Diagnosis and treatment of Candida vertebral osteomyelitis: Clinical experience with a short course therapy of amphotericin B lipid complex

Vertebral infection with Candida albicans failing caspofungin and fluconazole combination therapy but successfully treated with high dose liposomal amphotericin B and flucytosine

“…The additive fungicidal effect of 5-FC was neglectable when the amphotericin B dose was high. Furthermore, short course treatment with L-AMB has shown to be effective in a few cases [12], suggesting that this drug may be superior in bone infections. A combination of 5-FC and fluconazole successfully treated a case of Candida discitis [13].…”

Shoulder Joint Infectious Arthritis and Acromioclavicular Joint Osteomyelitis due to Candida

“…It was reported that in 15% of the patients with organ infection due to candida, the bone marrow was invaded 6. The most common pathogenic fungus is known to be Candida albicans, followed by Candida tropicalis, Candida parapsilosis, and Candida glabrata 6,7. However, Candida parapsilosis has rarely been detected as a pathogenic fungus of osteomyelitis and infectious arthritis as it was in this case report.…”

“…An estimated 80% of the patients had a history of abdominal surgery or parenteral-drug abuse 6. The patient in this case report had no history similar to that in previous cases except a history of regular acupuncture treatment for pain in the right shoulder joint that occurred a year ago.…”

“…Infections caused by candida can occur anywhere in the body. It was reported that in 15% of the patients with organ infection due to candida, the bone marrow was invaded 6. The most common pathogenic fungus is known to be Candida albicans, followed by Candida tropicalis, Candida parapsilosis, and Candida glabrata 6,7.…”

Development of a Real-Time Polymerase Chain Reaction Method for the Identification of Candida Species

“…Candida türleri ise, nozokomiyal enfeksiyonu olan hastaların kan kültürlerinden en sık izole edilen dördüncü etken olarak karşımıza çıkmaktadır [6][7][8] . Kan kültürlerinde en sık saptanan türün C.albicans olması-na karşın, albikans-dışı türler de giderek artan oranda izole edilmektedir 9 .…”