Computer-assisted biomedical imaging and simulation have played essential roles in orthopaedic surgery. In order to achieve much deeper understandings and even better surgical interventions for complex proximal humeral fractures (CPHF), appropriate three-dimensional (3D) bone and joint simulations are expected. In this study, an advanced computer-aided design (CAD) based 3D digitalized reconstruction technique was used to form vivid 3D visualization and simulation of CPHF. Applications of the novel biomedical reconstruction and simulation technique in the special area of bone and joint surgery were elucidated. The clinical outcome of fracture open reduction and internal fixation (ORIF) was improved. Besides, the advantages including declined duration of operation, amount of bleeding and hospital stay were simultaneously revealed (p<0.05). In conclusion, our results suggest that computer-assisted novel 3D reconstruction and simulation substantially improved the surgical outcomes of CPHF.