Diagnosis and treatment of definitive diverticular hemorrhage (DDH)

Jensen, Dennis M.

doi:10.1038/s41395-018-0061-4

Cited by 44 publications

(38 citation statements)

References 12 publications

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“…Mean CRLBs of glutamate in pons and thalamus were 7.9 and 4.8, while CRLBs were 27 and 21 for GABA in respective regions. For comparison, one 7T study reported CRLB of ∼2.5 for glutamate and ∼15 for GABA in cerebellum (Terpstra et al, 2016), another challenging area to measure with 1 H-MRS, while two other studies reported CRLB of ∼3 for glutamate and ∼7-29 for GABA in posterior cingulate cortex (van de Bank et al, 2015;Wijtenburg et al, 2019) and, by sLASER, ∼4 for glutamate in dorsal anterior cingulate cortex (Dempster et al, 2020). Compared to these less technically challenging 1 H-MRS regions, our CRLBs for pontine and thalamic glutamate and GABA investigations were wellestimated at 7T.…”

Section: Spectral Quality Assessmentmentioning

confidence: 99%

“…A limited number of studies investigating the variability of glutamate at 7T are available for comparison (Cai et al, 2012;Terpstra et al, 2016;Wijtenburg et al, 2019;Dempster et al, 2020). In addition, these studies apply larger MRS voxels with more cortical placement than in the current study.…”

Section: Glutamate and Gaba Estimationsmentioning

confidence: 99%

“…This study used PRESS with 100 acquisitions for the glutamate measurements (Cai et al, 2012). A more recent 7T study of anterior and posterior cingulate cortex reported CV of 6-8%, however, the results were reported as relative estimate to total creatine by STEAM and 96 acquisitions (Wijtenburg et al, 2019). Another 7T study reported within-subject glutamate variation of 20% measured in dorsal anterior cingulate cortex measured 1 month apart using sLASER with 32 acquisitions (Dempster et al, 2020).…”

Section: Glutamate and Gaba Estimationsmentioning

confidence: 99%

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Feasibility of Glutamate and GABA Detection in Pons and Thalamus at 3T and 7T by Proton Magnetic Resonance Spectroscopy

et al. 2020

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Glutamate detection in pons and thalamus using proton magnetic resonance spectroscopy (1 H-MRS) after an intervention is of interest for studying various brain disorders. However, 1 H-MRS in these brain regions is challenging and time-consuming, especially in longitudinal study designs. 1 H-MRS of more cortical structures at the ultrahigh magnetic field strength of 7T yields an improved spectral output, including separation of the glutamate signal from the glutamine signal, in a shorter and more feasible scan time, as compared to conventional clinical field strengths. For this purpose, we compared the feasibility of 1 H-MRS at 3T and 7T in pons and thalamus by applying a longitudinal study design of repeated measures on same day and three separate days at both field strength in five healthy participants. Total 1 H-MRS acquisition time was reduced by a factor 3.75 for pons and by a factor 3 for thalamus at 7T as compared to 3T. We found higher spectral signal-to-noise ratio (SNR) (p < 0.001), lower linewidth (p = 0.001) and lower Cramér-Rao lower bounds (CRLB) (p < 0.001) for the combined glutamate and glutamine signal (Glx) in thalamus at 7T as compared to 3T. In pons, CRLB of Glx and SNR were lower at 7T (p = 0.002 and p = 0.006), with no differences in linewidth compared to 3T. Mean within-subject variability of Glx concentration estimates was lower at 7T compared to 3T for both pons and thalamus. At 7T, it was possible to assess glutamate and γ-aminobutyric acid (GABA) simultaneously in pons and thalamus. In conclusion, 1 H-MRS at 7T resulted in improved spectral quality while allowing shorter scan times than at 3T as well as estimation of the pure glutamate signal in pons and thalamus. This opens up the opportunity for multimodal study designs and multiregional subcortical 1 H-MRS research. Glutamate and GABA measurement at 7T in pons and thalamus is advantageous for future investigations of excitatory-inhibitory mechanisms in brain disorders.

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Section: Spectral Quality Assessmentmentioning

confidence: 99%

Section: Glutamate and Gaba Estimationsmentioning

confidence: 99%

Section: Glutamate and Gaba Estimationsmentioning

confidence: 99%

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Feasibility of Glutamate and GABA Detection in Pons and Thalamus at 3T and 7T by Proton Magnetic Resonance Spectroscopy

et al. 2020

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“…Pulmonary disease is the leading cause of morbidity and mortality worldwide, with new threats emerging from vaping, rising air pollution, exposure from industrial farming, and worldwide pandemics, such as the infamous lung damaging coronavirus disease 2019 (Rattue, 2012;Guarascio et al, 2013;Nordgren and Bailey, 2016;Nordgren and Charavaryamath, 2018;Eskandari et al, 2019). COVID-19 has risen to be one of the biggest killers of 2020, which resulted in 5,817,385 confirmed cases and 362,705 deaths through May 30, 2020 (Stokes et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Introducing a Custom-Designed Volume-Pressure Machine for Novel Measurements of Whole Lung Organ Viscoelasticity and Direct Comparisons Between Positive- and Negative-Pressure Ventilation

Sattari

Mariano

Vittalbabu

et al. 2020

Front. Bioeng. Biotechnol.

