Diagnosis and management of cow’s milk protein allergy in infants

Greef, Elisabeth De; Hauser, Bruno; Devreker, Thierry; Veereman-Wauters, G.; Vandenplas, Yvan

doi:10.1007/s12519-012-0332-x

Cited by 63 publications

(61 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Se requieren más estudios prospectivos en la región para desarrollar estrategias públicas de prevención en salud y diagnóstico temprano 7,21,33,37,42,48,50,[53][54][55][56][57][58][59] .…”

Section: Discussionunclassified

“…Las formas de presentación clínica digestiva más frecuentes en este grupo de pacientes fueron vómito/regurgitación y la diarrea sanguinolenta en el 70% de los lactantes, lo cual está de acuerdo con otros estudios en Latino-américa 14,15 y en el resto del mundo 5,7,29,42,46,47 . Solamente en el 50% de los pacientes hubo sospecha de APLV por parte del pediatra y en la mayoría de pacientes se usaron conductas nutricionales inapropiadas tales como: el uso de otras fórmulas a base de PLV, soya, sin lactosa e inclusive la suspensión de la lactancia materna.…”

Section: Discussionunclassified

“…Se excluyeron historias clínicas de lactantes que no tuvieron prueba de eliminación y provocación abierta o que hubieran consultado por otras causas: síndrome de malabsorción, enfermedades metabólicas, hepáticas, renales, etc. 1,[3][4][5][6][7][8]10,[16][17][18][19][20]22,23,25,[27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] .La Información de las historias clínicas, fue recolectada del sistema de información HIS-ISIS ® del HU-FSFB y MEDSYS V4.0 ® de la Asociación Médica de los Andes (AMA), en un cuestionario. Se realizó una prueba piloto en 10 pacientes.…”

Section: Pacientes Y Métodounclassified

“…El cuadro clí-nico aunque es variable requiere un alto índice de sospecha 6 . No hay estudios suficientes en Colombia que muestren el comportamiento clínico ni la historia natural de la APLV en lactantes [3][4][5][6][7][8] .…”

Section: Introductionunclassified

“…Ninguna de las pruebas diagnósticas disponibles en la rutina clínica prueba o excluye por completo la APLV 7,26 . Una buena historia clí-nica, incluyendo antecedentes familiares de atopia, antecedentes de madre fumadora 17 , hiperbilirrubinemia neonatal, aumento de la tripsina fecal 19 , ser de género masculino 25 y un examen clínico cuidadoso son la clave en el proceso de diagnóstico.…”

Section: Introductionunclassified

See 4 more Smart Citations

Síntomas digestivos y respuesta clínica en lactantes con alergia a la proteína de leche de vaca

Vera

Ramírez

2013

Rev. chil. pediatr.

View full text Add to dashboard Cite

Section: Discussionunclassified

Section: Pacientes Y Métodounclassified

Section: Introductionunclassified

See 3 more Smart Citations

Síntomas digestivos y respuesta clínica en lactantes con alergia a la proteína de leche de vaca

Vera

Ramírez

2013

Rev. chil. pediatr.

View full text Add to dashboard Cite

A free amino acid‐based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey

Sadelhoff

Hogenkamp

Wiertsema

et al. 2020

Immunity Inflam & Disease

View full text Add to dashboard Cite

Background: Amino acid-based formulas (AAFs) are used for the dietary management of cowʼs milk allergy (CMA). Whether AAFs have the potential to prevent the development and/or symptoms of CMA is not known.Objective: The present study evaluated the preventive effects of an amino acid (AA)-based diet on allergic sensitization and symptoms of CMA in mice and aimed to provide insight into the underlying mechanism. Methods: C3H/HeOuJ mice were sensitized with whey protein or with phosphate-buffered saline as sham-sensitized control. Starting 2 weeks before sensitization, mice were fed with either a protein-based diet or an AA-based diet with an AA composition based on that of the AAF Neocate, a commercially available AAF prescribed for the dietary management of CMA. Upon challenge, allergic symptoms, mast cell degranulation, whey-specific immunoglobulin levels, and FoxP3 + cell counts in jejunum sections were assessed.Results: Compared to mice fed with the protein-based diet, AA-fed mice had significantly lower acute allergic skin responses. Moreover, the AA-based diet prevented the whey-induced symptoms of anaphylaxis and drop in body temperature. Whereas the AA-based diet had no effect on the levels of serum IgE and mucosal mast cell protease-1 (mMCP-1), AA-fed mice had significantly lower serum IgG2a levels and tended to have lower IgG1 levels (P = .076). In addition, the AA-based diet prevented the whey-induced decrease in FoxP3 + cells. In sham-sensitized mice, no differences between the two diets were observed in any of the tested parameters. Conclusion: This study demonstrates that an AA-based diet can at least partially prevent allergic symptoms of CMA in mice. Differences in FoxP3 + cell counts and serum levels of IgG2a and IgG1 may suggest enhanced antiinflammatory and tolerizing capacities in AA-fed mice. This, combined with ---This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.How to cite this article: van Sadelhoff JHJ, Hogenkamp A, Wiertsema SP, et al. A free amino acid-based diet partially prevents symptoms of cowʼs milk allergy in mice after oral sensitization with whey. Immun Inflamm Dis. 2020;8:93-105.

show abstract

Formulation, pilot‐scale preparation, physicochemical characterization and digestibility of a lentil protein‐based model infant formula powder

et al. 2021

View full text Add to dashboard Cite

BACKGROUND: Infant formula is a human milk substitute for consumption during the first months of life. The protein component of such products is generally of dairy origin. Alternative sources of protein, such as those of plant origin, are of interest due to dairy allergies, intolerances, and ethical and environmental considerations. Lentils have high levels of protein (20-30%) with a good amino acid profile and functional properties. In this study, a model lentil protein-based formula (LF), in powder format, was produced and compared to two commercial plant-based infant formulae (i.e., soy; SF and rice; RF) in terms of physicochemical properties and digestibility.Results: The macronutrient composition was similar between all the samples; however, RF and SF had larger volume-weighted mean particle diameters (D[4,3] of 121-134 ∼m) than LF (31.9 ∼m), which was confirmed using scanning electron and confocal laser microscopy. The larger particle sizes of the commercial powders were attributed to their agglomeration during the drying process. Regarding functional properties, the LF showed higher D[4,3] values (17.8 ∼m) after 18 h reconstitution in water, compared with the SF and RF (5.82 and 4.55 ∼m, respectively), which could be partially attributed to hydrophobic protein-protein interactions. Regarding viscosity at 95 °C and physical stability, LF was more stable than RF. The digestibility analysis showed LF to have similar values (P < 0.05) to the standard SF.Conclusion: These results demonstrated that, from the nutritional and physicochemical perspectives, lentil proteins represent a good alternative to other sources of plant proteins (e.g., soy and rice) in infant nutritional products.

show abstract

Diagnosis and management of cow’s milk protein allergy in infants

Cited by 63 publications

References 44 publications

Síntomas digestivos y respuesta clínica en lactantes con alergia a la proteína de leche de vaca

Síntomas digestivos y respuesta clínica en lactantes con alergia a la proteína de leche de vaca

A free amino acid‐based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey

Formulation, pilot‐scale preparation, physicochemical characterization and digestibility of a lentil protein‐based model infant formula powder

Contact Info

Product

Resources

About