Diagnosis and consequences of gastropharyngeal reflux

Smit, Conrad F.; Mathus-Vliegen, Lisbeth; Devriese, P. P.; Schouwenburg, Paul F.; Kupperman, D.S.

doi:10.1046/j.1365-2273.2000.00418.x

Cited by 30 publications

(22 citation statements)

References 113 publications

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“…Acid exposure in the hypopharynx can easily be missed because of the relatively large space within the hypopharynx [15] . On the contrary, placement of the proximal probe in or below the upper esophageal sphincter allows for more permanent contact with the mucosa during the 24-h period and this results in fewer artifacts [15,16] . We used a dual-site pH probe with electrodes placed at the tip and 15 cm proximal to the tip, and we could not choose the exact location of the proximal probe.…”

Section: Discussionmentioning

confidence: 99%

“…Yet in most cases (75.4%, 346/459), the proximal probe was located in the UES. So, for the diagnosis of GPRD, we used the criteria proposed by Smit et al [15,16] . Why is IEM not associated with GPRD as well as GERD?…”

Section: Discussionmentioning

confidence: 99%

“…For the number of reflux episodes, more than 4 reflux episodes were considered pathological [15,16] .…”

Section: Ambulatory 24-h Dual-probe Ph Monitoringmentioning

confidence: 99%

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Is ineffective esophageal motility associated with gastropharyngeal reflux disease?

Kim

Kim²,

Kim³

et al. 2008

WJG

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AIM:To evaluate the association between ineffective esophageal motility (IEM) and gastropharyngeal reflux disease (GPRD) in patients who underwent ambulatory 24-h dual-probe pH monitoring for the evaluation of supraesophageal symptoms. METHODS: A total of 632 patients who underwent endoscopy, esophageal manometry and ambulatory 24-h dual-pH monitoring due to supraesophageal symptoms (e.g. globus, hoarseness, or cough) were enrolled. Of them, we selected the patients who had normal esophageal motility and IEM. The endoscopy and ambulatory pH monitoring findings were compared between the two groups. RESULTS: A total of 264 patients with normal esophageal motility and 195 patients with the diagnosis of IEM were included in this study. There was no difference in the frequency of reflux esophagitis and hiatal hernia between the two groups. All the variables showing gastroesophageal reflux and gastropharyngeal reflux were not different between the two groups.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Is ineffective esophageal motility associated with gastropharyngeal reflux disease?

Kim

Kim²,

Kim³

et al. 2008

WJG

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“…Für Daten, die am unteren Ösophagussphinkter gewonnen wurden,stehen hier mit dem DeMeester-Score oder besser noch mit der kumulierten Expositionszeit <pH 4 gut validierte und anerkannte Normalwerte zur Verfügung [19]. Ungleich schwieriger erscheint die Definition von Normalwerten für den öso-phagolaryngealen Übergang.…”

Section: > Als Leitsymptom Des Refluxes Am Distalen öSophagussphinkteunclassified

“…Zusammenfassend bleibt festzustellen, dass eine Assoziation zwischen Globus pharyngis und ösophagolaryngealem Reflux zu bestehen scheint.Ein kausaler Zusammenhang ist hingegen bislang nicht ausreichend belegt. Es existiert sogar die Hypothese, dass der Globus für sich geeignet ist,den oberen Ösophagussphink-ter zu relaxieren und somit Reflux erst zu verursachen [19].…”

Section: Globus Pharyngisunclassified

Laryngopharyngealer Reflux

Sittel

2003

HNO

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Der Nachweis eines Refluxgeschehens ist im proximalen Ösophagus schwieriger zu führen als am distalen Sphinkter, da verlässliche klinische Symptome fehlen. Andererseits stehen zahlreiche HNO-ärztlicher Krankheitsbilder im Verdacht, refluxassoziiert zu sein. Eine rein probative Therapie mit Protonenpumpenhemmern ist daher kritisch zu betrachten.Wünschenswert wäre vielmehr eine objektive, wenig belastende Diagnostik mit vertretbarem Aufwand. Neue Möglichkeiten der ph-Metrie können dabei hilfreich sein.Das Adenokarzinom des Ösophagus,frü-her ein vergleichsweise seltener Tumor, hat in den letzten 3 Dekaden in den westlichen Industrieländern dramatisch an Häufigkeit zugenommen. Heute besteht kein Zweifel mehr daran, das es sich bei dieser Erkrankung um eine Folge der Refluxösophagitis und der dadurch bedingten metaplastischen Umwandlung der distalen Ösophagusschleimhaut (BarrettÖsophagus) handelt.

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Reflux and aerodigestive tract diseases

Coca‐Pelaz

Rodrigo

Paccagnella

et al. 2012

Eur Arch Otorhinolaryngol

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Gastroesophageal reflux disease can present with a wide variety of extraesophageal symptoms. In particular, the type of disease characterized predominately by laryngopharyngeal reflux may be difficult to diagnose because of the absence of regurgitation or heartburn. The available battery of diagnostic tools is often insufficient to confirm a diagnosis of reflux, so the diagnosis is often made by elimination. In many cases, treatment with proton pump inhibitors will relieve symptoms and respiratory complications, despite the persistence of non-acidic reflux. Such treatment is often employed to "confirm" the diagnosis, as measured by patient response. Many diseases have been related to this condition in the literature. The authors review knowledge about these manifestations and their relationship with refluxed gastric content. Physiopathology, symptoms and treatment are reviewed in order to clarify our understanding of laryngopharyngeal reflux diseases and related manifestations.

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Diagnosis and consequences of gastropharyngeal reflux

Cited by 30 publications

References 113 publications

Is ineffective esophageal motility associated with gastropharyngeal reflux disease?

Is ineffective esophageal motility associated with gastropharyngeal reflux disease?

Laryngopharyngealer Reflux

Reflux and aerodigestive tract diseases

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