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Asthma, emphysema, COVID-19 and other lung-impacting diseases cause the remodeling of tissue structural properties and can lead to changes in conducting pulmonary volume, viscoelasticity, and air flow distribution. Whole organ experimental inflation tests are commonly used to understand the impact of these modifications on lung mechanics. Here we introduce a novel, automated, custom-designed device for measuring the volume and pressure response of lungs, surpassing the capabilities of traditional machines and built to range size-scales to accommodate both murine and porcine tests. The software-controlled system is capable of constructing standardized continuous volume-pressure curves, while accounting for air compressibility, yielding consistent and reproducible measures while eliminating the need for pulmonary degassing. This device uses volume-control to enable viscoelastic whole lung macromechanical insights from rate dependencies and pressure-time curves. Moreover, the conceptual design of this device facilitates studies relating the phenomenon of diaphragm breathing and artificial ventilation induced by pushing air inside the lungs. System capabilities are demonstrated and validated via a comparative study between ex vivo murine lungs and elastic balloons, using various testing protocols. Volumepressure curve comparisons with previous pressure-controlled systems yield good agreement, confirming accuracy. This work expands the capabilities of current lung experiments, improving scientific investigations of healthy and diseased pulmonary biomechanics. Ultimately, the methodologies demonstrated in the manufacturing of this system enable future studies centered on investigating viscoelasticity as a potential biomarker and improvements to patient ventilators based on direct assessment and comparisons of positive-and negative-pressure mechanics.

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“…Similarly, disturbance of monocarboxylate transporter (e.g. MCT1 and MCT4) was shown to reduce RA severity [59,[66][67][68], as well as inhibition of tumour growth and CAFs recruitment in cancer [38,55,61,[69][70][71][72][73][74][75][76][77][78][79]. The use of Hexokinase 2 (HK2) inhibitors such as Lonidamine has also shown clinical success in RA [80], and in the cancer field [61,81].…”

Section: Metabolic Pathways As Therapeutic Targets In Rheumatoid Arthmentioning

confidence: 99%

Metabolic Reprogramming of Fibroblasts as Therapeutic Target in Rheumatoid Arthritis and Cancer: Deciphering Key Mechanisms using Computational Systems Biology Approaches

Aghakhani

Zerrouk

Niarakis³

2020

Preprint

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Fibroblasts, the most abundant cells in the connective tissue, are key modulators of the extracellular matrix (ECM) composition. These spindle-shaped cells are capable of synthesizing various extracellular matrix proteins and collagen. They also provide the structural framework (stroma) for tissues and play a pivotal role in the wound healing process. While they are maintainers of the ECM turnover and regulate several physiological processes, they can also undergo transformations responding to certain stimuli and display aggressive phenotypes that contribute to disease pathophysiology. In this review, we focus on the metabolic pathways of glucose and highlight metabolic reprogramming as a critical event that contributes to the transition of fibroblasts from quiescent to activated and aggressive cells. We also cover the emerging evidence that allows us to draw parallels between fibroblasts in autoimmune disorders and more specifically in rheumatoid arthritis and cancer. We link the metabolic changes of fibroblasts to the toxic environment created by the disease condition and discuss how targeting of metabolic reprogramming could be employed in the treatment of such diseases. Lastly, we discuss Systems Biology approaches, and more specifically, computational modelling, as a means to elucidate pathogenetic mechanisms and accelerate the identification of novel therapeutic targets.

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Diagnosis and treatment of definitive diverticular hemorrhage (DDH)

Cited by 44 publications

References 12 publications

Feasibility of Glutamate and GABA Detection in Pons and Thalamus at 3T and 7T by Proton Magnetic Resonance Spectroscopy

Feasibility of Glutamate and GABA Detection in Pons and Thalamus at 3T and 7T by Proton Magnetic Resonance Spectroscopy

Introducing a Custom-Designed Volume-Pressure Machine for Novel Measurements of Whole Lung Organ Viscoelasticity and Direct Comparisons Between Positive- and Negative-Pressure Ventilation

Metabolic Reprogramming of Fibroblasts as Therapeutic Target in Rheumatoid Arthritis and Cancer: Deciphering Key Mechanisms using Computational Systems Biology Approaches

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