Diagnosing coronary artery disease in diabetic patients

Ashley, Euan A.; Raxwal, Vinod; Finlay, Malcolm; Froelicher, Victor

doi:10.1002/dmrr.297

Cited by 14 publications

(6 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, our patients were not population based, but rather selected, so that silent CAD prevalence was about 50%. In a more realistic situation with a silent CAD prevalence of about 10% to 30%, 8 the positive predictive value may be lower than that found in the present study. Nevertheless, the predictive power of the IIEF-5 questionnaire could be increased when used together with other recognized cardiovascular risk factors.…”

Section: Discussioncontrasting

confidence: 89%

“…1,2,4 -6 An association between overt coronary artery disease (CAD) and ED has been described. 2,5,6 In the diabetic population, the prevalence of silent CAD is particularly high 7,8 ; nevertheless, at the present, the prevalence of ED among diabetic subjects with asymptomatic CAD is unknown. Silent CAD is a strong predictor of coronary events and early death, especially in diabetic patients.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Relationship Between Erectile Dysfunction and Silent Myocardial Ischemia in Apparently Uncomplicated Type 2 Diabetic Patients

et al. 2004

View full text Add to dashboard Cite

Background-Erectile dysfunction (ED) is associated with coronary artery disease (CAD). In diabetic patients, CAD is often silent. Among diabetic patients with silent CAD, the prevalence of ED has never been evaluated. We investigated whether ED is associated with asymptomatic CAD in type 2 diabetic patients. Methods and Results-We evaluated the prevalence of ED in 133 uncomplicated diabetic men with angiographically verified silent CAD and in 127 diabetic men without myocardial ischemia at exercise ECG, 48-hour ambulatory ECG, and stress echocardiography. The groups were comparable for age and diabetes duration. Patients were screened for ED using the validated International Index of Erectile Function (IIEF-5) questionnaire. The prevalence of ED was significantly higher in patients with than in those without silent CAD (33.8% versus 4.7%; Pϭ0.000). Multiple logistic regression analysis showed that ED, apolipoprotein(a) polymorphism, smoking, microalbuminuria, HDL, and LDL were significantly associated with silent CAD; among these risk factors, ED appeared to be the most efficient predictor of silent CAD (OR, 14.8; 95% CI, 3.8 to 56.9). Conclusions-Our study first shows a strong and independent association between ED and silent CAD in apparently uncomplicated type 2 diabetic patients. If our findings are confirmed, ED may become a potential marker to identify diabetic patients to screen for silent CAD. Moreover, the high prevalence of ED among diabetics with silent CAD suggests the need to perform an exercise ECG before starting a treatment for ED, especially in patients with additional cardiovascular risk factors.

show abstract

Section: Discussioncontrasting

confidence: 89%

mentioning

confidence: 99%

Relationship Between Erectile Dysfunction and Silent Myocardial Ischemia in Apparently Uncomplicated Type 2 Diabetic Patients

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Although IGT and IFG are not considered to be “diseases,” they are associated with increased risk of development of overt diabetes mellitus [14], a true risk factor for morbidity, and mortality from CVDs [15]. However, the association between glucose status and the risk of CVDs starts below the diagnostic threshold for diabetes mellitus [6].…”

Section: Discussionmentioning

confidence: 99%

Soluble CD40 Ligand Levels in Otherwise Healthy Subjects With Impaired Fasting Glucose

Taşçı¹,

Doğru²,

Sönmez³

et al. 2006

Mediators of Inflammation

View full text Add to dashboard Cite

Unlike diabetes mellitus and impaired glucose tolerance, it is not clear whether the subjects with impaired fasting glucose (IFG) are at increased risk of atherosclerosis and cardiovascular diseases. The CD40-CD40 ligand interaction is involved in the mechanism of atherosclerosis. We investigated whether soluble CD40L (sCD40L) as well as high sensitive C-reactive protein (hsCRP) levels are increased in subjects with IFG having no confounding factors for inflammation or atherosclerosis. Twenty four IFG subjects with no additional disorders and 40 appropriate healthy controls were studied. sCD40L and hsCRP levels in the IFG and control groups were similar. Blood pressures, total and LDL-cholesterol, and triglyceride levels were also similar, whereas HDL-cholesterol was lower and HOMA-IR indexes were higher in the IFG group. Though the sample size was small, the present data show that sCD40L seems not to alter in subjects with IFG suggesting that it might not be an independent risk factor for atherosclerosis.

show abstract

“…Multiple studies have found that the elderly and those with diabetes have higher rates of silent ischemia [15]. Likewise, patients with CKD have been shown to have higher rates of silent ischemia that cluster with serious arrhythmias and other cardiac events [16].…”

Section: Diagnosis Of Acute Coronary Syndrome In Patients With Chronimentioning

confidence: 98%

Acute coronary syndromes in patients with renal failure

McCullough

2003

Curr Cardiol Rep

View full text Add to dashboard Cite

As the rates of obesity and diabetes continue to rise sharply in the United States, there is a secondary epidemic of diabetic nephropathy, chronic kidney disease, and end-stage renal disease requiring renal replacement therapy. Cardiovascular disease is the leading cause of death in patients with renal disease. Many sources of information support the concept that the metabolic condition caused by renal failure is an independent cardiac risk factor with a direct relationship to the pathogenesis of atherosclerosis, acute coronary syndromes (ACS), heart failure, and arrhythmias. An estimated glomerular filtration rate less than 60 mL/min/1.73 m(2) has consistently been shown to be the most powerful predictor of adverse outcomes in ACS. This paper focuses on ACS and highlights the major issues with respect to diagnosis and treatment in patients with underlying renal failure. Because patients with renal disease are routinely excluded from clinical trials of ACS, we draw upon a variety of clinical data sets to gather an evidenced-based approach to this important and growing population of patients.

show abstract

Diagnosing coronary artery disease in diabetic patients

Cited by 14 publications

References 64 publications

Relationship Between Erectile Dysfunction and Silent Myocardial Ischemia in Apparently Uncomplicated Type 2 Diabetic Patients

Relationship Between Erectile Dysfunction and Silent Myocardial Ischemia in Apparently Uncomplicated Type 2 Diabetic Patients

Soluble CD40 Ligand Levels in Otherwise Healthy Subjects With Impaired Fasting Glucose

Acute coronary syndromes in patients with renal failure

Contact Info

Product

Resources

About