2017
DOI: 10.5582/irdr.2016.01088
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Diagnosis and treatment of Dent disease in 10 Chinese boys

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Cited by 5 publications
(2 citation statements)
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“…As there are no standardized treatment protocols or guidelines for individuals with Dent’s disease, treatment is mainly supportive and focuses on managing hypercalciuria and preventing nephrolithiasis. 14 , 15 The rarity of the disease means that there have been no treatment trials conducted on a large group of patients. 8 - 12 End-stage renal disease occurs in 30-80% of affected males between the third and fifth decades of life.…”
Section: Discussionmentioning
confidence: 99%
“…As there are no standardized treatment protocols or guidelines for individuals with Dent’s disease, treatment is mainly supportive and focuses on managing hypercalciuria and preventing nephrolithiasis. 14 , 15 The rarity of the disease means that there have been no treatment trials conducted on a large group of patients. 8 - 12 End-stage renal disease occurs in 30-80% of affected males between the third and fifth decades of life.…”
Section: Discussionmentioning
confidence: 99%
“…Urine protein electrophoresis is an effective way for finding LMW proteinuria (17), which shows as excessive urinary loss of α1-microglobulin, β2-microglobulin, or other LMW plasma proteins. Zhang et al (18, 19) examined the ratio of urinary α1-microglobulin to microalbumin in 24 Chinese pediatric patients with renal tubular and interstitial diseases, suggesting that a ratio of urinary α1-microglobulin to microalbumin >1 could be used as a diagnostic criterion for tubuloproteinuria. In both our cases, the ratio of urinary α1-microglobulin to microalbumin tested multiple times were all >1, which may have some benefits for early diagnosis.…”
Section: Discussionmentioning
confidence: 99%