Diagnosis and treatment of diffuse large B-cell lymphoma

Mey, Ulrich; Hitz, Felicitas; Lohri, Andreas; Pederiva, Stefanie; Taverna, Christian; Tzankov, Alexandar; Meier, Oliver; Yeow, Karen; Renner, Christoph

doi:10.4414/smw.2012.13511

Cited by 26 publications

(29 citation statements)

References 115 publications

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“…Cytological reviews were possible in 14 of 22 BCL and 11 of 14 TCL cases, suggesting a predominance of DLBCL and peripheral TCL. This observation accords with both previous veterinary literature, in which these cytological classifications were the most commonly recognized among multicentric BCL and TCL cases [51], [55], [56], and reviews of human NHL [2], [57]. The similar cytological appearance of the most common types of canine and human BCL adds weight to the notion that the canine disease could model NHL [11].…”

Section: Discussionsupporting

confidence: 88%

Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma

et al. 2014

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The cancer microenvironment plays a pivotal role in oncogenesis, containing a number of regulatory cells that attenuate the anti-neoplastic immune response. While the negative prognostic impact of regulatory T cells (Tregs) in the context of most solid tissue tumors is well established, their role in lymphoid malignancies remains unclear. T cells expressing FOXP3 and Helios were documented in the fine needle aspirates of affected lymph nodes of dogs with spontaneous multicentric B cell lymphoma (BCL), proposed to be a model for human non-Hodgkin lymphoma. Multivariable analysis revealed that the frequency of lymph node FOXP3+ T cells was an independent negative prognostic factor, impacting both progression-free survival (hazard ratio 1.10; p = 0.01) and overall survival (hazard ratio 1.61; p = 0.01) when comparing dogs showing higher than the median FOXP3 expression with those showing the median value of FOXP3 expression or less. Taken together, these data suggest the existence of a population of Tregs operational in canine multicentric BCL that resembles thymic Tregs, which we speculate are co-opted by the tumor from the periphery. We suggest that canine multicentric BCL represents a robust large animal model of human diffuse large BCL, showing clinical, cytological and immunophenotypic similarities with the disease in man, allowing comparative studies of immunoregulatory mechanisms.

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Section: Discussionsupporting

confidence: 88%

Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma

et al. 2014

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“…Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma among adults, accounting for 25-50% of cases [1,2]. DLBCL is a heterogeneous disease, with multiple morphologic variants and histological subtypes [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…DLBCL is a heterogeneous disease, with multiple morphologic variants and histological subtypes [1][2][3]. We can distinguish, inter alia, nodal and primary extra nodal disease [1].…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of the number and type of extra nodal localizations of DLBCL in the rituximab era

Badora-Rybicka

Giebel

Studziński

et al. 2015

Acta Haematologica Polonica

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“…DLBCL probably arises via a stepwise process of somatic mutations, particularly chromosomal translocations involving oncogenes and, often, promoter regions of the immunoglobulin genes (10). …”

Section: Introductionmentioning

confidence: 99%

25 Years Old Women With Inflammatory Low Back Pain

Soltani

Davatchi

2016

Med Arh

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Introduction:Diffuse large B-cell lymphoma (DLBCL) is the most frequent histological type of malignant lymphomas (approximately 30% of cases). DLBCL is highly curable through chemotherapy. Rituximab in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy as the most frequent of care for first - DLBCL therapy, improves long-term survival of patients effectively.Case report:A young female (25 years old) complained about pain in her right back for two years. She was suffering from backache with priority in the right and contracture in mornings. Sacroiliac joint seemed normal but lytic and sclerotic lesions and also density changing of L5 and humerus head was revealed by CT scan. Biopsy was taken from the iliac bone and diffuse large B cell lymphoma was diagnosed.Conclusion:Chronic pains especially in axial skeleton, pelvis area and main joints must be taken seriously and examined by CT scan and MRI. If no particular issue was reported primarily while the pain was remained, a complete diagnosis BMB associated with PET must be applied. Despite of dependency on diagnosis the treatment by CHOP in association with rituximab is the most recommended chemotherapy alternative for patients with DLBCL.

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Diagnosis and treatment of diffuse large B-cell lymphoma

Cited by 26 publications

References 115 publications

Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma

Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma

Prognostic significance of the number and type of extra nodal localizations of DLBCL in the rituximab era

25 Years Old Women With Inflammatory Low Back Pain

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