Diagnosis and treatment of trigeminal neuralgia: Consensus statement from the Spanish Society of Neurology’s Headache Study Group

Latorre, G.; González‐García, Nuria; García-Ull, Jésica; González-Oria, C.; Porta‐Etessam, J.; Molina, Francisco; Ál, Guerrero-Peral; Belvís, R.; Rodríguez, R.; Bescós, Agustín; Irimia, P.; Santos-Lasaosa, S

doi:10.1016/j.nrleng.2023.04.005

Cited by 6 publications

(3 citation statements)

References 72 publications

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“…The pain is so clearly described that most of the time the diagnosis can be established based on a simple history. With the intraoral area as a triggering area, some patients may confuse it with dental pain [49,50].…”

Section: Physiology Of Oral Cavity Pathologymentioning

confidence: 99%

Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity

Cocoș,

Dumitriu Buzia,

Tatu

et al. 2024

Pharmaceutics

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In this study, we focused on innovative approaches to improve drug administration in oral pathology, especially by transmucosal and transdermal pathways. These improvements refer to the type of microneedles used (proposing needles in the saw), to the use of certain enhancers such as essential oils (which, besides the amplifier action, also have intrinsic actions on oral health), to associations of active substances with synergistic action, as well as the use of copolymeric membranes, cemented directly on the tooth. We also propose a review of the principles of release at the level of the oral mucosa and of the main release systems used in oral pathology. Controlled failure systems applicable in oral pathology include the following: fast dissolving films, mucoadhesive tablets, hydrogels, intraoral mucoadhesive films, composite wafers, and smart drugs. The novelty elements brought by this paper refer to the possibilities of optimizing the localized drug delivery system in osteoarthritis of the temporomandibular joint, neuropathic pain, oral cancer, periodontitis, and pericoronitis, as well as in maintaining oral health. We would like to mention the possibility of incorporating natural products into the controlled failure systems used in oral pathology, paying special attention to essential oils.

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Section: Physiology Of Oral Cavity Pathologymentioning

confidence: 99%

Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity

Cocoș,

Dumitriu Buzia,

Tatu

et al. 2024

Pharmaceutics

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“…The pain is often described as “sharp, stabbing or electric shock-like” and the characteristic feature is the “brief pain attacks.” The increased cases of misdiagnoses are seen despite the availability of diagnostic criteria with proper definitions. The pain is often confused with odontogenic pain and results in unnecessary extractions and other dental treatments [ 2 ]. The individuals affected are primarily above 50 years with a prevalence of 12 to 30 cases per 1,00,000 people, where women are more frequently affected (60%) than men [ 1 , 2 ] with a ratio of 3:5 .…”

Section: Introductionmentioning

confidence: 99%

“…The pain is often confused with odontogenic pain and results in unnecessary extractions and other dental treatments [ 2 ]. The individuals affected are primarily above 50 years with a prevalence of 12 to 30 cases per 1,00,000 people, where women are more frequently affected (60%) than men [ 1 , 2 ] with a ratio of 3:5 . The symptoms are usually described as sudden shooting or stabbing pain, which may be solitary sensations or paroxysms in between pain‐free intervals, which are usually triggered by nonpainful stimuli such as exposure to a gentle breeze, facial touch, brushing the teeth, or chewing food [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Trigeminal Neuralgia Due to Neurovascular Conflict: A Case Report

Shinde,

Lohe,

Mohod

et al. 2024

Cureus

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A 47-year-old female patient visited the outpatient department with the complaint of “sharp shooting, radiating type of pain” on the maxillary left posterior gingiva for the last three months. The patient was advised a magnetic resonance imaging (MRI) scan which gave the radiological diagnosis of trigeminal neuralgia (TN). It also stated that the root entry zone of cranial nerve-V (CN-V) was in contact with the superior cerebellar artery and anterior inferior cerebellar artery. The patient was kept on a carbamazepine and gabapentin combination and a supportive therapy of multivitamins which brought complete remission within 1.5 months. This case report supports the combination therapy of carbamazepine and gabapentin with supportive therapy of multivitamins.

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Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2 × 2 factorial trial

Li,

Sun,

Luo

et al. 2024

J Neurol

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Background Trigeminal neuralgia (TN) is difficult to treat due to its severe pain intensity and recurring episodes, which significantly impact quality of life. Objectives We aimed to assess the effectiveness of electroacupuncture (EA) in alleviating the pain intensity in TN, and to determine whether EA combined with low-dosage carbamazepine (CBZ) has a synergistic effect. Methods A multi-centre, randomized, 2 × 2 factorial trial was conducted. Participants who met the inclusion criteria received active EA or sham EA for 60 min, three times a week for four weeks; CBZ (300 mg per day) or placebo for four weeks. The primary outcome was the change in visual analog scale (VAS) score from baseline to weeks 2, 4, 16, and 28. Secondary outcomes included quality of life and adverse events. Results A total of 120 participants (75 females and 45 males; mean (SD) age, 58.5 (15.3) years) were included. The main effects of EA and CBZ were significant (P < 0.001), and there was a significant interaction was identified between the interventions (P = 0.041). Participants who received EA (mean difference [MD], −0.3 [95% CI, −0.40 to −0.20] at week 2; −1.6 [−1.70 to −1.50] at week 4; −1.1 [−1.31 to −0.89] at week 16; −0.8 [−1.01 to −0.59] at week 28), CBZ (MD, −0.6 [95% CI, −0.70 to −0.50] at week 2; −0.9 [−1.03 to −0.77] at week 4, −0.2 [−0.41 to 0.01] at week 16, 0.2 [−0.01 to 0.41] at week 28), and the combination of both (MD, −1.8 [95% CI, −1.90 to −1.70] at week 2; −3.7 [−3.83 to −3.57] at week 4, −3.4 [−3.61 to −3.19] at week 16, −2.9 [−3.11 to −2.69] at week 28) had a greater reduction in VAS score over the treatment phase than their respective control groups (sham EA, placebo, and sham EA plus placebo). EA-related adverse events (6/59, 10.17%) were lower than that of CBZ (15/59, 25.42%) during the whole phases. Conclusions EA or CBZ alone are effective treatments for TN, while the combination of EA and low-dosage CBZ exerts a greater benefit. These findings in this trial demonstrate that the combination of EA and low-dosage CBZ may be clinically effective under certain circumstances. Trial registration NCT03580317.

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Diagnosis and treatment of trigeminal neuralgia: Consensus statement from the Spanish Society of Neurology’s Headache Study Group

Cited by 6 publications

References 72 publications

Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity

Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity

Trigeminal Neuralgia Due to Neurovascular Conflict: A Case Report

Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2 × 2 factorial trial

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