Diagnosis and pharmacotherapy of severe acute respiratory syndrome: what have we learnt?

Tsang, Kenneth W.

doi:10.1183/09031936.04.00092004

Cited by 18 publications

(20 citation statements)

References 59 publications

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“…Critical-illness-associated polyneuropathy/myopathy has also been observed in a few SARS survivors [147]. The reported incidence rates of avascular necrosis of bone among different cohorts in Hong Kong range from 4.7-15 % [124,148,149], whereas one study from Beijing reported a high incidence of 42 % [123].…”

Section: Long-term Outcomementioning

confidence: 94%

SARS: clinical presentation, transmission, pathogenesis and treatment options

2006

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SARS (severe acute respiratory syndrome) appeared as the first emerging infectious disease of this century. It is fortunate that the culprit virus can be grown without much difficulty from a commonly used cell line, allowing an unlimited supply of isolates for further molecular studies and leading to the development of sensitive diagnostic assays. How the virus has successfully jumped the species barrier is still a mystery. The superspreading events that occurred within hospital, hotel and high-density housing estate opens a new chapter in the mechanisms and routes of virus transmission. The old practice of quarantine proved to be still useful in controlling the global outbreak. Despite all the available sophisticated tests, alertness with early recognition by healthcare workers and prompt isolation of suspected cases is still the most important step for containing the spread of the infection. Although the rapidly evolving outbreak did not allow the conducting of systematic clinical trails to evaluate treatment options, the accumulated experience on managing SARS patients will improve the clinical outcome should SARS return. Although SARS led to more than 700 deaths worldwide, the lessons learnt have prepared healthcare systems worldwide to face future emerging and re-emerging infections.

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Section: Long-term Outcomementioning

confidence: 94%

SARS: clinical presentation, transmission, pathogenesis and treatment options

2006

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“…At fever onset, 80% of SARS patients have airspace consolidation, especially peripheral and lower zone in distribution, on their chest radiographs Tsang et al, 2004). Generally, rapid deterioration of ground-glass consolidation occurs in the first 3 days, peaking between 8 and 10 days after onset of fever to become multilobar and bilateral (Figure 1).…”

Section: Clinical Featuresmentioning

confidence: 99%

Severe Acute Respiratory Syndrome (SARS)

Tsang

2017

International Encyclopedia of Public Health

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“…153,154 Critical illness associated polyneuropathy/mypoathy was also observed in a few SARS survivors. 155 The reported incidence rates of avascular necrosis of bone among different cohorts in HK ranged from 4.7% to 15%, 156,157 whereas 1 study from Beijing reported a high incidence of 42%. 133 Several other groups have shown that persistent lung function abnormalities occur in less than one-third of patients at 1 year and that there was significant impairment of health status among SARS survivors and their carers.…”

Section: Short-termmentioning

confidence: 99%

Severe Acute Respiratory Syndrome and Coronavirus

Hui

Chan

2010

Infectious Disease Clinics of North America

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Severe acute respiratory syndrome (SARS) is a highly infectious disease with a significant morbidity and mortality. Respiratory failure is the major complication, and patients may progress to acute respiratory distress syndrome. Health care workers are particularly vulnerable to SARS. SARS has the potential of being converted from droplet to airborne transmission. There is currently no proven effective treatment of SARS, so early recognition, isolation, and stringent infection control are the key to controlling this highly contagious disease. Horseshoe bats are implicated in the emergence of novel coronavirus infection in humans. Further studies are needed to examine host genetic markers that may predict clinical outcome.

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Diagnosis and pharmacotherapy of severe acute respiratory syndrome: what have we learnt?

Cited by 18 publications

References 59 publications

SARS: clinical presentation, transmission, pathogenesis and treatment options

SARS: clinical presentation, transmission, pathogenesis and treatment options

Severe Acute Respiratory Syndrome (SARS)

Severe Acute Respiratory Syndrome and Coronavirus

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