Diagnosis and outcomes of pregnant women with Zika virus infection in two municipalities of Risaralda, Colombia: Second report of the ZIKERNCOL study

Rodríguez‐Morales, Alfonso J.; Cardona-Ospina, Jaime A.; Ramírez-Jaramillo, Valeria; Gaviria, Javier A.; González-Moreno, Gloria María; Castrillón-Spitia, Juan Daniel; López-Villegas, Alejandra; Morales-Jiménez, Estefania; Ramírez-Zapata, Valentina; Rueda-Merchán, German Eduardo; Trujillo, Adriana M.; Tabares-Villa, Fredy A.; Henao-SanMartin, Valentina; Murillo-García, David R.; Herrera-Soto, Johana Andrea; Buitrago-Cañas, Marta Liliana; Collins, Matthew H.; Sepúlveda-Arias, Juan Carlos; Londoño, José J.; Bedoya-Rendón, Hector D.; Cárdenas-Pérez, Javier de Jesús; Olaya, Sandra; Lagos-Grisales, Guillermo J.

doi:10.1016/j.tmaid.2018.06.006

Cited by 30 publications

(20 citation statements)

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“…3 It has been estimated that GBS arises in approximately 2 per 10 000 ZIKV infections, 1 4 and the absolute risk of adverse birth outcomes (ie, miscarriage, stillbirth, premature birth and CZS) has been reported to range between 7% and 46% in pregnancies with quantitative real-time PCR (qRT-PCR)-confirmed ZIKV infection. [5][6][7][8] Although the clinical presentation of ZIKV monoinfections has been well characterised, one factor that may influence the clinical spectrum of ZIKV disease is coinfection. Given the high incidence of infectious diseases in the subtropical and tropical areas where ZIKV is prevalent, a proportion of all ZIKV infections occur concurrently with infections by one or multiple pathogens.…”

Section: Introductionmentioning

confidence: 99%

The frequency and clinical presentation of Zika virus coinfections: a systematic review

et al. 2020

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BackgroundThere is limited knowledge on the influence of concurrent coinfections on the clinical presentation of Zika virus (ZIKV) disease.MethodsTo better understand the types, frequencies and clinical manifestations of ZIKV coinfections, we did a systematic review of four databases (PubMed, Embase, Web of Science, LILACS) without restrictions for studies on ZIKV coinfections confirmed by nucleic acid (quantitative real-time-PCR) testing of ZIKV and coinfecting pathogens. The review aimed to identify cohort, cross-sectional, case series and case report studies that described frequencies and/or clinical signs and symptoms of ZIKV coinfections. Conference abstracts, reviews, commentaries and studies with imprecise pathogen diagnoses and/or no clinical evaluations were excluded.ResultsThe search identified 34 articles from 10 countries, comprising 2 cohort, 10 cross-sectional, 8 case series and 14 case report studies. Coinfections were most frequently reported to have occurred with other arthropod-borne viruses (arboviruses); out of the 213 coinfections described, ZIKV infections co-occurred with chikungunya in 115 cases, with dengue in 68 cases and with both viruses in 19 cases. Other coinfecting agents included human immunodeficiency, Epstein-Barr, human herpes and Mayaro viruses, Leptospira spp, Toxoplasma gondii and Schistosoma mansoni. ZIKV-coinfected cases primarily presented with mild clinical features, typical of ZIKV monoinfection; however, 9% of cases in cohort and cross-sectional studies were reported to experience complications.ConclusionBased on the evidence collated in this review, coinfections do not appear to strongly influence the clinical manifestations of uncomplicated ZIKV infections. Further research is needed to confirm whether risk of severe complications is altered when ZIKV infection co-occurs with other infections.PROSPERO registration numberCRD42018111023.

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Section: Introductionmentioning

confidence: 99%

The frequency and clinical presentation of Zika virus coinfections: a systematic review

et al. 2020

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“…So far, in Honduras only 8 cases of congenital Zika syndrome (CSZ) have been reported. But this deserve further careful studies about in order to assess the frequency of ZIKV infection during pregnancy in the country and the association of microcephaly and other birth defects with ZIKV infection [20], as has been reported in Brazil and Colombia, among other countries in Latin America [46,47].…”

Section: Discussionmentioning

confidence: 97%

Spatial Distribution of Zika in Honduras during 2016–2017 Using Geographic Information Systems (GIS)—Implications in Public Health and Travel Medicine

