Diagnosis and Treatment of Galactosaemia

Hudson, F. P.; Ireland, J. T.; Ockenden, B. G.; White-Jones, R H

doi:10.1136/bmj.1.4856.242

Cited by 20 publications

(10 citation statements)

References 3 publications

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“…It is possible that the condition of galactosaemia, of which there are recent accounts by Bray, Isaac & Watkins (1952), Hudson, Ireland, Ockenden & White-Jones (1954) and Fox, Fyfe & Mollison (1954) may also be due to this action of galactose.…”

Section: R B Fisher and D B Lindsaymentioning

confidence: 99%

The action of insulin on the penetration of sugars into the perfused heart*

Fisher¹,

Lindsay²

1956

The Journal of Physiology

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Section: R B Fisher and D B Lindsaymentioning

confidence: 99%

The action of insulin on the penetration of sugars into the perfused heart*

Fisher¹,

Lindsay²

1956

The Journal of Physiology

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“…It is now almost a routine procedure for the urine of a baby becoming ill with jaundice in the first few days of life and not thriving to be tested for reducing substances. Hudson and Ireland (1954) have, however, warned against reaching a hasty diagnosis of galactosaemia if galactose is found in the urine of such a baby.There is little information in the literature about the physiological excretion of reducing sugars by newborn babies. Woolf (1951) said that small amounts of galactose and lactose are found in the urines of milk-fed infants, but he gave no figures.…”

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confidence: 99%

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“…In particular it has provided an accurate and comparatively easy method of separating reducing sugars in the urine. This has proved of great value in the investigation of such a condition as congenital galactosaemia, about which disease there has been much recent interest (Bray, Isaac and Watkins, 1952;Hudson, Ireland, Ockenden and White-Jones, 1954;Cox and Pugh, 1954). It is now almost a routine procedure for the urine of a baby becoming ill with jaundice in the first few days of life and not thriving to be tested for reducing substances.…”

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confidence: 99%

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Chromatographic Separation of Reducing Sugars in the Urines of Newborn Babies

Haworth¹,

McCredie²

1956

Archives of Disease in Childhood

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The application of paper chromatography to the qualitative analysis of reducing sugars by Partridge (1946) has greatly simplified the detection of these substances in biological fluids. In particular it has provided an accurate and comparatively easy method of separating reducing sugars in the urine. This has proved of great value in the investigation of such a condition as congenital galactosaemia, about which disease there has been much recent interest (Bray, Isaac and Watkins, 1952;Hudson, Ireland, Ockenden and White-Jones, 1954;Cox and Pugh, 1954). It is now almost a routine procedure for the urine of a baby becoming ill with jaundice in the first few days of life and not thriving to be tested for reducing substances. Hudson and Ireland (1954) have, however, warned against reaching a hasty diagnosis of galactosaemia if galactose is found in the urine of such a baby.There is little information in the literature about the physiological excretion of reducing sugars by newborn babies. Woolf (1951) said that small amounts of galactose and lactose are found in the urines of milk-fed infants, but he gave no figures. He also said that xylose is frequently present in normal urines, but rarely exceeds 3 mg./100 ml. Rubin (1954) stated that sugars may be found in small amounts in the urines of healthy infants in the early months of life, but he gave no details. Flynn, Harper and de Mayo (1953) found lactose in the unnes of 900 of normal men and women. This paper is a report of our findings of the examination by paper chromatogaphy of the urines of 50 normal male babies. Results Eighty-one urines were collected from the 50 babies.Twenty-two babies (from whom 34 urines were collected) showed no reducing sugar in any specimen. Four babies (five urines) showed an unidentified reducing substance only. Twenty-four babies (42 urines) showed one or more reducing sugar in 25 specimens.

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“…The clinical syndrome of galactosaemia is now well known and more than 40 cases have been carefully described in the literature (Bell, Lindsay and Watson, 1950;Bray, Isaac and Watkins, -1952;Donnell and Lann, 1951;Darling and Mortensen, 1954; Goldbloom and Brickman, 1946;Goldstein and Ennis, 1948;Goppert, 1917;Greenman and Rathbun, 1948;Hudson, Ireland, Ockenden and White-Jones, 1954;Johns, 1953;Maris and Valcke, 1953;Mason and Turner, 1935;Mellinkoff, Roth and MacLaggan, 1945;Mortensen and S0ndergaard, 1954;Norman and Fashena, 1943;Reiter and Lasky, 1952;Townsend, Mason andStrong, 1951 Unshelm, 1934).…”

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confidence: 99%