Diagnosing and treating chronic musculoskeletal pain based on the underlying mechanism(s)

Clauw, Daniel J.

doi:10.1016/j.berh.2015.04.024

Cited by 134 publications

(104 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the case of 'central sensitization,' the normal habituation/sensitization process has been disrupted such that even normal 'afferent noise' can be sensed as being painful. As such, when long-standing acute pain hypersensitizes the CNS, it results in increased pain facilitation pathways and decreased inhibition pathways [32][33][34][35]. This results in pain that does not reduce over time (chronic) and therefore the sufferer is left in a persistent, sensitized state of pain.…”

Section: Discussionmentioning

confidence: 99%

“…This results in pain that does not reduce over time (chronic) and therefore the sufferer is left in a persistent, sensitized state of pain. Central sensitization is now well established as an integral factor in many chronic pain states, including the commonly occurring knee and back pain [32,34,35]. Since peripheral information plays a crucial role in central sensitization, the key to reversing central sensitization, and moving the system out of the pain state, also lies in providing new peripheral information [33].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An Over-the-Counter Central Sensitization Therapy: A Chronic Back Pain Registry Study of Pain Relief, Medication Use and Their Adverse Effects

2016

View full text Add to dashboard Cite

aim: Back pain, the most prevalent musculoskeletal chronic pain condition, is usually treated with analgesic medications of questionable efficacy and frequent occurrence of adverse side effects. objective: The objective was to determine the effectiveness of the ActiPatch medical devices in reducing chronic back pain, document medication related adverse side effects and establish their impact on quality of life. methods: Upon completing a 7-day trial, subjects were contacted via email with an assessment form using the Constant Contact email program. A total of 1394 responses were collected from subjects who used the device for back pain. Conclusion: Medication adverse effects are common and impact quality of life in the lay population. ActiPatch is an effective intervention for the majority of subjects for treating chronic back pain, although this requires further investigation in randomized clinical trials. • Subjects in this study had chronic back pain (CBP), with a mean pain duration averaging 6.1 years.• Pain etiologies demonstrated a heterogeneous subject population of CBP sufferers.• About 96% of the subjects were using analgesics medications averaging 2.5 per subject, with 71% using prescription analgesics.• The majority of individuals using analgesic medications for CBP report less than adequate pain relief.• Adverse effects from pain medications are common (66%) for CBP sufferers.• CBP sufferers, who report chronic pain for longer than 2 years, also detail using approximately 25% more prescription analgesics than those who have experienced the pain for less than 2 years.• The number of adverse effects is directly proportional to the number of prescription analgesics being used.• The increase in the number of adverse side effects negatively impacts quality of life.• The majority of CBP users, upon using the ActiPatch®, reported a clinically significant reduction in pain within 7 days.• Nearly 50% of the study subjects were able to eliminate or decrease analgesic medications after 7 days of use of the medical device.• The ActiPatch was effective in reducing CBP for the majority of subjects as well as reducing their analgesic use.For reprint orders, please contact: reprints@futuremedicine.com

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An Over-the-Counter Central Sensitization Therapy: A Chronic Back Pain Registry Study of Pain Relief, Medication Use and Their Adverse Effects

2016

View full text Add to dashboard Cite

show abstract

“…НПВП способны проникать через гемато-энцефалический барьер (за счет свободной, не связанной альбумином фракции) и создавать в ткани ЦНС концент-рацию, достаточную для эффективной блокады ЦОГ2 и подавления синтеза ПГЕ2 [2,3,18]. Экспериментальные работы четко подтверждают обезболивающее действие НПВП, связанное с их влиянием на синтез провоспали-тельных медиаторов в ЦНС [2,3,19,20].…”

Section: парацетамол и нестероидные противовоспалительные препаратыunclassified

“…Неконтролируемая воспалительная реак-ция запускает процесс формирования хронической боли, что связано с феноменами центральной сенситизации и нейропластичности. Становится очевидным, что основ-ным направлением комплексной анальгетической терапии должно быть целенаправленное применение фармаколо-гических средств, обладающих противовоспалительным потенциалом [1][2][3].…”

unclassified

Pain and Inflammation. Part 2. The Analgesic Potential of Anti-Inflammatory Drugs

Каратеев¹,

Каратеев²,

Davydov³

2017

rsp

View full text Add to dashboard Cite

“…Yani bunlarda hem nosiseptif/inflamatuvar hem de nöropatik ağrı ve santral sensitizasyon mekanizmaları rol oynar. [41] Kronik ağrıda yer alan nöropatik ağrı/santral sensitizasyon komponentler nedeniyle, medikal tedavi yaklaşımında bu mekanizmalar da hedeflenmelidir. [41] Farmakoterapide adjuvan analjezikler (antidepresanlar, antikonvülsanlar, topikal ajanlar vb.)…”

Section: Ri̇sk Faktörleri̇unclassified

Ağrının kronikleşmesine neden olan faktörler, patofizyoloji temelli tedaviler

Ünal-Çevik¹

2017

TOTBID

View full text Add to dashboard Cite

Diagnosing and treating chronic musculoskeletal pain based on the underlying mechanism(s)

Cited by 134 publications

References 90 publications

An Over-the-Counter Central Sensitization Therapy: A Chronic Back Pain Registry Study of Pain Relief, Medication Use and Their Adverse Effects

An Over-the-Counter Central Sensitization Therapy: A Chronic Back Pain Registry Study of Pain Relief, Medication Use and Their Adverse Effects

Pain and Inflammation. Part 2. The Analgesic Potential of Anti-Inflammatory Drugs

Ağrının kronikleşmesine neden olan faktörler, patofizyoloji temelli tedaviler

Contact Info

Product

Resources

About