Diagnosis and treatment of acquired tracheomalacia in patients with cicatrical tracheal stenosis

Паршин, В Д; Koroleva, Irina; Mishchenko, Maria; Паршин, В В

doi:10.17116/hirurgia2016873-82

Cited by 6 publications

(1 citation statement)

References 46 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, there is no generally accepted adult classification of the causes of tracheomalacia. Tracheomalacia may result from tumor invasion [ 6 ], cicatricial tracheal stenosis associated with a tracheal tube [ 7 ], trauma and surgery [ 8 ], compression of an abnormal artery [ 9 , 10 ], or goiter [ 11 ], and can be associated with esophageal achalasia [ 12 ], cystic fibrosis [ 13 ], and chronic obstructive pulmonary disease [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Left Main Bronchus Stenosis Lesion, Neutrophil Count, and Platelet Count Are Predictors of Post-Tuberculosis Bronchomalacia

Bai

et al. 2021

Med Sci Monit

View full text Add to dashboard Cite

Background Post-tuberculosis bronchomalacia (PTBM) is one of the main conditions occurring in patients after tracheobronchial tuberculosis (TBTB), and is also associated with the recurrence of symptoms. The present study aimed to investigate the predictors of PTBM in patients who had been undergoing appropriate TB treatment. Material/Methods Clinical data of 104 patients with symptomatic airway stenosis after TBTB between January 01, 2019 and June 31, 2020 were recorded and analyzed. The association between baseline clinical characteristics, laboratory results, and PTBM was calculated with logistical regression. The time from onset of bronchoscopic intervention was examined by Kaplan-Meier estimates; differences between the 2 groups were tested by the log-rank test. Results Fifty-seven patients (54.81%) had PTBM. In the multivariate logistical analysis, the left main bronchus stenosis lesion (odds ratio [OR]=3.763), neutrophil (NEUT) count (OR=1.527), and platelet (PLT) (OR=1.010) count were predictors of PTBM. During follow-up, patients with BM had a significantly longer duration from onset of bronchoscopic intervention than patients without BM (hazard ratio=2.412, P <0.0001). Further, all patients needing long-term bronchoscopic intervention therapy were subsequently identified as having PTBM. Additionally, blood PLT counts were significantly decreased to normal levels in the non-BM group ( P <0.05), but not in the BM group ( P >0.05). Conclusions PTBM is most likely to occur in the left main bronchus. The inflammatory and immune responses associated with NEUT and PLT may represent therapeutic targets of PTBM. Our study is the first to report that decreased blood PLT count has the potential to monitor the treatment response.

show abstract

Section: Introductionmentioning

confidence: 99%

Left Main Bronchus Stenosis Lesion, Neutrophil Count, and Platelet Count Are Predictors of Post-Tuberculosis Bronchomalacia

Bai

et al. 2021

Med Sci Monit

View full text Add to dashboard Cite

show abstract

Circular tracheal resection for cicatrical stenosis and functioning tracheostomy

Паршин¹,

Титов²,

Паршин³

et al. 2017

Khir. Z. im. N.I. Pirogova

Self Cite

View full text Add to dashboard Cite

Re-tracheostomy within various terms after decanulation was performed in 68 (15.8%) patients. Tracheal resection with anastomosis was performed in 59 and 330 in both groups respectively. At present time these operations are performed more often in view of their standard fashion in everyday practice. In the second group tracheal resection followed by anastomosis was observed in 110 (25.6%) out of 430 patients with tracheostomy that is 4.4 times more often than in previous years. In total 2 patients died after 330 circular tracheal resections within 2001-2015 including one patient with and one patient without tracheostomy. Mortality was 0.6%. Moreover, this value was slightly higher in patients operated with a functioning tracheostomy compared with those without it - 0.9 vs. 0.5% respectively. The causes of death were bleeding into tracheobronchial lumen and pulmonary embolism. The source of bleeding after tracheal resection was innominate artery. Overall incidence of postoperative complications was 2 times higher in tracheostomy patients compared with those without it - 22 (20%) vs. 26 (11.8%) cases respectively. Convalescence may be achieved in 89.8% patients after circular tracheal resection. Adverse long-term results are associated with postoperative complications. So their prevention and treatment will improve the outcomes.

show abstract

Etiology, diagnosis and treatment of cicatricial tracheal stenosis

Starostin¹,

Berikkhanov²,

Паршин³

et al. 2020

Khir. Z. im. N.I. Pirogova

View full text Add to dashboard Cite

Diagnosis and treatment of acquired tracheomalacia in patients with cicatrical tracheal stenosis

Cited by 6 publications

References 46 publications

Left Main Bronchus Stenosis Lesion, Neutrophil Count, and Platelet Count Are Predictors of Post-Tuberculosis Bronchomalacia

Left Main Bronchus Stenosis Lesion, Neutrophil Count, and Platelet Count Are Predictors of Post-Tuberculosis Bronchomalacia

Circular tracheal resection for cicatrical stenosis and functioning tracheostomy

Etiology, diagnosis and treatment of cicatricial tracheal stenosis

Contact Info

Product

Resources

About