Diagnosis and therapy of genetic haemochromatosis (review and 2017 update)

Fitzsimons, Edward J.; Cullis, Jonathan O.; Thomas, Dafydd; Tsochatzis, E.; Griffiths, William J.

doi:10.1111/bjh.15164

Cited by 47 publications

(88 citation statements)

References 43 publications

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“…All participants had ferritin values in the normal range for the UK (15-300 µg/L-men and 15-200 µg/L-women) [63]. The 2011 WHO guidelines state that serum ferritin less than 15 µg/L is a specific indicator for iron deficiency [78].…”

Section: Discussionmentioning

confidence: 99%

Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults

et al. 2020

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Brain-derived neurotrophic factor (BDNF) is key for the maintenance of normal neuronal function and energy homeostasis and has been suggested to improve cognitive function, including learning and memory. Iron and the antioxidant curcumin have been shown to influence BDNF homeostasis. This 6-week, double blind, randomized, placebo-controlled study examined the effects of oral iron supplementation at low (18 mg) and high (65 mg) ferrous (FS) iron dosages, compared to a combination of these iron doses with a bioavailable formulated form of curcumin (HydroCurcTM; 500 mg) on BDNF levels in a healthy adult cohort of 155 male (26.42 years ± 0.55) and female (25.82 years ± 0.54) participants. Participants were randomly allocated to five different treatment groups: both iron and curcumin placebo (FS0+Plac), low dose iron and curcumin placebo (FS18+Plac), low dose iron and curcumin (FS18+Curc), high dose iron and curcumin placebo (FS65+Plac) and high dose iron and curcumin (FS65+Curc). Results showed a significant increase in BDNF over time (26%) in the FS18+Curc group (p = 0.024), and at end-point between FS18+Curc and FS18+Plac groups (35%, p = 0.042), demonstrating for the first time that the combination with curcumin, rather than iron supplementation alone, results in increased serum BDNF. The addition of curcumin to iron supplementation may therefore provide a novel approach to further enhance the benefits associated with increased BDNF levels.

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Section: Discussionmentioning

confidence: 99%

Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults

et al. 2020

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“…The ability to use MRI to quantify liver iron concentration and the presence of non-invasive serologic markers for fibrosis prediction (serum ferritin, platelets, transaminases), have diminished the diagnostic need for biopsy in haemochromatosis. Genetic testing is required to differentiate true genetic hemochromatosis (homozygous C282Y) from the other forms of milder hemochromatosis or even secondary iron overload syndromes [ 22 , 119 ]. Recent studies have identified elevated iron without homozygosity for the p.C282Y variant in the HFE gene, highlighting the continued undetected disease existing in the general population [ 120 – 122 ].…”

Section: Applications Of Mpmri In Chronic Liver Diseasementioning

confidence: 99%

“…Recent studies have identified elevated iron without homozygosity for the p.C282Y variant in the HFE gene, highlighting the continued undetected disease existing in the general population [ 120 – 122 ]. Increased iron can be co-existing in NAFLD, ALD and other chronic liver diseases [ 22 , 122 , 123 ]. Elevated liver iron has been reported in NALFD cohorts at prevalence that ranges between 10–34.5%, based on histochemical staining [ 40 , 102 , 124 – 126 ].…”

Section: Applications Of Mpmri In Chronic Liver Diseasementioning

confidence: 99%

“…This can lead to disease mismanagement or complications for the patient that an imaging test has the potential to avoid. In genetic haemochromatosis, the guidelines centre around early detection and monitoring via blood tests and confirmation, if necessary, with biopsy [22].…”

Section: Introductionmentioning

confidence: 99%

“…Recent developments suggest that mpMRI could bridge some of these diagnostic gaps, the biggest impact being to obviate the need for histological assessment of disease activity and staging via liver biopsy in many clinical disease states [22,[27][28][29][30][31][32][33][34][35][36]. It is only a matter of time before liver mpMRI enables clinical practice transformation, following in the footsteps of success stories already seen in breast cancer, prostate cancer and cardiology [37][38][39].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Multiparametric MR mapping in clinical decision-making for diffuse liver disease

Thomaides-Brears¹,

Lepe

Banerjee³

et al. 2020

Abdom Radiol

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Accurate diagnosis, monitoring and treatment decisions in patients with chronic liver disease currently rely on biopsy as the diagnostic gold standard, and this has constrained early detection and management of diseases that are both varied and can be concurrent. Recent developments in multiparametric magnetic resonance imaging (mpMRI) suggest real potential to bridge the diagnostic gap between non-specific blood-based biomarkers and invasive and variable histological diagnosis. This has implications for the clinical care and treatment pathway in a number of chronic liver diseases, such as haemochromatosis, steatohepatitis and autoimmune or viral hepatitis. Here we review the relevant MRI techniques in clinical use and their limitations and describe recent potential applications in various liver diseases. We exemplify case studies that highlight how these techniques can improve clinical practice. These techniques could allow clinicians to increase their arsenals available to utilise on patients and direct appropriate treatments.

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The liver and gallbladder in the geriatric population

Trey¹

2022

Pathy's Principles and Practice of Geriatric Medicine

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Diagnosis and therapy of genetic haemochromatosis (review and 2017 update)

Cited by 47 publications

References 43 publications

Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults

Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults

Multiparametric MR mapping in clinical decision-making for diffuse liver disease

The liver and gallbladder in the geriatric population

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