Diagnosis and Prognosis in Lumbar Disc Herniation

Vucetic, N; Åstrand, Per; Güntner, Peter; Svensson, Olle

doi:10.1097/00003086-199904000-00016

Cited by 85 publications

(61 citation statements)

References 24 publications

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“…Miller et al (1988) studied 600 disc specimens from 237 cadavers, and reported that disc degeneration was detected in 16% of patients who died in their 20s, while disc degeneration was detected in 98% of patients who died in their 70s. At the time, men of all ages exhibited greater disc degeneration compared to women, and similar results have been reported from studies using magnetic resonance imaging (MRI) and surgery (Goh S et al, 2000;Vucetic et al, 1999). In addition, other studies have reported a correlation between obesity and disc degeneration (Like et al, 2005;Rodacki et al, 2005, Hangai et al, 2008.…”

Section: Age Sex and Body Weightsupporting

confidence: 66%

Effect of Workload on Musculoskeletal Degeneration

Kim¹,

Kim²,

Kang³

et al. 2014

Journal of the Ergonomics Society of Korea

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Objectiv e: The aim of this study is to investigate the effect of workload on musculoskeletal degeneration. Background:It is important that workers maintain a health body for a long time as a measure of aging workers. In order do so, it is necessary to find out if workload can effect on musculoskeletal degeneration.Method: Epidemiological studies on workload or occupation and disc degeneration, osteoarthritis of knee were identified through database and bibliography searches.Results: Epidemiological studies showed that workload certainly effect on musculoskeletal degeneration. But we couldn't know which of individual factors and occupational factors further contribute to the musculoskeletal degeneration. And we could find that studies on workload and genetic factors were very few. In addition, there was also very few studies that it was possible interaction between individual factors as obesity and occupational factors as heavy manual lifting.Conclusion: Our reviews suggest that it need to conduct study between workload and genetic factors for musculoskeletal degeneration. This further study can identify attributable risk of workload for musculoskeletal degeneration, and contribute to the measure of aging workers.Application: This paper can help to establish research plan for the measure of aging workers.

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Section: Age Sex and Body Weightsupporting

confidence: 66%

Effect of Workload on Musculoskeletal Degeneration

Kim¹,

Kim²,

Kang³

et al. 2014

Journal of the Ergonomics Society of Korea

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“…Regarding lumbar disc herniations, a few contradictory reports exist (Rasmussen 1996, Loupasis et al 1999, Vucetic et al 1999, Jansson et al 2005. This was our incitement to study differences between the sexes in a large unselected group of patients who were operated for painful disc herniations.…”

Section: Discussionmentioning

confidence: 99%

Gender differences in lumbar disc herniation surgery

Strömqvist¹,

Ahmad²,

Hildingsson³

et al. 2008

Acta Orthopaedica

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Background and purpose Although there have been numerous publications on lumbar disc herniation (LDH) treated surgically, there has been little interest in sex differences. It has been shown in many studies that sex differences may be important in certain diseases. We therefore reviewed consecutive register material from one institution for possible gender differences in preand postoperative parameters in patients operated for lumbar disc herniation.Patients and methods Pre-and postoperative parameters for all patients operated on at the Department of Orthopedics, Lund University Hospital over 6 years (2000-2005 inclusive) (301 patients, 165 males) were analyzed regarding sex differences.Results Statistically significant and clinically relevant sex differences were found. Preoperatively, females had more pronounced back pain and disability, and also lower quality of life in some respects. At 1-year followup, females reported a higher rate of consumption of analgesics, a higher degree of postoperative back and leg pain, and less improvement regarding disability and some aspects of quality of life. Relative improvement, rate of return to work, and satisfaction with the outcome of surgery were not, however, statistically significantly different between females and males.Interpretation There are statistically significant differences between the sexes in lumbar disc herniation surgery regarding basic demographic status and postoperative status, whereas the surgical effect is similar. Further investigations should focus on whether there is a true sex difference or whether these differences are due to selection for surgery, differences in proneness to seek medical advice or to accept/choose surgery, or other unknown factors.

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“…Clinically, mechanical compression of the lumbar spinal nerve roots, either by disc prolapse or spinal stenosis, is a common mechanism of painful lumbar radiculopathy [7,27,35]. Though the symptoms and physical sign are clear in clinic, but the pathophysiology of the back pain and radiculopathy associated with lumbar stenosis and lumbar disc herniations is incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

A rat model for chronic spinal nerve root compression

et al. 2013

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Objectives The pathophysiology of radiculopathy associated with lumbar spinal stenosis and lumbar disc herniation is incompletely understood. The goal of the present study was to establish a chronic spinal nerve root compression model that can mimic lumbar disc herniation or spinal stenosis using silicone tube compression. We also try to link the pathology changes of damaged nerve root with the reaction of microglia in spinal cord in same rat at different time points. Methods Thirty rats were used in this study. The L5 nerve roots (dorsal and ventral) were exposed by hemilaminectomy; the diameter of the L5 nerve root was measured at the 2 mm proximal from the dorsal root ganglia. The dorsal and ventral nerve roots of L5 were compressed using a silicone tube, and the sham group was only exposed dorsal and ventral roots of L5. Five rats from the sham group were perfused at 8 days after surgery, and 25 rats from the model groups were perfused at 3, 8, 12, 45 days, and 5 months after surgery, each model group was composed of 5 rats according to the time point. The L5 spinal cord segments and nerve root that compressed by silicone tube were harvested from the same rat. Microglia and neuron in the spinal cord were stained by immunohistochemistry, and the nerve root was shown by electron microscope. Results In sham-operated rat, the arrangement of axon and myelin sheath is normal, the ventral root is mainly composed of large axon ([6 lm) and it is composed of 46.3 % of all the axons of the ventral root; the average myelin thickness of large axon is 1.86 lm; the dorsal root is mainly composed of medium (2-3.9 or 4-5.9 lm) axons and they are composed of 79.1 % of all the axons of the dorsal root; the average myelin thickness of this category is 0.94 or 1.55 lm. The average myelin thickness of large axon in ventral root reduced to 0.97 and 1.19 lm from more than 1.86 lm after compression for 3 and 8 days separately. Most of myelin sheath disappeared after 12 days of compression; the myelin sheath was partly restored at 45 days after compression which the myelin sheath thickness of large axons in ventral root was 0.47 lm. The medium category in dorsal root reduced to 0.59 or 0.72 lm from 0.94 lm, and 1.55 lm after compression for 3 days (p \ 0.05 to p \ 0.0001). The medium category axon in dorsal root is also 0.47 lm after compression for 45 days (p B 0.0001). The myelin sheath was almost totally restored at the 5 months of compression; the myelin sheath thickness returned to normal and the axons were intact in structure under EM. The number of Iba1-positive microglia increased by 18.69, 40.44, and 18.49 % after compression for 3, 8, and 12 days separately in the ipsilateral dorsal horn and 21.26, 32.15, 22.87 % in ventral horns, and the activation of microglia was also prominent in contralateral sides of the dorsal and ventral horn at

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Diagnosis and Prognosis in Lumbar Disc Herniation

Cited by 85 publications

References 24 publications

Effect of Workload on Musculoskeletal Degeneration

Effect of Workload on Musculoskeletal Degeneration

Gender differences in lumbar disc herniation surgery

A rat model for chronic spinal nerve root compression

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