Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp ongenital left ventricular aneurysm (LVA) and diverticulum (LVD) are rare malformations and approximately 500 cases have been published in the literature since the first description in 1816. 1 A recent study found a prevalence of 0.76% in adult patients undergoing coronary angiography. 2 Although most investigators distinguish between LVA and LVD, the cause, histopathology, and clinical implications remain controversial. 3-7 The advent of echocardiography and magnetic resonance imaging has led to earlier diagnosis, including prenatal detection. 8-10 The published research on these anomalies consists, beside 1 large single center study, 2 of case reports and small case series, mostly on infants and young children with large aneurysms and poor clinical outcome. 10-16 High morbidity and mortality rates due to heart failure, aneurysm rupture, thromboembolism, and sudden death of unclear cause have been reported. 3,4 More recent published data demonstrated a more favorable course with no cardiac mortality in adults with congenital LVA and LVD. 2,8 A significant proportion of the published literature report arrhythmias in patients with these anomalies. 2,3,17-25 Recently, our own group was able to demonstrate that patients with congenital LVA/ LVD had a high incidence of distinctly abnormal electrocardiograms (ECGs) compared to an age-and gender-matched control group. 26 The purpose of the present study was to evaluate the prognosis and risk factors of patients with a diagnosis of isolated congenital LVA or LVD, having ECG abnormalities.
Methods
DefinitionThe diagnosis of congenital LVA or LVD was established after angiographic exclusion of coronary artery disease. Clinical and ECG local or systemic inflammation, traumatic causes and car- Background: Congenital left ventricular aneurysm (LVA) and diverticulum (LVD) are rare cardiac anomalies frequently associated with electrocardiogram (ECG) abnormalities. The aim of this study was to evaluate the long-term prognosis in such patients.