Diagnosis and Management of Bipolar Disorder in Primary Care

Brenner, Carolyn J.; Shyn, Stanley I.

doi:10.1016/j.mcna.2014.06.004

Cited by 14 publications

(7 citation statements)

References 77 publications

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“…BD is associated with multiple medical and psychiatric comorbidities, such as cardiovascular disease, diabetes mellitus, obesity, and thyroid dysfunction. Furthermore, this medical condition is accompanied by significant functional impairment, deterioration of both the patients and the patients' families' quality of life, and higher rates of suicide [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Histone Deacetylase Inhibition on the Levels of Cerebral Cytokines in an Animal Model of Mania Induced by Dextroamphetamine

et al. 2017

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Studies have suggested the involvement of inflammatory processes in the physiopathology of bipolar disorder. Preclinical evidences have shown that histone deacetylase inhibitors may act as mood-stabilizing agents and protect the brain in models of mania and depression. The aim of the present study was to evaluate the effects of sodium butyrate (SB) and valproate (VPA) on behavioral changes, histone deacetylase activity, and the levels of cytokines in an animal model of mania induced by dextroamphetamine (d-AMPH). Wistar rats were first given d-AMPH or saline (Sal) for a period of 14 days, and then, between the 8th and 14th days, the rats were treated with SB, VPA, or Sal. The activity of histone deacetylase and the levels of cytokines (interleukin (IL) IL-4, IL-6, and IL-10 and tumor necrosis factor-alpha (TNF-α)) were evaluated in the frontal cortex and striatum of the rats. The administration of d-AMPH increased the activity of histone deacetylase in the frontal cortex. Administration of SB or VPA decreased the levels of histone deacetylase activity in the frontal cortex and striatum of rats. SB per se increased the levels of cytokines in both of the brain structures evaluated. AMPH increased the levels of cytokines in both of the brain structures evaluated, and VPA reversed this alteration. The effects of SB on d-AMPH-induced cytokine alterations were dependent on the brain structure and the cytokine evaluated. Despite VPA and SB having a similar mechanism of action, both being histone deacetylase inhibitors, they showed different effects on the levels of cytokines. The present study reinforces the need for more research into histone deacetylase inhibitors being used as a possible target for new medications in the treatment of bipolar disorder.

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Section: Introductionmentioning

confidence: 99%

The Effects of Histone Deacetylase Inhibition on the Levels of Cerebral Cytokines in an Animal Model of Mania Induced by Dextroamphetamine

et al. 2017

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“…2 BD involves men and women equally with a peak age onset typically between ages 18-20 years. 3 In Colombia, the lifetime prevalence of BD-I is 1.8%. 4 BD patients are more likely to have poor adherence, drug interactions, self-medication, drug-related side effects, and adverse reactions.…”

mentioning

confidence: 99%

Effectiveness of the Dader Method for Pharmaceutical Care on Patients with Bipolar I Disorder: Results from the EMDADER-TAB Study

Salazar-Ospina

Amariles

García

et al. 2017

JMCP

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This study received funding from the Universidad de Antioquia, Committee for Development Research and Sustainability Program, CODI, (2013-2014 and 2014-2015). Humax Pharmaceutical provided support for the initial development of the EMDADER-TAB trial without commercial interest in the outcomes derived from the trial. Salazar-Ospina reports grants from Credito Beca Francisco José de Caldas Scholarship for Doctoral Programs (528), which also contributed to the support of this study. González-Avendaño is an employee of Humax Pharmaceutical. The other authors have nothing to disclose. Study concept and design were contributed by Benjumea, Faus, and Rodriguez, along with Salazar-Ospina and Amariles. Salazar-Ospina took the lead in data collection, assisted by González-Avendaño, and data interpretation was performed by Salazar-Ospina, Hincapié-García, and González-Avendaño. The manuscript was written primarily by Salazar-Ospina, with assistance from Amariles and González-Avendaño, and revised by all the authors.

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“…In primary care settings, it is estimated that about 4% of patients currently have bipolar disorders 2 and up to 10% of patients will have been diagnosed with bipolar disorder at some point in their life. 3 These statistics speak to the need for primary care centers to have pathways in place to assist in assessing, diagnosing, and treating bipolar disorder. A collaborative effort among integrated care team members is essential for optimal long term management of bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

Bipolar disorder: Managing the peaks and valleys

Johnson

Fields

Bluett³

2020

Int J Psychiatry Med

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Bipolar disorder is a psychiatric illness that is relatively common among patients presenting for treatment in primary care clinics. Physicians in primary care often face difficult decisions about how and when to intervene when a patient is experiencing depressive, manic, or hypomanic episodes consistent with bipolar disorder. This article reviews the literature on how to assess and diagnose bipolar disorder in primary care, and how to choose from the array of treatment options that exist. The psychotherapy and pharmacotherapy evidence base provides guidance on how to help patients effectively manage this ailment. Collaboration among health and mental health practitioners is key in helping manage the “peaks and valleys” of bipolar disorder. Special considerations need to be made to routinely assess for impulsivity, suicidality, and patient progress throughout the course of treatment.

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Diagnosis and Management of Bipolar Disorder in Primary Care

Cited by 14 publications

References 77 publications

The Effects of Histone Deacetylase Inhibition on the Levels of Cerebral Cytokines in an Animal Model of Mania Induced by Dextroamphetamine

The Effects of Histone Deacetylase Inhibition on the Levels of Cerebral Cytokines in an Animal Model of Mania Induced by Dextroamphetamine

Effectiveness of the Dader Method for Pharmaceutical Care on Patients with Bipolar I Disorder: Results from the EMDADER-TAB Study

Bipolar disorder: Managing the peaks and valleys

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