Diagnosis and management of an unilateral giant fibroadenoma of the breast in pregnancy

Heilmann, Thorsten; Leuschner, Ivo; Hilpert, Felix; Kümper, C.; Strauß, Alexander; Mundhenke, Christoph; Jonat, W.; Bauer, M.

doi:10.1007/s00404-011-1923-9

Cited by 11 publications

(14 citation statements)

References 16 publications

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“…Fibroadenomas are benign neoplasms with epithelial (glandular) and stromal (fibrous) components, which predominantly occur in young women (3, 4). In giant fibroadenomas, a prominent glandular epithelium and an increased stromal cellularity are described (6).…”

Section: Discussionmentioning

confidence: 99%

“…It is important to note that phyllodes tumors (benign and malignant) frequently cause lymphadenopathy due to reactive changes and this should not be considered a sign of malignancy in these patients. Ultrasonography, mammography, magnetic resonance imaging or fine needle aspirations have not been helpful in definitely differentiating fibroadenoma from phyllodes tumor (4). While the phyllodes tumor should be surgically removed with safety margins, giant fibroadenomas are well encapsulated and should be enucleated.…”

Section: Discussionmentioning

confidence: 99%

“…Giant fibroadenomas can occur as unilateral macromastia without definable borders or texture differences on palpation. The incidence of primary breast cancer in women less than 20 years old is approximately 0.1%; there are reports of in situ ductal carcinoma and neoplasm in a fibroadenoma (4). These benign tumors most commonly affect women with African or Asian origins (4).…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of primary breast cancer in women less than 20 years old is approximately 0.1%; there are reports of in situ ductal carcinoma and neoplasm in a fibroadenoma (4). These benign tumors most commonly affect women with African or Asian origins (4). The exact etiology of giant fibroadenomas is unknown, but it is probably an abnormal response to estrogen, as evidenced by their increased frequency during puberty and responsiveness to pregnancy, oral contraceptives, and cyclic hormones (3, 5).…”

Section: Introductionmentioning

confidence: 99%

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Giant Fibroadenoma Growing Rapidly During Pregnancy

Karagülle¹,

Türk²,

Erinanç³

et al. 2014

Iran Red Crescent Med J

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Introduction:Giant fibroadenoma is a rare disease with unknown etiology. During pregnancy, fibroadenomas increase in size and may show lactational histologic changes. High concentrations of estrogen, progesterone, and prolactin promote the ductal growth and formation of tubuloalveolar structures. This may be a reason for the significant enlargement in this period.Case Presentation:We presented a case of giant fibroadenoma, first detected at the onset of pregnancy, which grew rapidly and was excised surgically two months after the birth. There was no marked deformity in the breast nor a need to reconstruct it, despite the giant mass was excised and the mother was lactating.Discussion:We presented a rare case of giant fibroadenoma in a lactating woman. A progressively growing mass in breast can lead to structural damages. The current management approach for giant fibroadenomas is still surgical excision.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Giant Fibroadenoma Growing Rapidly During Pregnancy

Karagülle¹,

Türk²,

Erinanç³

et al. 2014

Iran Red Crescent Med J

View full text Add to dashboard Cite

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“…About 2-4% of the fibroadenomas more than 5 cm in size or 500 gm in weight and are called giant fibroadenomas [1]. The axillary ectopic breast tissue is common in women as 95% of women are having it [2].…”

Section: Introductionmentioning

confidence: 99%

Giant Axillary Fibroadenoma: A Rare Case Report

Arora¹

2017

MOJCR

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Positive association between progestins and the evolution of multiple fibroadenomas in 72 women

Grouthier

Chakhtoura

Tejedor

et al. 2020

Endocrine Connections

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Objective Multiple fibroadenomas (MFA) of the breast is a rare benign disease, thus its natural history is poorly understood. The aim of our study was to describe the radiological evolution of MFA and to evaluate the influence of different factors on this evolution. Methods This was a longitudinal cohort study. All patients included had two clinical and radiological assessments (breast ultrasound (US) and/or MRI) at least 5 years apart. Results Seventy-two women were followed for 7.6 ± 2.1 years. The radiological evolution showed a decrease or stability in the number of fibroadenomas (FA) in 26/44 cases on the MRI and in 38/64 cases on the US. There was a decrease of size in 35/44 cases on the MRI and in 53/64 cases on the US. An increase in the number of FAs was found in 18/44 cases in the MRI and 26/64 cases in the US with, for the majority, a decrease of size (19/26 by MRI and 16/18 by MRI). Older age at the first FA (P < 0.0001) and at the diagnosis of MFA (P < 0.0001), pregnancy (P = 0.003) and progestin use (P < 0.001), particularly lynestrenol (P < 0.0001), had a beneficial effect on the evolution of MFA. Conclusion This is the first longitudinal study describing women with MFA. The radiological evolution of MFA seamed favorable and similar to that expected for a single FA. We identified factors influencing the evolution of the disease, including progestin treatments such as lynestrenol, which could have a beneficial effect. Our cohort should be followed further in order to expand our knowledge of MFA, especially concerning the risk of breast cancer.

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Diagnosis and management of an unilateral giant fibroadenoma of the breast in pregnancy

Cited by 11 publications

References 16 publications

Giant Fibroadenoma Growing Rapidly During Pregnancy

Giant Fibroadenoma Growing Rapidly During Pregnancy

Giant Axillary Fibroadenoma: A Rare Case Report

Positive association between progestins and the evolution of multiple fibroadenomas in 72 women

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