Diagnosis and Management of Leukemic and Lymphomatous           Meningitis

Murthy, Hemant S.; Anasetti, Claudio; Ayala, Ernesto

doi:10.1177/107327481702400105

Cited by 8 publications

(2 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The meningeal involvement of leukemia/lymphoma is a major complication that is difficult to treat [ 39 ]. Intrathecal and systemic chemotherapies, which are the main therapeutic approaches, have limited efficacy and repetitive chemotherapy has severe side effects, including pancytopenia.…”

Section: Discussionmentioning

confidence: 99%

Folic Acid-Appended Hydroxypropyl-β-Cyclodextrin Exhibits Potent Antitumor Activity in Chronic Myeloid Leukemia Cells via Autophagic Cell Death

Hoshiko

Kubota

Onodera

et al. 2021

Cancers

View full text Add to dashboard Cite

2-Hydroxypropyl-β-cyclodextrin (HP-β-CyD) is widely used as an enabling excipient in pharmaceutical formulations. We previously demonstrated that HP-β-CyD disrupted cholesterol homeostasis, and inhibited the proliferation of leukemia cells by inducing apoptosis and cell-cycle arrest. Recently developed drug delivery systems using folic acid (FA) and folic acid receptors (FR) are currently being used in cancer treatment. To confer tumor cell-selectivity to HP-β-CyD, we synthesized folate-appended HP-β-CyD (FA-HP-β-CyD) and evaluated the potential of FA-HP-β-CyD as an anticancer agent using chronic myeloid leukemia (CML) cells in vitro and in vivo. FA-HP-β-CyD inhibited the growth of FR-expressing cells but not that of FR-negative cells. FA-HP-β-CyD had stronger anti-leukemia and cell-binding activities than HP-β-CyD in CML cells. Unlike HP-β-CyD, FA-HP-β-CyD entered CML cells through endocytosis and induced both apoptosis and autophagy via mitophagy. FA-HP-β-CyD increased the inhibitory effects of the ABL tyrosine kinase inhibitors imatinib mesylate and ponatinib, which are commonly used in CML. In vivo experiments in a BCR-ABL leukemia mouse model showed that FA-HP-β-CyD was more effective than HP-β-CyD at a ten-fold lower dose. These results indicate that FA-HP-β-CyD may be a novel tumor-targeting agent for the treatment of leukemia.

show abstract

Section: Discussionmentioning

confidence: 99%

Folic Acid-Appended Hydroxypropyl-β-Cyclodextrin Exhibits Potent Antitumor Activity in Chronic Myeloid Leukemia Cells via Autophagic Cell Death

Hoshiko

Kubota

Onodera

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…Leukemic and lymphomatous meningitis tend to have a higher frequency of cranial nerve involvement. 4 In a series, 979 patients with simultaneous or serial involvement of 2 or more different cranial nerves were evaluated; almost one-third of patients had a tumor as the reason for multiple cranial neuropathies. Lymphomas and leukemias were diagnosed in 10% and 3% of cases, respectively.…”

Section: Sectionmentioning

confidence: 99%

Clinical Reasoning: A patient with multiple cranial nerve palsies and areflexic paraparesis

et al. 2018

View full text Add to dashboard Cite

A 62-year-old hypertensive man presented with 1.5-month history of bilateral facial nerve palsy evolving over 5 days, followed by double vision and restriction of eye movements for 1 month. He had progressive deterioration of vision of 20 days duration. His vital measures, except blood pressure (174/104 mm Hg), were normal. The patient was conscious, oriented, and obeyed commands and instructions. His vision was limited to appreciation of hand movements. Ophthalmoscopy revealed bilateral disk swelling with grade II hypertensive retinopathy. Pupils were dilated with a sluggish reaction to light. Cranial nerve examination further revealed bilateral third, fourth, sixth, and seventh cranial nerve palsies. Trigeminal nerve (V1-V3) sensations were intact. Hearing was normal. There was no tongue or palate weakness/ asymmetry. Tongue bulk was normal. Sternocleidomastoid and trapezius were normal. Power in the upper limbs was normal. In the lower limbs, power in all groups of muscles was grade 3/5 (Medical Research Council grade). There was generalized areflexia. Planters were flexor. Sensory examination was normal. There was nuchal rigidity with a positive Kerning sign. Other systemic and general examinations were unremarkable. Question for consideration: 1. What is the likely anatomical localization? GO TO SECTION 2

show abstract

Cerebrospinal Fluid

Torre

2019

Practical Cytopathology

View full text Add to dashboard Cite

Diagnosis and Management of Leukemic and Lymphomatous Meningitis

Cited by 8 publications

References 71 publications

Folic Acid-Appended Hydroxypropyl-β-Cyclodextrin Exhibits Potent Antitumor Activity in Chronic Myeloid Leukemia Cells via Autophagic Cell Death

Folic Acid-Appended Hydroxypropyl-β-Cyclodextrin Exhibits Potent Antitumor Activity in Chronic Myeloid Leukemia Cells via Autophagic Cell Death

Clinical Reasoning: A patient with multiple cranial nerve palsies and areflexic paraparesis

Cerebrospinal Fluid

Contact Info

Product

Resources

About