Diagnosis and Treatment of an Atypical Invasive Mole: A Case Report

Budiana, I Nyoman Gede; Pemayun, Tjokorda Gede Astawa

doi:10.13005/bpj/1945

Cited by 8 publications

(11 citation statements)

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“…Franke et al 17 and showed a sign of adnexal pathology which is in contrast to a study by Budiana and Pemayun. 18 Histopathologic examination of D&C sample showed villi and trophoblastic tissue which is similar to a study by Barber et al 19 In our study, patient was presented with vaginal bleeding with marked elevations in serum β-hCG levels which is complimentary to a study by Shaaban et al 20 Diagnosis include urine and blood levels of hCG (which are elevated during pregnancy) may give good indication, in most of the cases the levels are elevated, ultrasound (which shows a heterogeneous mass with no fetal development and theca-lutein ovarian cysts) and imaging tests (x-rays, magnetic fields, or radioactive substances) that help find out whether a tumor is present and to learn how far it may have spread. 2,3 Diagnosis is made based on measurement of serum β-hCG levels and USG findings as in a study conducted by Akhavan et al and Shaaban et al 20,21 In this case, GTD diagnosis as made primarily based on elevated serum β-hCG and pathologic examination confirmed our findings.…”

Section: Discussionmentioning

confidence: 99%

Persistent Invasive Mole: A Case Report

Kusuma¹,

Neela²,

Ramavath³

2021

IJOPP

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Gestational trophoblastic disease is a group of interrelated lesions arising from the trophoblastic epithelium of placenta after abnormal fertilization. It is a disease of women with pregnancy related tumors. Invasive mole, a common manifestation of gestational trophoblastic disease is characterized by villi accompanying trophoblastic overgrowths and invasion which penetrate deep into the myometrium sometimes involving peritoneum or vaginal vault. Here we present a case of persistent invasive mole in a patient who underwent dilation and curettage twice with persistent vaginal bleeding and elevated serum β-human Chorionic Gonadotropin levels. Investigations revealed enlarged uterus with adnexal pathology, Histopathological examination of Dilation and Curettage showed presence of villi and trophoblastic tissue, increased serum β-hCG levels. The patient is successfully treated and managed with methotrexate chemotherapy. This study is focused on the significance of follow-up of the patient as there are more chances of recurrence associated with gestational trophoblastic disease.

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Section: Discussionmentioning

confidence: 99%

Persistent Invasive Mole: A Case Report

Kusuma¹,

Neela²,

Ramavath³

2021

IJOPP

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“…Follow up serum β-HCG examination is done every 1-2 weeks until 3 consecutive normal values, then continued every 3 months for 6 months after normalization of serum β-HCG. 1 Invasive mole does not usually metastasize, and if it does, it is usually to lungs. 2 On the other hand, uterine vascular malformation, an abnormal connection between uterine arteries and veins, is a rare cause of uterine bleeding, sometimes torrential and life threatening.…”

Section: Discussionmentioning

confidence: 99%

“…Gestational trophobalstic neoplasia (GTN) is spectrum of trophoblastic diseases that includes invasive mole, placental site trophoblastic tumor (PSTT), epitheloid trophoblastic tumor (ETT) and choriocarcinoma. 1 Invasive mole constitutes 10-15% of complete hydatiform mole. It is characterized by edematous villi and overgrowth and invasion of trophoblast into myometrium, involving the peritoneum or vaginal vault.…”

Section: Introductionmentioning

confidence: 99%

Invasive mole diagnosed as vascular malformation of uterus: a case report

Bhattacharjee

Nath

Choudhury

2021

Int J Reprod Contracept Obstet Gynecol

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Gestational trophobalstic neoplasia encompasses invasive mole, placental site trophoblastic tumor, epitheloid trophoblastic tumor and choriocarcinoma. Here we report a 27 year old woman with invasive mole with severe anaemia who was initially misdiagnosed as a case of incomplete abortion with vascular malfomarmation of uterus. In view of uncontrolled bleeding per vaginum, nonspecific ultrasound findings and H/O failed dilatation and evacuation, exploratory laparotomy was decided upon and intraoperative finding was invasive mole. Hysterectomy was done.

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“…A high-resolution ultrasound is very useful in the assessment of myometrial invasion and molar residue after evacuation. [1] An invasive hydatiform mole is a form of gestational trophoblastic neoplasm that occurs due to abnormal proliferation of placental trophoblast. It is characterized by the presence of edematous chorionic villi with trophoblastic proliferation that invades into the myometrium of the uterus or to adjacent structures such as the vagina, vulva, broad ligament, and can also invade into the uterine vessels.…”

Section: Abstract Abstractmentioning

confidence: 99%

“…This terminology includes invasive mole, placental site trophoblastic tumor, and choriocarcinoma. [1] Invasive mole is a condition where a molar pregnancy, such as a partial hydatidiform mole or complete hydatidiform mole, invades the wall of the uterus, potentially spreading and metastasizing to other parts of the body (such as the vagina or lungs). [2] About 10-17% of hydatidiform moles exhibit invasive properties and 15% progress to distant metastasis.…”

Section: Introductionmentioning

confidence: 99%