Diagnosis and Therapy of ulcerative Colitis: Results of an Evidence Based Consensus Conference by the German Society of Digestive and Metabolic Diseases and the Competence Network on Inflammatory Bowel Disease

Hoffmann, Jörg; Zeitz, Martin; Bischoff, Stephan C.; Brambs, Hans‐Jürgen; Bruch, Hans–Peter; Buhr, HJ; Dignaß, Axel; Fischer, Imma; Fleig, W E; Fölsch, Ulrich R.; Herrlinger, Klaus; Höhne, W; Jantschek, Günter; Kaltz, Birgit; Keller, K. M.; Knebel, U; Kroesen, A. J.; Kruis, Wolfgang; Matthes, Harald; Moser, Gabriele; Mundt, Steven S.; Pox, Christian; Reinshagen, Max; Reissmann, A.; Riemann, J.F.; Rogler, Gerhard; Schmiegel, Wolff; Schölmerich, Jürgen; Schreiber, Stefan; Schwandner, O.; Selbmann, H. K.; Stange, E. F.; Utzig, Monika; Wittekind, Ch.

doi:10.1055/s-2004-813510

Cited by 68 publications

(20 citation statements)

References 11 publications

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“…It should be emphasized here that this time-point is referred to the initial symptoms and not to the first diagnosis, as patients might have had the disease for several years before being diagnosed. In patients with extensive colitis, it is recommended that surveillance should start after screening colonoscopy (8–10 years after onset of disease) and then be performed every other year up to year 20 of disease, then annually or annually from 10 years of disease duration on [16,17,30,31,37]. …”

Section: When and How Should Surveillance Colonoscopy Be Performed?mentioning

confidence: 99%

“…Patients who still have left-sided colitis should start surveillance 15 years after first manifestation [16,17,30,31,37]. Patients with extension to pancolitis should have their surveillance colonoscopy every 2 years after the index colonoscopy at 8 years (as mentioned above for extensive disease).…”

Section: When and How Should Surveillance Colonoscopy Be Performed?mentioning

confidence: 99%

“…Patients with extension to pancolitis should have their surveillance colonoscopy every 2 years after the index colonoscopy at 8 years (as mentioned above for extensive disease). In all guidelines the consensus on this strategy is strong [17,31,37] despite the lack of robust efficacy data.…”

Section: When and How Should Surveillance Colonoscopy Be Performed?mentioning

confidence: 99%

“…Mathematical modeling was done by Rubin et al [53] indicating that 34 random biopsies will result in a 90% CI to detect CRC or high-grade dysplasia, 64 biopsies will be necessary for a 95% probability of detection. Despite the fact that this is only a model based on a questionable basis and that the evidence is weak, similar numbers for random biopsies during surveillance colonoscopy can now be found in a number of guidelines [31,37]. To achieve a 90% security for the detection of dysplasia/neoplastic lesions, it is recommended that 4 biopsies are taken every 10 cm.…”

Section: How Should Surveillance Colonoscopies Be Performed?mentioning

confidence: 99%

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Inflammatory Bowel Disease Cancer Risk, Detection and Surveillance

Rogler

2012

Dig Dis

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Ulcerative colitis (UC) is a chronic and relapsing inflammation of the colonic mucosa with variable extension from the rectum towards the cecum. The aim of medical treatment is to induce and maintain clinical remission. If no remission can be achieved, continuous inflammation may repeatedly destroy the epithelial cells. This has to be compensated by epithelial increased proliferation which finally can lead to inflammation-associated colorectal cancer (CRC). The risk of colitis-associated CRC is increased after a long disease duration, especially in patients with chronic active disease. This risk may be lower if long-lasting mucosal healing can be achieved. To detect the development of dysplasia/intraepithelial neoplasia and colitis-associated CRC early, surveillance programs have been installed. However, the evidence of success for those surveillance programs is limited. This is partially due to problems of detecting precancerous lesions in the colonic mucosa during those surveillance programs. The specific problems of surveillance programs for the prevention of CRC and specific aspects of patient care in UC are reviewed in this article.

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Section: When and How Should Surveillance Colonoscopy Be Performed?mentioning

confidence: 99%

Section: When and How Should Surveillance Colonoscopy Be Performed?mentioning

confidence: 99%

Section: When and How Should Surveillance Colonoscopy Be Performed?mentioning

confidence: 99%

Section: How Should Surveillance Colonoscopies Be Performed?mentioning

confidence: 99%

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Inflammatory Bowel Disease Cancer Risk, Detection and Surveillance

Rogler

2012

Dig Dis

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“…In CT enterogrpahy, there have been concerns on side effects of contrast agent and ionizing radiation particularly for young patients of reproductive age requiring multiple imaging studies over time. On the other hand, MRE is a radiation-free alternative method to CTE providing real time and functional images by using multiphase sequences [1][2][3][4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of a Turbo Direction Change for Reduction of Motion Artifact in Magnetic Resonance Enterography

Choi¹,

Son²,

Jeong³

2016

Journal of Magnetics

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The purpose of this study is to evaluate an effectiveness of switching turbo direction to improve motion artifacts of small bowels and aorta. From June to October 2015, 60 patients suspected of having Crohn's disease were enrolled. The MR Enterography scans were performed using same protocol other than the turbo direction: with the Z phase encoding (group A) and with Y phase encoding (group B). Qualitative analysis of each group was performed to evaluate the effectiveness of switching turbo direction from Z to Y. As a result, the 5-point Likert scale for paired observers were 2.33±0.88 for group A and 3.80±0.85 for group B on dynamic contrast enhanced coronal images. In conclusion, group B is proved to be superior to group A and can lessen the motion artifacts derived from phase shifts.

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Clinical use of E. coli Nissle 1917 in inflammatory bowel disease

Schultz

2008

Inflammatory Bowel Diseases

265

187

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The probiotic Escherichia coli strain Nissle 1917 is in addition to some Lactobacilli sp. one of the best-studied probiotic strains. This particular E. coli strain was isolated in 1917 based on its potential to protect from presumably infectious gastroenteritis. Initial therapeutic success was noted in the management of gastrointestinal infectious disorders and infections affecting the urinary tract; the focus shifted later to chronic inflammatory conditions. The unique combination of fitness and survival factors to support intestinal survival, the lack of virulence, and obvious probiotic properties make this microorganism a safe and effective candidate in the treatment of chronic inflammatory bowel diseases. Three large clinical trials have assessed the potential in the maintenance of remission of ulcerative colitis and equivalence to standard 5-ASA medication was documented. This review aims to discuss important mechanisms of E. coli Nissle 1917 and will review the available literature regarding treatment of inflammatory bowel diseases.

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Diagnosis and Therapy of ulcerative Colitis: Results of an Evidence Based Consensus Conference by the German Society of Digestive and Metabolic Diseases and the Competence Network on Inflammatory Bowel Disease

Cited by 68 publications

References 11 publications

Inflammatory Bowel Disease Cancer Risk, Detection and Surveillance

Inflammatory Bowel Disease Cancer Risk, Detection and Surveillance

Effectiveness of a Turbo Direction Change for Reduction of Motion Artifact in Magnetic Resonance Enterography

Clinical use of E. coli Nissle 1917 in inflammatory bowel disease

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