Diagnosis and Prevalence of Lanolin Allergy

Miest, Rachel Y.; Yiannias, James A.; Chang, Yu Hui; Singh, Nidhi

doi:10.1097/der.0b013e3182937aa4

Cited by 29 publications

(46 citation statements)

References 23 publications

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“…We confirmed that adding Amerchol L101 to lanolin alcohol in routine patch testing has additional diagnostic value in detecting lanolin contact allergy . The highest prevalence of positive reactions was observed for both lanolin alcohol and Amerchol L101.…”

Section: Discussionsupporting

confidence: 76%

“…Moreover, the patients were referred for tertiary care. As a result, the prevalence of patients with lanolin contact allergy (28.6%, 95%CI: 25.1%‐32.3%) is higher than is normally reported . The positive association between atopic dermatitis and lanolin contact allergy has previously been reported .…”

Section: Discussionmentioning

confidence: 79%

“…Particular attention is being payed to Amerchol L101 50% pet., which is a mixture of 10% lanolin alcohols and mineral oil . Several studies reported more reactions to Amerchol L101 than to lanolin alcohol . Moreover, in a recent multicentre study, a group of 79 969 patients were simultaneously tested with both lanolin alcohol and Amerchol L101: more patients reacted only to Amerchol L101 (2.05%) than only to lanolin alcohol (1.19%) ( P < 0.001).…”

Section: Introductionmentioning

confidence: 97%

“…Atopic dermatitis, leg ulcers and lower‐extremity venous stasis dermatitis have been identified as risk factors for the development of lanolin contact allergy . The reported prevalence of lanolin sensitization in referred dermatitis patients has varied from 1.2% to 6.9% between several studies . Lanolin alcohol 30% pet.…”

Section: Introductionmentioning

confidence: 99%

“…is the standard patch test agent for diagnosing lanolin contact allergy, and has been included in the European baseline series (EBS) since 1969 . However, supplementary patch testing with other lanolin derivatives seems to improve the identification of lanolin‐sensitive patients . Particular attention is being payed to Amerchol L101 50% pet., which is a mixture of 10% lanolin alcohols and mineral oil .…”

Section: Introductionmentioning

confidence: 99%

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Diagnosing lanolin contact allergy with lanolin alcohol and Amerchol L101

2019

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Background The prevalence of lanolin contact allergy in dermatitis patients varies from 1.2% to 6.9%. Different lanolin derivatives are used in patch testing. Objectives To determine which combination of lanolin derivatives is most effective in patch testing for the diagnosis of lanolin contact allergy. Methods A retrospective analysis of patients patch tested between 2016 and 2017 was performed. Patients were eligible if they had been tested with lanolin alcohol 30% pet., Amerchol L101 50% pet., and a supplementary series containing other lanolin derivatives. Lanolin alcohol and Amerchol L101 were tested in duplicate. Results Of 594 patients, 28.6% (95% confidence interval [CI]: 25.1%‐32.3%) had a positive patch test reaction to at least one lanolin derivative. Reactions to lanolin alcohol (14.7%, 95%CI: 11.3%‐18.2%) and Amerchol L101 (15.0%, 95%CI: 11.5%‐18.5%) were common in the routinely tested series. Reactions to other test preparations were significantly less frequent ( P < 0.05). The addition of Amerchol L101 to lanolin alcohol significantly increased the number of positive cases (odds ratio 1.79, P < 0.001). Conclusions The combination of lanolin alcohol and Amerchol L101 is effective in patch testing for the diagnosis of lanolin contact allergy. Routinely testing with other lanolin derivatives may not be worthwhile, as it detects only a few additional patients.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnosing lanolin contact allergy with lanolin alcohol and Amerchol L101

2019

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Allergic Contact Dermatitis

Wilkinson,

Orton

2016

Rook's Textbook of Dermatology, Ninth Edition

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Allergic contact dermatitis is the classic delayed hypersensitivity reaction, developing in two phases – sensitization and elicitation. It can have profound effects on affected individuals and may result in sickness, absence from work and increased health expense. Its diagnosis requires consideration of many factors including the patient's history and a physical examination; knowledge of the skin's reaction to various chemicals is also desirable. Above all, it requires a high degree of suspicion on the part of the clinician and tenacity, skill and experience in the investigator. The diagnosis can only be confirmed by interpreting patch test results and the technique in itself has many pitfalls for the unwary. Any sensitization identified needs to be put into the context of a past or present dermatitis, and explanations for allergen avoidance or substitution need to be provided for the patient.

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Neonatal Skin Care

Hoeger

2019

Harper's Textbook of Pediatric Dermatology

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Diagnosis and Prevalence of Lanolin Allergy

Abstract: Amerchol L101 and patients' own products should be added to a standard patch testing allergen series to adequately identify lanolin allergy.

Cited by 29 publications

References 23 publications

Diagnosing lanolin contact allergy with lanolin alcohol and Amerchol L101

Diagnosing lanolin contact allergy with lanolin alcohol and Amerchol L101

Allergic Contact Dermatitis

Neonatal Skin Care

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