Diagnosis and Treatment of Metronidazole-Resistant Trichomonas vaginalis Infection

Smith, Jeffrey; Cudmore, Sarah L.; Garber, Gary

doi:10.1007/978-3-319-47266-9_28

Cited by 3 publications

(1 citation statement)

References 156 publications

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“…However, side effects such as nausea, vomiting, bad taste, gastrointestinal disorders, exanthem, urticaria, angioedema, vertigo, peripheral neuropathy, and transient neutropenia are observed with the use of this drug, which reduces the willingness to use it by the patients (10)(11)(12). Additionally, in recent years, the evidence of drug resistance to metronidazole has been reported in some studies, which could be another reason for research on alternative trichomoniasis treatment (13).…”

Section: Introductionmentioning

confidence: 99%

Anti-Trichomonas vaginalis Effect of Methanolic Extracts of Sambucus nigra in Comparison with Metronidazole

Niknam

Esboei

Chabra

2020

Jundishapur J Nat Pharm Prod

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Background: Trichomoniasis is the most common non-viral sexually transmitted disease caused by a flagellated protozoan living in the genitourinary tract, which infects both men and women. Metronidazole is the treatment of choice for trichomoniasis. Researchers are seeking an alternative to metronidazole because of its inevitable side effects and toxicity. Objectives: This study aimed to evaluate the effect of the methanolic extract of Sambucus nigra against Trichomonas vaginalis in vitro. Methods: Plants were collected from different areas of Mazandaran Province, northern Iran. Fruits were separated, shade-dried, milled, and their methanolic extract was prepared in concentrations of 100, 200, 400, and 800 µg/mL. Parasites were obtained from patients referring to different health centers of Mazandaran province, cultured in Dorset medium, and incubated at 37°C. The effects were evaluated and compared to a control group. The data were analyzed by SPSS 18 using the ANOVA test. Results: The exposure time and concentration of the extracts had a direct effect on anti-parasitic activity so that increasing extract concentration and incubation time heightened the anti-trichomoniasis effects. The concentrations of 400 and 800 µg/ml of the plant had 100% efficacy after 72 and 48 hours, respectively. Conclusions: It can be concluded from our results that the methanolic extract of S. nigra has a remarkable ability to destroy T. vaginalis and it can be considered an effective drug against T. vaginalis with further studies in human and animal models.

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Section: Introductionmentioning

confidence: 99%

Anti-Trichomonas vaginalis Effect of Methanolic Extracts of Sambucus nigra in Comparison with Metronidazole

Niknam

Esboei

Chabra

2020

Jundishapur J Nat Pharm Prod

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Mechanisms of Resistance to Antiparasitic Agents

Bradbury,

Talundzic

2023

ClinMicroNow

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Parasitic diseases rank among the most prevalent and severe diseases worldwide. The danger of depending on drugs as one of the primary tools for control is compounded by the relatively limited number of antiparasitic agents available. The complex biologic interactions between parasites and their hosts (and, at times, their vectors) significantly influence the emergence and expression of drug resistance. The development of resistance to all antimalarial drugs poses the greatest challenge for malaria control and prevention globally. Praziquantel is the only drug currently being used for treatment of schistosomiasis. The widespread use of albendazole, mebendazole, levamisole, and pyrantel in preventive chemotherapy programs to control soil‐transmitted helminth infections has raised concerns regarding the potential for the development of resistance in this group of intestinal nematodes. Public health interventions to correct these factors have not always been successful and would benefit from a better understanding of the drug resistance mechanisms used by parasites.

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Lack of association between Mycoplasma hominis and Trichomonas vaginalis symbiosis in relation to metronidazole resistance

2020

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Diagnosis and Treatment of Metronidazole-Resistant Trichomonas vaginalis Infection

Cited by 3 publications

References 156 publications

Anti-Trichomonas vaginalis Effect of Methanolic Extracts of Sambucus nigra in Comparison with Metronidazole

Anti-Trichomonas vaginalis Effect of Methanolic Extracts of Sambucus nigra in Comparison with Metronidazole

Mechanisms of Resistance to Antiparasitic Agents

Lack of association between Mycoplasma hominis and Trichomonas vaginalis symbiosis in relation to metronidazole resistance

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