Diagnosis and Classification of Acute Leukaemia

Bain, Barbara J.

doi:10.1002/9780470987056.ch29

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…The secondary panel of markers recommended by the British committee [29] for the myeloid lineage are CD33, CD41, CD42, CD61 and anti glycophorin A. The consensus group recommends CD15, CD16, CD41, CD42b, CD61, CD64, CD117, anti cyMPO and, anti glycophrinA.…”

Section: Flowcytometry In Amlmentioning

confidence: 99%

Correlation of morphologic and cytochemical diagnosis with flowcytometric analysis in acute leukemia

et al. 2013

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Section: Flowcytometry In Amlmentioning

confidence: 99%

Correlation of morphologic and cytochemical diagnosis with flowcytometric analysis in acute leukemia

et al. 2013

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“…Our patient has Downs syndrome, SCD and AML-M2 by morphology using the French-American-British (FAB) classification. AML-M2 is associated with the translocation t (8,21) [24]. The presence of an extra chromosome 21 probably increases the chance of having this translocation.…”

Section: Discussionmentioning

confidence: 99%

Acute Myeloblastic Leukaemia in a Patient with Downs Syndrome and Sickle Cell Anaemia: A Case Report

Pughikumo¹

2013

Pediat Therapeut

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“…The latter is characterised by blasts which co-express myeloid and lymphoid or concurrent B and T lineage antigens. A scoring system (Table 2) proposed by the European Group for the Immunologic Classification of Leukaemia (EGIL) is used for this [3,4]. Detected antigens are given a score of 2, 1, or 0.5 depending on the specificity of that particular antigen for myeloid, T-lymphoid, or B-lymphoid lineages [5].…”

Section: Ceylon Medical Journalmentioning

confidence: 99%

Acute leukaemia of ambiguous lineage – a diagnostic dilemma

et al. 2009

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Acute leukaemia of ambiguous lineage (ALAL) is a rare form of leukaemia in which morphologic, cytochemical and immuno-phenotypic features of the proliferating blasts lack sufficient evidence to classify them as myeloid or lymphoid in origin or have characteristics of both myeloid and lymphoid cells. We report a 22-year old man presenting with clinical features of an acute lymphoblastic leukaemia but blasts in his blood and bone marrow with morphological features of myeloblasts. His immunophenotyping by flowcytometry showed antigens specific for both myeloid and B-lymphoid lineages. We highlight the importance of correlating clinical features with cellular morphology when diagnosing acute leukaemias, especially when facilities for flowcytometry are not routinely available.

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Diagnosis and Classification of Acute Leukaemia

Cited by 4 publications

References 9 publications

Correlation of morphologic and cytochemical diagnosis with flowcytometric analysis in acute leukemia

Correlation of morphologic and cytochemical diagnosis with flowcytometric analysis in acute leukemia

Acute Myeloblastic Leukaemia in a Patient with Downs Syndrome and Sickle Cell Anaemia: A Case Report

Acute leukaemia of ambiguous lineage – a diagnostic dilemma

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