Diagnosing lung cancer in exhaled breath using gold nanoparticles

Peng, Gang; Tisch, Ulrike; Adams, Orna; Hakim, Marwan; Shehada, Nisrean; Broza, Yoav Y.; Billan, Salem; Abdah-Bortnyak, Roxolyana; Kuten, Abraham; Haick, Hossam

doi:10.1038/nnano.2009.235

Cited by 1,122 publications

(965 citation statements)

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“…In addition, Au and Ag nanostructures are relatively stable in ambient environments. They have, therefore, been intensively studied from the perspectives of both fundamental sciences [1][2][3] and potential applications in optics, [4][5][6] sensing, [7][8][9][10] imaging, [ 11 , 12 ] information processing, [ 13 ] photothermal therapeutics, [ 11 , 12 ] solar energy harvesting, [ 14 , 15 ] and photocatalysis. [ 16 , 17 ] Gold nanocrystals, especially Au nanorods, have been widely used as detection agents for analytical and biochemical applications as well as photothermal therapy, [ 11 , 12 ] owing to their chemical stability, synthetically tunable plasmon resonance bands within the visible and near-infrared spectral regions, and facile surface functionalization using thiol-containing molecules.…”

Section: Doi: 101002/adma201201896mentioning

confidence: 99%

Unraveling the Evolution and Nature of the Plasmons in (Au Core)–(Ag Shell) Nanorods

et al. 2012

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Evolution of the sizes and plasmonic properties of (Au core)−(Ag shell) nanorods is studied. Four plasmon bands are observed on the core−shell nanorods and their properties are investigated. The lowest‐energy one belongs to the longitudinal dipolar plasmon mode, the second‐lowest‐energy one belongs to the transverse dipolar plasmon mode, and the two highest‐energy ones are ascribed to octupolar plasmon modes.

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Section: Doi: 101002/adma201201896mentioning

confidence: 99%

Unraveling the Evolution and Nature of the Plasmons in (Au Core)–(Ag Shell) Nanorods

et al. 2012

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“…Among the various metallic nanomaterials, gold nanoparticles (GNPs) are widely applied in catalysis, 7 electronics, 8 and diagnostics. 9 Researchers have investigated variously shaped GNPs, especially anisotropic plate-shaped 10 and rod-shaped 11,12 GNPs. However, the mechanism of growth of these anisotropic GNPs is still not yet fully understood, so it remains challenging to synthesize complex GNPs of similar sizes that are homogenous in shape.…”

Section: Introductionmentioning

confidence: 99%

Kinetically Controlled Growth of Gold Nanoplates and Nanorods via a One-Step Seed-Mediated Method

Hong¹,

Acapulco²,

Jang³

et al. 2014

Bulletin of the Korean Chemical Society

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In this research, we further developed the one-step seed mediated method to synthesize gold nanoparticles (GNPs) and control their resulting shapes to obtain hexagonal, triangular, rod-shaped, and spherical gold nanostructures. Our method reveals that the reaction kinetics of formation of GNPs with different shapes can be controlled by the rate of addition of ascorbic acid, because this is the critical factor that dictates the energy barrier that needs to be overcome. This in turn affects the growth mechanism process, which involves the adsorption of growth species to gold nanoseeds. There were also observable trends in the dimensions of the GNPs according to different rates of addition of ascorbic acid. We performed further analyses to investigate and confirm the characteristics of the synthesized GNPs.

