Diagnosis and treatment of granulomatous mastitis

Salam, Md. Abdus; Al-Homsi, M.; Daniel, Mina; Sim, A. J. W.

doi:10.1002/bjs.1800820227

Cited by 41 publications

(40 citation statements)

References 4 publications

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“…Indeed, some patients had been exposed to mastectomy following an incorrect diagnose of malignancy as a result of false positive FNAB (7,21). Generally single breast involvement is seen, although bilateral breast involvement has been reported, and all four quadrants can be affected (4,7,8,21,22). In our study, single breast involvement was identified in all cases.…”

Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 45%

“…One third of the patients with granulomatous mastitis have a history of oral contraceptive use in some publications (7). Two (17%) of our cases were on oral contraceptives at the time of diagnosis (4,8,22,(25)(26)(27). The infectious agents were implicated in the etiology of GLM, but they have not been isolated and proven so far (9).…”

Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 78%

“…Autoimmunity was generally held responsible for the etiology. Leakage of intraluminal fluids into the lobular connective tissue as a result of damage in the ductal epithelium following local trauma, local chemical irritation or infection were thought to trigger granulomatous response by lymphocyte and macrophage migration (7,22). However, serologic tests such as Anti Nuclear Antibody (ANA) and Rheumatoid Factor (RF), which demonstrate the presence of autoimmunity, are generally negative.…”

Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 99%

“…While being unilateral in general, rare cases of bilateral involvement have been reported (8,21,22). The location and dimensions, and the volume of the breast are important in unilateral cases.…”

Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 99%

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A Challenging Entity in the Differential Diagnosis of Breast Cancer: A Retrospective Analysis of 17 Cases With Granulomatous Lobular Mastitis

Eser¹,

Kaptanoğlu²,

Kement³

et al. 2013

J Breasth Health

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Results: All the cases were women of childbearing age, who had given birth and breastfed at least once. The most common causes for admission were; breast mass in 12 patients (70.6%) and pain in 12 (70.6%) cases. Five (29.4%) cases developed a fistula and four (23.5%) had abscess requiring drainage. Mammography was used for 10 (58.8%) cases, 12 (70.6%) were examined by MRI and all the patients were evaluated with ultrasound. Five (29.4%) cases were suspicious for malignancy prior to biopsies. Diagnoses of sixteen (94.1%) cases were established with tru-cut biopsy. Fourteen (82.3%) cases underwent wide local excision (WLE) following antibiotic therapy and/or drainage and 3 (17.6%) cases with diffuse disease also underwent wide local excision following therapy with antibiotics and/or drainage and steroids (prednisolone 32 mg bid). Complete remission was observed in one patient with diffuse disease who was referred to our clinic with excisional biopsy after steroid therapy (prednisolone 32 mg bid). Relapse developed in two (11.7%) cases in the end of thirty-six months of median follow-up. Both patients were treated with steroids (prednisolone 32 mg bid). Sonuç: GLM zor tanı konulabilen ve yaygın kabul görmüş bir tedavisi olmayan selim bir meme hastalığıdır. Geniş local eksizyon uygun olgularda tek başına, yaygın tutulumu olan olgularda ise steroid tedavisi sonrası başarı ile uygulanabilir. Conclusion

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Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 45%

Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 78%

Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 99%

Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 99%

See 2 more Smart Citations

A Challenging Entity in the Differential Diagnosis of Breast Cancer: A Retrospective Analysis of 17 Cases With Granulomatous Lobular Mastitis

Eser¹,

Kaptanoğlu²,

Kement³

et al. 2013

J Breasth Health

View full text Add to dashboard Cite

show abstract

“…15 The treatment plan for IGM followed at most centres is to perform a complete resection or an open biopsy with corticosteroid therapy. 16 However, surgery can be complicated by abscess formation, fistulas, scarring and chronic suppuration. Chronic mastitis after excisional biopsies has also been reported.…”

mentioning

confidence: 99%

Idiopathic Granulomatous Mastitis : Diagnostic Strategy and Therapeutic Implications in Omani Patients = إلتهاب الثدي الحبيبي : خطط التشخيص و التطبيقات العلاجية للمرضى العمانيين

Aljarrah¹,

Taranikanti²,

Lakhtakia³

et al. 2013

SQUMJ

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abstract:Objectives: Idiopathic granulomatous mastitis (IGM) is a rare benign disorder of the breast whose aetiology is controversial, and is often misdiagnosed clinically and radiologically as mammary malignancy; as a result, it may be incorrectly treated. Although no standard treatment is available for this chronic disease, surgery with or without corticosteroids has been tried with controversial results. This study discusses the clinical presentation, diagnosis, management, recurrence, and follow-up data of IGM with a review of relevant literature. Methods: From 2009-2012, the Breast Unit at Sultan Qaboos University Hospital, Oman, conducted a clinical study on 20 patients with breast lumps. Their clinical and radiological examinations were indeterminate, and a diagnosis of granulomatous mastitis was established only by histopathology. Results: The majority of the patients were cases of unknown aetiology, who presented with a unilateral breast mass. A few patients had a mass with an abscess, along with axillary lymphadenopathy. A total of 4 patients were suspected of malignancy using radiology. In all patients, sterilised pus was sent for culture and sensitivity. Microscopy showed the characteristic pattern of granulomatous inflammation. All patients were treated with antibiotics for 6 weeks, and the mean follow-up period was 15 months (11-33 months). All patients had complete remission with no further recurrence. Conclusion: This single largest study of cases of IGM in Oman highlights the pitfalls in diagnosing this non-neoplastic disease of unknown aetiology and uncertain pathogenesis. It emphasises IGM's excellent response to antibiotics, which is crucial, as IGM is a disease which is notoriously difficult and controversial to treat.

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Granulomatous mastitis: Gray-scale and color Doppler sonographic findings

Engin

Acunaş

1999

J. Clin. Ultrasound

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Diagnosis and treatment of granulomatous mastitis

Cited by 41 publications

References 4 publications

A Challenging Entity in the Differential Diagnosis of Breast Cancer: A Retrospective Analysis of 17 Cases With Granulomatous Lobular Mastitis

A Challenging Entity in the Differential Diagnosis of Breast Cancer: A Retrospective Analysis of 17 Cases With Granulomatous Lobular Mastitis

Idiopathic Granulomatous Mastitis : Diagnostic Strategy and Therapeutic Implications in Omani Patients = إلتهاب الثدي الحبيبي : خطط التشخيص و التطبيقات العلاجية للمرضى العمانيين

Granulomatous mastitis: Gray-scale and color Doppler sonographic findings

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