Diagnosis and Treatment Modalities of Symptomatic Polycystic Kidney Disease

Güler, Sanem; Çimen, Sertaç; Hurton, Scott; Molinari, Michele

doi:10.15586/codon.pkd.2015.ch4

Cited by 2 publications

(2 citation statements)

References 59 publications

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“…This suggests that the presence of the inflammatory cell infiltrate in the kidneys was induced by some pathogenic microorganism. Inflammatory cellular infiltrate has been detected in both hydronephrosis and porcine PDK [ 40 , 41 ], which is mainly induced by bacterial infections such as: E. coli and Actinobaculum suis [ 42 , 43 ]. E. coli strains can be classified as pathogenic or commensal and are an important indicator of fecal contamination in food and the food industry.…”

Section: Discussionmentioning

confidence: 99%

Detection of Cyclomodulin CNF-1 Toxin-Producing Strains of Escherichia coli in Pig Kidneys at a Slaughterhouse

Herrera-Vázquez,

Arellano-Aranda,

Hernández-Cueto

et al. 2023

Microorganisms

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Food is often contaminated with Escherichia coli (E. coli) bacteria strains, which have been associated with different diseases, including urinary tract infections. The consumption of meat by humans is a potential route of transmission of antimicrobial resistance, and food-producing animals have been associated as a major reservoir of resistant bacterial strains. The aim of this study was to determine the presence of the E. coli strains producing the CNF-1 toxin in pig kidneys. Pig kidneys were collected from a Mexican slaughterhouse and classified according to their coloration into reddish kidneys (RK) and yellowish kidneys (YK). A tissue sample from each kidney was processed for histological analysis, the presence of E. coli was determined by conventional PCR assay, and the CNF-1 toxin was detected by both conventional PCR and Western blotting. Herein, an inflammatory cell infiltrate was found in all collected kidneys, regardless of macroscopic differences. Surprisingly, E. coli and the CNF-1 toxin were detected in all kidney samples. We clearly demonstrate contamination by CNF-1 toxin-producing E. coli in pork kidneys from a slaughterhouse, even in those without apparent damage. This suggests that pork may serve as a reservoir for pathogens, representing an important risk to human health.

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Section: Discussionmentioning

confidence: 99%

Detection of Cyclomodulin CNF-1 Toxin-Producing Strains of Escherichia coli in Pig Kidneys at a Slaughterhouse

Herrera-Vázquez,

Arellano-Aranda,

Hernández-Cueto

et al. 2023

Microorganisms

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“…2 For patients with ADPKD who reach ESRD, kidney transplant is the preferred type of renal replacement therapy. 3 We aim to evaluate the demographics, outcomes, and complications of renal transplant in patients with ADPKD compared with other nephropathies.…”

Section: Introductionmentioning

confidence: 99%

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Barbouch

Hajji²,

Hedri³

et al. 2017

Exp Clin Transplant

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Objectives: Autosomal dominant polycystic kidney disease is a common cause of end-stage renal disease and a common indication for renal transplant. This study was undertaken to evaluate the demographics, outcomes, and complications of renal transplant in patients with autosomal dominant polycystic kidney disease compared with other nephropathies. Materials and Methods: In a retrospective case-control design, we reviewed the records of 7 patients with autosomal dominant polycystic kidney disease from a total of 701 renal transplant patients over a 30-year period (1986-2016). For each patient, a matched control was selected based on sex, age, year of transplant, and type of kidney donor. We excluded patients who underwent kidney transplant abroad and those with a follow-up period of less than 2 years. Results: The number of patients with autosomal dominant polycystic kidney disease requiring transplant at our center was estimated at 0.23 per year, and the condition represented 1.57% of initial nephropathy causes. The mean patient age at transplant was 50.8 ± 8.05 years. There were 5 male and 2 female patients in the case group, with a male-to-female ratio of 2.5. The source of the graft was predominantly a living related donor (5/7). Four patients had extrarenal manifestations, the most common of which were liver cysts (3 patients). Rejection occurred in a single study patient (14.2%) and in 4 control patients (57.1%; P = .51). Two patients did not develop any complications. Complications noted after transplant included infection (3/7 cases vs 2/7 controls; P = .67) and cerebrovascular accidents (2/7 cases vs 0/7 controls). Conclusions:Further studies with longer follow-up and greater numbers of patients are needed to compare more precisely the complications and results of transplant between patients with autosomal dominant polycystic kidney disease and other kidney transplant recipients.

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Diagnosis and Treatment Modalities of Symptomatic Polycystic Kidney Disease

Cited by 2 publications

References 59 publications

Detection of Cyclomodulin CNF-1 Toxin-Producing Strains of Escherichia coli in Pig Kidneys at a Slaughterhouse

Detection of Cyclomodulin CNF-1 Toxin-Producing Strains of Escherichia coli in Pig Kidneys at a Slaughterhouse

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