acyl-CoA oxidase and medium-chain acyl-CoA dehydrogenase) and thermogenesis (uncoupling protein-2) in the small intestine by DAG may explain in part mechanisms for increased postprandial energy expenditure [101]. Based on these observations, it is suggested that DAG can be used as a therapeutic agent for the treatment of MetS [102].…”
Section: Diacylglycerol In Metabolic Syndrome and Neurological Disordersmentioning
confidence: 99%
“…Apesar de similar ao triacilglicerol (TAG), o diacilglicerol (DAG) tem a capacidade de reduzir o nível de lipídios pósprandial, auxiliar na redução de peso e evitar o acúmulo de gordura abdominal (Cheong et al, 2007, Kruguer et al, 2011Valério, et al, 2009;Fregolente et al, 2009). O diacilglicerol pode ser produzido através de processos de esterificação de glicerol, glicerólise de triacilgliceróis ou hidrólise parcial de triacilglicerois (Kristensen et al, 2005;Yanai et al, 2007, Castro et al, 2004, e no entanto é preciso que esta quantidade seja controlada para que não aconteça inibição da atividade enzimática por excesso de água (Matos et al, 2011;Pawongrat et al, 2007). Uma forma de reduzir os efeitos negativos da concentração de água, durante a hidrólise enzimática, é o emprego de sistema batelada alimentada.…”
Section: Introductionunclassified