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“…The possibility to discriminate LC patients with e-nose devices has been recently demonstrated by several studies. [21][22][23] For instance, trained e-nose devices were able to identify the breath samples of patients with lung cancer and distinguish them from healthy controls, 24 as well as from patients having the three next most widespread primary cancers (colon, breast and prostate cancer). 21,24 In another study, the classification accuracy between LC patients and patients with head-and-neck cancer (highly correlated with tobacco smoking) achieved 100%, while the discrimination between LC patients and healthy controls was 96%.…”

Section: Introductionmentioning

confidence: 99%

“…[21][22][23] For instance, trained e-nose devices were able to identify the breath samples of patients with lung cancer and distinguish them from healthy controls, 24 as well as from patients having the three next most widespread primary cancers (colon, breast and prostate cancer). 21,24 In another study, the classification accuracy between LC patients and patients with head-and-neck cancer (highly correlated with tobacco smoking) achieved 100%, while the discrimination between LC patients and healthy controls was 96%. 25 On the other hand, a research study performed on a population of 30 volunteers (10 LC patients, 10 COPD and 10 healthy controls), provided 85% accuracy for the discrimination between LC and COPD patients, and 80-90% accuracy between LC patients and healthy controls.…”

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Smell, Lung Cancer, Electronic Nose and Trained Dogs

Bruno¹,

Haroution²,

Magda³

et al. 2014

JLPRR

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Lung cancer (LC) represents a problem of high magnitude for the medical systems due to its morbidity and mortality, also because of the huge human and economical efforts and costs that it catalyzes. Only in Europe, the average life-time cost of lung cancer patients ranges between €46,000 and €61,000 per patient.Secondary prevention, which consists in mass-screening of the high-risk population, could result of high benefit. For this aim to become a reality in the future, a potentially inexpensive and non-invasive approach for LC (pre)diagnosing is emerging. Such possibility relies on the detection of volatile biomarkers emitted from cell membranes. Tumor growth is accompanied by gene changes that may lead to oxidative stress, and the per oxidation of the cell membrane species causes volatile biomarkers to be emitted. Some of these biomarkers appear in distinctively different mixture compositions, depending on whether a cell is healthy or cancerous. These volatile biomarkers can be detected, among others, through the analysis of the exhaled breath, because the cancer-related changes in the blood chemistry are reflected in measurable changes to the breath through exchange via the lung. Importantly, these volatiles or their metabolic products are transmitted to the alveolar exhaled breath through exchange via the lung even at the very onset of the disease.There are several methods that can be applied to analyses the exhaled breath for the identification of a specific pattern of volatile biomarkers related with the target medical condition. The feasibility of three strategies, and the possible synergic effect of their concomitant application as a powerful pre-estimation tool for mass-screening of LC high-risk population:i. Spectrographic techniques such as Gas-Chromatography coupled to MassSpectrometry (GC-MS), which relies on reference libraries of analyses mass spectra to structurally identify and track the analyses in gaseous samples.ii. Electronic-nose (e-nose), which consists in a matrix of chemical gas sensors specifically trained for the target application by means of a pattern recognition algorithm. chemistry equipment such as Gas-Chromatography coupled to Mass-Spectrometry (GC-MS), which relies on reference libraries of analytes mass spectra to structurally identify and track the VOCs in gaseous samples. 12 The first study regarding the identification in the exhaled air of LC patients of several VOCs associated with this disease using the GC-MS was published in the '80s. 13 Since then, >100 different VOCs were identified in the breath of patients with lung cancer. Keywords14 These comprise seven families of compounds, such as hydrocarbons (alkanes, branched-chain alkanes and branched-chain alkenes), primary and secondary alcohols, aldehydes and branched aldehydes, ketones, esters, nitriles and aromatic compounds. 15Patient's classification is then realized through the statistical analysis of the selected volatile biomarkers in the breath. This way, for example, it was possible to discriminate between...

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Diagnosing lung cancer in exhaled breath using gold nanoparticles

Cited by 1,122 publications

References 26 publications

Unraveling the Evolution and Nature of the Plasmons in (Au Core)–(Ag Shell) Nanorods

Unraveling the Evolution and Nature of the Plasmons in (Au Core)–(Ag Shell) Nanorods

Kinetically Controlled Growth of Gold Nanoplates and Nanorods via a One-Step Seed-Mediated Method

Smell, Lung Cancer, Electronic Nose and Trained Dogs

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