Diagnosing rheumatic heart disease: where are we now and what are the challenges?

Loizaga, Sarah R de; Beaton, Andrea; Nascimento, Bruno Ramos; Macedo, Frederico V.B.; Spolaor, Breno Camargos Mucelli; Pádua, Lucas Bretas de; Ribeiro, Thomas Felipe Silva; Oliveira, Graziella Lage; Oliveira, Lucas Rocha; Almeida, Luís Felipe R. de; Moura, Thomás Diniz; Barros, Talisson Taglialegna de; Sable, Craig; Nunes, Maria Carmo Pereira

doi:10.1080/14779072.2021.1970531

Expert Review of Cardiovascular Therapy

2021

DOI: 10.1080/14779072.2021.1970531

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Diagnosing rheumatic heart disease: where are we now and what are the challenges?

Sarah R de Loizaga

Andrea Beaton

Bruno Ramos Nascimento

et al.

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Cited by 3 publications

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Echocardiography Assessment of Rheumatic Heart Disease: Implications for Percutaneous Balloon Mitral Valvuloplasty

Mohamed Ali,

Packer,

Omdal

et al. 2023

Current Problems in Cardiology

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Echocardiography Assessment of Rheumatic Heart Disease: Implications for Percutaneous Balloon Mitral Valvuloplasty

Mohamed Ali,

Packer,

Omdal

et al. 2023

Current Problems in Cardiology

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Inflammatory Response Genes’ Polymorphism Associated with Risk of Rheumatic Heart Disease

Sinitskaya,

Khutornaya,

Hryachkova

et al. 2024

JPM

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Rheumatic heart disease (RHD) caused by group A streptococcus infection is one of the most important reasons of cardiovascular morbidity and mortality in low- and middle-income countries. Aberrant host immune response modulated by polymorphisms in inflammatory response genes plays an important role in RHD pathogenesis. This study aimed to determine risk-associated polymorphic variants in inflammatory response genes in Caucasian RHD patients. A total of 251 Caucasian RHD patients and 300 healthy donors were recruited for this study, and 27 polymorphic sites in 12 genes (TLR1, TLR2, TLR4, TLR6, IL1B, IL6R, IL6, IL10, IL12RB1, IL12B, TNF and CRP) were analyzed using allele-specific PCR. It was demonstrated that the polymorphic variants rs1800871 and rs1800872 in the IL10 gene, rs 1130864, rs3093077 and rs1205 in the CRP gene, rs375947 in the IL12RB1 gene, rs 5743551 and rs5743611 in the TLR1 gene, and rs3775073 in the TLR6 gene can modify RHD risk in a gender- and age-dependent manner. The obtained results can be used to determine the personalized risk of RHD in healthy donors during medical examination or screening, as well as to develop appropriate early prevention strategies targeting RHD in the risk groups.

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Prediction of Left Ventricle Function from Pre-Operative Left Ventricle End-Systolic Dimension in Mitral Valve Replacement

Saleem¹,

Iqbal²,

Saleem³

2022

PJHS

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Rheumatic heart disease is an endemic in developing countries. The most common valve affected is the mitral valve for which mitral valve replacement is done. Left Ventricle Function (LVEF) is used to measure the prognosis of patients after MVR. Patients with a good LVEF perform better with less morbidity and mortality in comparison to patients with low post-operative EF. Therefore, prediction of post-operative EF is mandatory in patient’s selection and post-operative management. Objective: To determine the effect of pre-operative left ventricular end-systolic dimension in predicting postoperative LV function in mitral valve replacement. Methods: A total of 100 patients with mitral valve replacement were selected for the research. The study was conducted at the cardiac surgery department of National Institute of Cardiovascular Diseases, Karachi from April 2022 to October 2022. Results: The mean age of patients was 37 ± 10 years, LVESD: 34.7 ± 8.4mm, LVEDD: 51.1 ± 9.1mm, PASP: 44 ± 11mmHg, and EF of 55 ± 9%. Patients having Left ventricular end-systolic dimension (LVESD)> 38 mm had a significant post-operative left ventricular dysfunction after mitral valve replacement than patients having a pre-operative LVESD < 38mm (p= 0.003). Moreover, patients having a pre-operative LV dysfunction (EF <55%) were more prone to post-operative LV dysfunction(p=0.02). However, pre-operative LVESD is a more sensitive predictor of post-operative LV dysfunction than pre-operative LVEF (0.003<0.02). Conclusion: Left Ventricular End-Systolic Dimension (LVESD) is a more sensitive parameter as compared to pre-operative LV ejection fraction (LVEF) in predicting post-operative LV ejection fraction (LVEF) after mitral valve replacement (MVR).

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Diagnosing rheumatic heart disease: where are we now and what are the challenges?

Cited by 3 publications

References 77 publications

Echocardiography Assessment of Rheumatic Heart Disease: Implications for Percutaneous Balloon Mitral Valvuloplasty

Echocardiography Assessment of Rheumatic Heart Disease: Implications for Percutaneous Balloon Mitral Valvuloplasty

Inflammatory Response Genes’ Polymorphism Associated with Risk of Rheumatic Heart Disease

Prediction of Left Ventricle Function from Pre-Operative Left Ventricle End-Systolic Dimension in Mitral Valve Replacement

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