Diagnosis and treatment of fetal and pediatric age patients (0–12 years) with Wolff–Parkinson–White syndrome and atrioventricular accessory pathways

Leoni, Loira; Bronzetti, Gabriele; Colonna, D; Porcedda, Giulio; Alessandro, Riccardo; Silvetti, Massimo Stefano

doi:10.2459/jcm.0000000000001484

Cited by 4 publications

(2 citation statements)

References 92 publications

(194 reference statements)

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“…Various other protein and receptor dysfunctions have been associated with not only the discontinuity of the annulus but also with the gap being bypassed by fast-conducting tissue (Bmp2, Alk3, TBX2, periostin) [29]. This hypothesis is strongly supported by the diagnosis of supraventricular tachycardias (SVT) in utero and by the greater prevalence of WPW syndrome in newborns and infants [30,31].…”

Section: Pathophysiologymentioning

confidence: 99%

“…In infancy, the diagnosis can be extremely challenging because of the nonspecific symptoms such as tachypnea, difficulty in feeding, irritability, abdominal pain, nausea, vomiting, and findings of heart failure if tachycardia continues for a long time [51]. It is important to acknowledge that AVRT can appear during fetal life (most often between 24 and 32 weeks), representing about 70% of arrhythmias during intrauterine life and being one of the most important causes of heart failure with fetal hydrops [29]. Diagnosis is typically made following an episode of atrioventricular reciprocating tachycardia.…”

Section: Diagnosismentioning

confidence: 99%

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Wolf–Parkinson–White Syndrome: Diagnosis, Risk Assessment, and Therapy—An Update

Vătășescu,

Paja,

Șuș

et al. 2024

Diagnostics

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Wolf–Parkinson–White (WPW) syndrome is a disorder characterized by the presence of at least one accessory pathway (AP) that can predispose people to atrial/ventricular tachyarrhythmias and even sudden cardiac death. It is the second most common cause of paroxysmal supraventricular tachycardia in most parts of the world, affecting about 0.1–0.3% of the general population. Most patients with WPW syndrome have normal anatomy, but it may be associated with concomitant congenital heart disease or systemic diseases. Although many individuals are asymptomatic, during supraventricular arrhythmia episodes, they may experience severe symptoms, including syncope or even sudden cardiac death (mainly due to pre-excited atrial fibrillation over rapidly conducting AP). In addition to arrhythmia-related symptoms, for some specific locations of the APs with overt anterograde conduction, there might be a reduction in exercise capacity mediated by a reduction in LV systolic performance due to anomalous LV depolarization. Although it is typically diagnosed through electrocardiography (ECG), additional tests are necessary for risk assessment. Management of WPW syndrome may be quite challenging and can vary from only acknowledging the presence of the accessory pathway to pharmacological treatment or radiofrequency ablation. Early diagnosis, risk assessment, and appropriate treatment are critical steps in the management of WPW syndrome, aiming to improve the quality of life and reduce the risk of life-threatening arrhythmias.

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Section: Pathophysiologymentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Wolf–Parkinson–White Syndrome: Diagnosis, Risk Assessment, and Therapy—An Update

Vătășescu,

Paja,

Șuș

et al. 2024

Diagnostics

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Antiarrhythmic therapy for narrow QRS supraventricular tachyarrhythmias in newborns and infants in the first year of life: Potent tools to be handled with care

Ciriello,

Sorice,

Orlando

et al. 2024

Indian Pacing and Electrophysiology Journal

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Wolff-Parkinson-White Syndrome in the Preterm Neonate

Jadczak,

Jnah

2024

Neonatal Network

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Wolff-Parkinson-White (WPW) syndrome is a rare cardiac condition arising from abnormal embryologic development of the annulus fibrosus in combination with the cardiac conduction system. The abnormality results in the development of accessory pathways and preexcitation changes which can provoke episodes of tachyarrhythmias. The most common presentation of WPW syndrome is supraventricular tachycardia. Beyond customary abortive therapy, chronic management strategies vary based upon timing and clinical severity of the initial disease presentation. Prompt diagnosis and rate control have a dramatic impact on the outcomes of morbidity and mortality. The purpose of this article is to present a case study of a preterm infant who manifested with WPW syndrome. Additionally, the article will explore the pathophysiology of WPW syndrome and the timing and presentation of common clinical manifestations of the disease, along with current diagnostic and treatment strategies to achieve optimal patient outcomes in the neonatal population.

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Diagnosis and treatment of fetal and pediatric age patients (0–12 years) with Wolff–Parkinson–White syndrome and atrioventricular accessory pathways

Cited by 4 publications

References 92 publications

Wolf–Parkinson–White Syndrome: Diagnosis, Risk Assessment, and Therapy—An Update

Wolf–Parkinson–White Syndrome: Diagnosis, Risk Assessment, and Therapy—An Update

Antiarrhythmic therapy for narrow QRS supraventricular tachyarrhythmias in newborns and infants in the first year of life: Potent tools to be handled with care

Wolff-Parkinson-White Syndrome in the Preterm Neonate

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