Diagnosis and treatment control of choroidal melanomas ‐ the role of B‐scan and Doppler‐technique

Guthoff, Rudolf; Winkler, Peter; Helmke, K.; Berger, R. W.

doi:10.1111/j.1755-3768.1992.tb04926.x

Cited by 11 publications

(6 citation statements)

References 5 publications

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“…However, it is still a great challenge to image eye anatomy and pathology without artifacts. Ultrasound is the ophthalmologist's standard imaging tool for evaluating intraorbital structures [1] , [2] . Other diagnostic techniques that can provide useful additional information include fluorescence angiography (FAG) [3] , ultrasound biomicroscopy (UBM) [4] , optical coherence tomography (OCT) [5] , computed tomography (CT) [6] , and magnetic resonance imaging (MRI) [7] .…”

Section: Introductionmentioning

confidence: 99%

Experimental Differentiation of Intraocular Masses Using Ultrahigh-Field Magnetic Resonance Imaging – A Case Series

et al. 2013

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PurposeThe case reports presented here were compiled to demonstrate the potential for improved diagnosis and monitoring of disease progress of intraocular lesions using ultrahigh-field magnetic resonance microscopy (MRM) at 7.1 Tesla.MethodsHigh-resolution ex vivo ocular magnetic resonance (MR) images were acquired on an ultrahigh-field MR system (7.1 Tesla, ClinScan, Bruker BioScan, Germany) using a 2-channel coil with 4 coil elements and T2-weighted turbo spin echo (TSE) sequences of human eyes enucleated because of different intraocular lesions. Imaging parameters were: 40×40 mm field of view, 512×512 matrix, and 700 µm slice thickness. The results were correlated with in vivo ultrasound and histology of the enucleated eyes.ResultsImaging was performed in enucleated eyes with choroidal melanoma, malignant melanoma of iris and ciliary body with scleral perforation, ciliary body melanoma, intraocular metastasis of esophageal cancer, subretinal bleeding in the presence of perforated corneal ulcer, hemorrhagic choroidal detachment, and premature retinopathy with phthisis and ossification of bulbar structures. MR imaging allowed differentiation between solid and cystic tumor components. In case of hemorrhage, fluid-fluid levels were identified. Melanin and calcifications caused significant hypointensity. Microstructural features of eye lesions identified by MRM were confirmed by histology.ConclusionThis study demonstrates the potential of MRM for the visualization and differential diagnosis of intraocular lesions. At present, the narrow bore of the magnet still limits the use of this technology in humans in vivo. Further advances in ultrahigh-field MR imaging will permit visualization of tumor extent and evaluation of nonclassified intraocular structures in the near future.

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Section: Introductionmentioning

confidence: 99%

Experimental Differentiation of Intraocular Masses Using Ultrahigh-Field Magnetic Resonance Imaging – A Case Series

et al. 2013

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“…Malignant melanoma’s ultrasonographic characteristics are its size, shape, dense composition, low reflectivity, mostly homogenous structure, and vascularization. 8 Its typical MRI appearance consists of high signal intensity on T1-weighted (T1-WI) sequence and low signal intensity on T2-weighted (T2-WI) sequence, due to the paramagnetic properties of melanin. Mild-to-moderate arterial enhancement after intravenous (IV) bolus administration of paramagnetic contrast agent is also noted.…”

Section: Introductionmentioning

confidence: 99%

Investigation into the quantitative and qualitative characteristics of choroidal melanoma through magnetic resonance imaging and B-scan ultrasound

Papayiannis

Tsaousis

Kouskouras

et al. 2017

OPTH

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ObjectiveTo investigate the homogeneity and vascularity of choroidal melanoma through magnetic resonance imaging (MRI) and brightness modulation (B-mode) ultrasound scan and their correlation with dimensions of tumor, as well as to measure the sensitivity of both modalities in retinal detachment (RD) detection.Materials and methodsThis retrospective chart review included patients diagnosed with choroidal melanoma. All these patients underwent MRI scans using T2-weighted (T2-WI) and T1-weighted (T1-WI) sequences, before and after an intravenous injection of paramagnetic contrast material. The patients were also examined using a B-mode ultrasound scan, and the results from both modalities were compared (tumor homogeneity, tumor height, tumor base diameter, and tumor vascularity).ResultsForty-two patients (mean age=65.33±12.51 years) with choroidal melanoma were included in the study. Homogeneity was confirmed in 16 patients through ultrasound scan, in 19 patients through T1-WI sequence, in 21 patients through T2-WI sequence, and in 25 patients through T1-WI sequence + contrast (gadolinium). Patients with homogenous tumors presented with lower (P=0.0045) mean height than that of those with nonhomogenous tumors, whereas no statistically significant difference was found for base diameter measurements (P=0.056). Patients with tumors of high vascularity presented with greater mean height (P=0.000638) and greater mean base diameter compared with those with tumors of low vascularity (P=0.019543). RD was detected in 26 patients through T1-WI sequence, in 13 patients through T2-WI sequence, in 26 patients through T1-WI sequence + contrast, and in 32 patients through ultrasound scan, which proved to be the most sensitive modality.ConclusionThe height of choroidal melanoma was positively correlated with tumor’s homogeneity. Melanomas of greater height were found to be less homogenous, due to increased degeneration and higher occurrence of intratumoral hemorrhage. In addition, choroidal melanoma’s height was also positively correlated with the level of its vascularity. Finally, ultrasound scan was found to be more sensitive than MRI in the detection of RD.

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“…Evidence for increased blood flow in uveal tumours has been provided by A‐ and B‐mode ultrasound, fluorescein angiography (FA) and indocyanine green angiography (Edwards et al. 1969; Hayreh 1970; Guthoff et al. 1991, 1992; Folberg et al.…”

Section: Introductionmentioning

confidence: 99%

Choroidal perfusion in eyes with untreated choroidal melanoma

Resch

Garhöfer

Schmetterer

et al. 2008

Acta Ophthalmologica

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. Purpose: Previous studies indicate that ocular blood flow is altered in eyes with choroidal melanoma. In the present study pulsatile ocular blood flow (POBF) was assessed to investigate whether there exists a correlation between tumour size and ocular blood flow parameters. Methods: Twenty‐two patients with unilateral untreated choroidal melanoma were studied using two measurement techniques: POBF was measured with a pneumotonometer and local foveal fundus pulsation amplitude (FPA) by laser interferometry, and results were correlated. Tumour volume was calculated using the ellipsoidal solid model and was correlated to POBF and FPA. Results: Levels of POBF and FPAs tended to be higher in tumour eyes compared with unaffected eyes, but the differences did not reach the level of significance. Both methods showed a high degree of correlation in unaffected eyes. In tumour eyes the correlation was slightly less pronounced. There was no correlation between tumour and POBF or FPA. Conclusions: Our results do not indicate choroidal hyperperfusion in patients with choroidal melanoma. The clinical usefulness of measuring POBF in tumour patients may be limited.

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Diagnosis and treatment control of choroidal melanomas ‐ the role of B‐scan and Doppler‐technique

Cited by 11 publications

References 5 publications

Experimental Differentiation of Intraocular Masses Using Ultrahigh-Field Magnetic Resonance Imaging – A Case Series

Experimental Differentiation of Intraocular Masses Using Ultrahigh-Field Magnetic Resonance Imaging – A Case Series

Investigation into the quantitative and qualitative characteristics of choroidal melanoma through magnetic resonance imaging and B-scan ultrasound

Choroidal perfusion in eyes with untreated choroidal melanoma

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