Background High triglycerides may lead to other conditions such as hypothyroidism or liver and kidney disease. Certain medications, such as beta-blockers, birth control pills and steroids, can increase triglyceride levels. Other factors can affect triglyceride levels Methodology Biochemical tests included (serum cholesterol, triglyceride, LDL, RBS and HbA1c These tests were performed according to the working method of each analysis on the device Full automate and TUSO Hematological test included( WBC count RBC count Hb and PCV) These tests were conducted at CBC device .Result illustrates a study of some biochemical variables for people with lipoma and comparing them with healthy peoples , where mean of the affected persons for cholesterol and triglyceride tests was 312, 296, respectively, compared with the control 116, 89, respectively, and the level of sugar and HbA1c in the affected persons was 11, 226 on Respectively compared to control 86, 3, respectively, and this explains that there is a direct relationship between the rise in fat and blood sugar with the emergence of lipoma Conclusion We conclude that the most vulnerable people are those who suffer from high levels of triglycerides and cholesterol, as well as those with high blood sugar, as well as the genetic factor that plays a major role in causing this disease, as the genetic factor gave a large percentage of infection with this disease, as well as the quality of nutrition has a great role