Diagnosis and Management of Sebaceous Carcinoma: An Australian Experience

Abstract

Sebaceous carcinoma is a rare tumour. Extraorbital SC is an aggressive and invasive malignancy. Excision margins may need to be wider than previously thought. Exposure to ultraviolet radiation (sunlight) may play a role in the aetiology. Wide excision and selective use of radiotherapy remain the treatment of choice.

Interobserver variability in the diagnosis of circumscribed sebaceous neoplasms of the skin

“…[6][7][8] Treatment involves at least a wide excision, in some cases with adjuvant radiotherapy. 9 Thus, overdiagnosis of this condition places the patient at risk of significant over-treatment, while under-diagnosis may be associated with adverse outcomes. This study has confirmed our anecdotal experience that there is significant interobserver variability in the diagnosis of cutaneous CSL.…”

Management Considerations in Extraocular Sebaceous Carcinoma

“…More recently, external beam radiation therapy (XRT) has been used successfully as adjuvant therapy after surgical excision in extraocular SC with lymph node involvement, extensive local invasion, or for recurrent disease. 19,35,36,[47][48][49][50][51][52][53] Of note, the majority of reported cases lack crucial information, including margin status after excision and location of radiation site. See Table 1 for a summary of 15 reported extraocular SC cases using XRT.…”

Multifocal Metastasizing Extra-Ocular Facial Sebaceous Carcinoma as Diagnostic Challenge: Case Report and Systematic Review

“…Resection with wide safety margins and selective use of radiotherapy remains the treatment of choice [34]. Sentinel-lymphnode biopsy is an established diagnostic method [12].…”