Diagnosis and treatment options of vulvar cancer: a review

Dittmer, C.; Fischer, Dorothea; Diedrich, K.; Thill, Marc

doi:10.1007/s00404-011-2057-9

Cited by 31 publications

(28 citation statements)

References 64 publications

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“…Even if most of affected women complain several symptoms, including vulvar pruritus, pain and irritation, up to 50 % are asymptomatic at the time of the diagnosis. The lesion may also occur as an endophytic ulcer or an exophytic or papillomatous mass [8]. 95 % of malignant tumours of vulva are squamous-cell carcinoma, also histologically divided in three groups: warty, basaloid, and keratinizing.…”

Section: Discussionmentioning

confidence: 99%

“…In fact these factors are independent prognosis factors and clinical status of inguinal lymph nodes is the most important prognostic factor in overall survival [2,8]. Surgery is first choice therapy of for locoregional VC.…”

Section: Discussionmentioning

confidence: 99%

“…However, the severe morbidity of this mutilating procedure as well as the consecutive psychosexual impairment was a very high price for the treatment [5], as well as impaired wound healing in about 40 % and seroma due to the large subcutaneous resection [8].…”

Section: En Bloc Surgerymentioning

confidence: 99%

“…An approach to reduce morbidity with a more conservative surgery while preserving adequate local control was made by Byron who first introduced the triple incision technique [5]: it includes a complete excision of the tumour by vulvectomy or radical local excision and removal of the lymph nodes by two separate inguinal incisions without the complementary removal of skin [8].…”

Section: Triple Incision Techniquementioning

confidence: 99%

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Recent trends in surgical and reconstructive management of vulvar cancer: review of literature

et al. 2015

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Vulvar cancer (VC) is a rare disease. The most common histologic type is squamous-cell carcinoma. VC could be divided into two types: type one, commonly associated with HPV infection, occurs in young women and type two, associated with non-neoplastic lesions that usually occurs in older women. Previously VC was often treated with radical Vulvectomy. Today update in diagnostic and surgery technique, capable to identify early stages of disease and adaptation in surgery procedures, according to the stage of disease, age of patients and possible physical and psychological morbidity consequence, allow using less radical surgery approaches. That has led to decrease therapy-associated morbidity while preserving oncologic safety and improving psychosexual outcomes. Finally, several surgical treatments are available in case of VC and, despite radical surgery is often required, less radical surgery associated with reconstructive plastic surgery decreases some of short- and long-term associated complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: En Bloc Surgerymentioning

confidence: 99%

Section: Triple Incision Techniquementioning

confidence: 99%

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Recent trends in surgical and reconstructive management of vulvar cancer: review of literature

et al. 2015

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“…Considering the significant morbidity of radical lymphadenectomy and the fact that only 25-30% of the patients present with lymph node metastases at first diagnosis, sentinel node dissection is considered a favorable alternative for patients with a clinically node-negative inguinal area (11). Patients with early-stage disease have a fairly good prognosis with an individualized treatment plan and a less radical surgical approach (12). Local tumor resection rather than radical vulvectomy and the implementation of the sentinel technique have decreased therapy-associated morbidity and psychosocial impairment in these patients, while maintaining oncological safety (11).…”

Section: Discussionmentioning

confidence: 99%

Primary mucinous adenocarcinoma of the vulva: A case report and review of the literature

Sui

Zou

Batchu

et al. 2016

Molecular and Clinical Oncology

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Abstract. Primary vulvar cancer is a rare disease with an incidence of 2-3 per 100,000 women. The vast majority of vulvar carcinomas are of the squamous cell type (90%). Primary vulvar adenocarcinomas rank among the rare gynecological malignancies. We herein present a case of a vulvar mass near the vaginal orifice, the biopsy of which revealed a mucinous adenocarcinoma. Local excision was performed, followed by postoperative chemotherapy. The patient was asymptomatic and developed no recurrence during the 2 years of follow-up after surgery and chemotherapy. We consider local excision, with or without chemotherapy, to be an effective therapeutic approach to this type of tumor. However, further studies are required to support our conclusions for early-stage vulvar mucinous adenocarcinoma.

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Development and validation of nomograms predicting cancer‐specific survival of vulvar cancer patients: based on the Surveillance, Epidemiology, and End Results Program

Liu

Wang

2021

Intl J Gynecology & Obste

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Objective: To explore potential prognostic factors and develop nomograms to predict the cancer-specific survival of patients with vulvar squamous cell carcinoma (SCC) and patients with vulvar melanoma. Methods: Cases of vulvar SCC and melanoma were retrieved from the Surveillance, Epidemiology, and End Results (SEER) Program, and randomly segregated into training and test sets. Based on the training set, univariate and multivariate Cox proportional hazard regressions evaluate the association between key demographic/clinical characteristics and vulvar cancer survival. Potential prognostic factors were included to construct nomograms for the prediction of 3-year and 5-year survival probabilities. Results: Age, tumor size, stage, surgery, and chemotherapy were potential factors associated with vulvar cancer survival. The C-indices for the training and test sets were 0.82 and 0.81 for SCC, and 0.73 and 0.70 for melanoma. Calibration curves revealed correlated agreements between nomogram-based probability and actual survival status. Conclusion:Nomograms were developed to predict cancer-specific survival of patients with vulvar cancer, accordingly identifying the subgroup at high risk of cancerspecific mortality.

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Diagnosis and treatment options of vulvar cancer: a review

Cited by 31 publications

References 64 publications

Recent trends in surgical and reconstructive management of vulvar cancer: review of literature

Recent trends in surgical and reconstructive management of vulvar cancer: review of literature

Primary mucinous adenocarcinoma of the vulva: A case report and review of the literature

Development and validation of nomograms predicting cancer‐specific survival of vulvar cancer patients: based on the Surveillance, Epidemiology, and End Results Program

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