Vasquez-Bonilla¹,

Zambrano²,

Valle-Reconco³

et al. 2018

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Background: Zika virus (ZIKV) infection has affected significantly Latin America in 2015–2017. However, most studies have been reported from Brazil and Colombia, but few of them in Central America. For these reasons we analyzed the incidence, incidence rates and evolution of cases of Honduras during 2016–2017. Methods: Using epidemiological weeks (EW) surveillance data on the ZIKV epidemics in Honduras, we estimated incidence rates (cases/100,000 population), and developed maps at national, departments and municipal levels. Results: From January 1, 2016 to December 31, 2017, a total of 32,607 cases of Zika were reported (98.5% in 2016 for an incidence rate of 36.85 cases/100,000 pop; 1% confirmed by RT-PCR). The highest peak was reached on the EW 6°, 2016 (2,559 cases; 29.34 cases/100,000 pop). The department with the highest number of cases and incidence rate was Cortés (13,128 cases, 791.08 cases/100,000 pop in 2016). Discussion: Pattern and evolution of Zika in Honduras has been like those that occurred for chikungunya in 2015, that we analyzed and previously reported, affecting predominantly the central and capital area of the country, reaching also high incidences there >750 cases/100,000 pop. Studies using geographical information systems, to map its epidemiology, as well on the clinical aspects linked to, are necessary in this country, as well for the assessment of risk for travelers who visit specific areas in a destination country.

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“…Whether this underestimate in the microcephaly rate would also affect the estimate of IAR would depend on the influence of the other data types on the total likelihood. The risk of microcephaly or CZS has been estimated as 0.95% (95% CI: 0.34-1.91%) during the first trimester in French Polynesia [ 54 ], 2.3% (2 out of 86 births) in Colombia [ 55 ], and 5% (95% CI: 4-7%) among fetuses and infants born to women with laboratory-confirmed ZIKV infection in the U.S. territories [ 47 ]. In a cohort study in Rio de Janerio, 42% of children born to ZIKV-infected mothers were found to have central nervous system abnormalities, although only 4 of 117 were diagnosed with microcephaly [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Leveraging multiple data types to estimate the size of the Zika epidemic in the Americas

et al. 2020

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Several hundred thousand Zika cases have been reported across the Americas since 2015. Incidence of infection was likely much higher, however, due to a high frequency of asymptomatic infection and other challenges that surveillance systems faced. Using a hierarchical Bayesian model with empirically-informed priors, we leveraged multiple types of Zika case data from 15 countries to estimate subnational reporting probabilities and infection attack rates (IARs). Zika IAR estimates ranged from 0.084 (95% CrI: 0.067-0.096) in Peru to 0.361 (95% CrI: 0.214-0.514) in Ecuador, with significant subnational variability in every country. Totaling infection estimates across these and 33 other countries and territories, our results suggest that 132.3 million (95% CrI: 111.3-170.2 million) people in the Americas had been infected by the end of 2018. These estimates represent the most extensive attempt to determine the size of the Zika epidemic in the Americas, offering a baseline for assessing the risk of future Zika epidemics in this region.

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Diagnosis and outcomes of pregnant women with Zika virus infection in two municipalities of Risaralda, Colombia: Second report of the ZIKERNCOL study

Cited by 30 publications

References 69 publications

The frequency and clinical presentation of Zika virus coinfections: a systematic review

The frequency and clinical presentation of Zika virus coinfections: a systematic review

Spatial Distribution of Zika in Honduras during 2016–2017 Using Geographic Information Systems (GIS)—Implications in Public Health and Travel Medicine

Leveraging multiple data types to estimate the size of the Zika epidemic in the Americas

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Diagnosis and outcomes of pregnant women with Zika virus infection in two municipalities of Risaralda, Colombia: Second report of the ZIKERNCOL study

Cited by 30 publications

References 69 publications

The frequency and clinical presentation of Zika virus coinfections: a systematic review

The frequency and clinical presentation of Zika virus coinfections: a systematic review

Spatial Distribution of Zika in Honduras during 2016&ndash;2017 Using Geographic Information Systems (GIS)&mdash;Implications in Public Health and Travel Medicine

Leveraging multiple data types to estimate the size of the Zika epidemic in the Americas

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Spatial Distribution of Zika in Honduras during 2016–2017 Using Geographic Information Systems (GIS)—Implications in Public Health and Travel Medicine