Diagnosis and management of ankylosing spondylitis

McVeigh, Claire; Cairns, Andrew

doi:10.1136/bmj.38954.689583.de

Cited by 105 publications

(70 citation statements)

References 28 publications

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“…AS is an inflammatory disease principally affecting the sacroiliac joints at the base of the spine and the spine itself, causing back pain, stiffness, and risk of spinal fracture in later stages of the disease [2][3][4]. There may be the development of new bone and joint fixation, termed ankylosis.…”

Section: Introductionmentioning

confidence: 99%

Modeling Health State Utility Values in Ankylosing Spondylitis: Comparisons of Direct and Indirect Methods

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Modeling Health State Utility Values in Ankylosing Spondylitis: Comparisons of Direct and Indirect Methods

et al. 2015

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“…Prevalence estimates of AS vary between 0.1 and 2% in diVerent populations [10]. Diagnosis of AS is deWnite when one of the radiological criteria is fulWlled (bilateral sacroiliitis grade two or higher; or unilateral sacroiliitis grade three or higher) with any clinical criterion (low back pain of at least 3 months duration with inXammatory characteristics (improved by exercise, not relieved by rest); limitation of lumbar spine motion in sagittal and frontal planes; or decreased chest expansion (relative to normal values for age and sex) [12][13][14]. However, radiological sacroiliitis may not develop for many years [2].…”

Section: Discussionmentioning

confidence: 99%

Screening and evaluating the mimic peptides as a useful serum biomarker of ankylosing spondylitis using a phage display technique

Wang

Chen

et al. 2010

Rheumatol Int

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To screen specific serum biomarker for ankylosing spondylitis (AS) using a phage random peptide library. A phage random peptide library of random peptide 12-mers was immunoscreened with purified immunoglobulin (Ig) G from sera of AS patients. Positive clones obtained after three rounds of biopanning were detected with ELISA and sequenced. Reaction of the screened positive clones with sera from AS patients, systemic lupus erythematosus (SLE) patients, rheumatoid arthritis (RA) patients, osteoarthritis (OA) patients and healthy controls was detected using phage ELISA. Correlation among erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and the absorbance value of the positive clone in phage ELISA was examined in AS patients. Seventeen out of twenty randomly selected phage clones exhibited specific reaction with purified sera IgG from AS patients, among them seven coming from the same clone whose inserted peptide sequence was LALPPLAPNHHH (named "AS1"). Phage ELISA results showed that the positive reaction rate of the AS1 clone was 92.0% with AS patients, significantly different (P < 0.01) from those with SLE patients (56.7%), RA patients (50.0%), OA patients (13.3%), and healthy controls (14.0%). Absorbance value of the AS1 clone in phage ELISA was significantly higher than those in the other groups (P < 0.05). In addition, the absorbance value of the AS1 clone showed no statistically significant correlation with ESR and CRP in AS patients, suggesting that AS1 detects AS patients through a unique mechanism other than inflammation. The short peptide AS1 obtained through screening of a phage random peptide library with purified serum IgG from AS patients can specifically react with the sera of AS patients, and thereby may be a candidate of AS-specific serum biomarkers.

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“…Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by pain and progressive stiffness, mainly affecting the spinal column and sacroiliac joints [4]. Although the sacroiliac joints and lumbar spines are most commonly affected, the entire spinal column may be involved with advanced disease [5].…”

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confidence: 99%

Psychological effects of calisthenic exercises on neuroinflammatory and rheumatic diseases

et al. 2015

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Diagnosis and management of ankylosing spondylitis

Cited by 105 publications

References 28 publications

Modeling Health State Utility Values in Ankylosing Spondylitis: Comparisons of Direct and Indirect Methods

Modeling Health State Utility Values in Ankylosing Spondylitis: Comparisons of Direct and Indirect Methods

Screening and evaluating the mimic peptides as a useful serum biomarker of ankylosing spondylitis using a phage display technique

Psychological effects of calisthenic exercises on neuroinflammatory and rheumatic diseases

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