BackgroundCorticosteroids are a potential risk factor for mortality in patients with perforated diverticular disease, due to blinding of disease severity, hampered wound healing or adrenal insufficiency. We examined mortality in corticosteroid users and non-users among patients with perforated diverticular disease.MethodsA cohort study based on medical databases including all patients â„18â
years in Denmark (source population 5â
289â
261 inhabitants) admitted to a hospital with incident perforated diverticular disease between 2005 and 2013. 7-day, 1-month, 3-month and 1-year mortality risks in corticosteroid users and non-users were calculated using the KaplanâMeier method, and compared with Cox proportional hazard regression adjusted for age, sex and comorbidities.ResultsThe study included 4640 patients with perforated diverticular disease. Of these, 3743 (80.7%) had not used corticosteroids in the year before admission and 725 (15.6%) had been exposed to systemic corticosteroid treatment. The remaining 172 patients had been exposed to either inhaled or intestinal acting corticosteroid therapy. Mortality risk in non-users was 4.4% after 7â
days and 15.6% after 1â
year. This risk was doubled for corticosteroid users who filled their last prescription during the 90â
days before admission, with mortality risks ranging from 14.2% after 7â
days to 47.6% after 1â
year. 1-year mortality risk was even higher for corticosteroid users with a first filled prescription â€90â
days before admission: 52.5%.ConclusionsCorticosteroid use was associated with clearly increased mortality risk after perforated diverticular disease. Thus, use of corticosteroids should be regarded as an important clinical prognostic factor for mortality in patients with this condition.