Diagnosis and treatment status of migraine: A clinic-based study in China

Li, Xuelian; Zhou, Jiying; Tan, Ge; Wang, Yunfeng; Li, Ran; Chen, Lixue

doi:10.1016/j.jns.2011.11.021

Cited by 20 publications

(19 citation statements)

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“…Prevalence of migraine in the general Chinese population was 9.3% in a nationwide survey [ 24 ], compared to 14.9% in United States [ 25 ]. Study found that under-diagnosis and misdiagnosis of migraine were common in China, which might be an explanation for the low frequency of personal/family history of migraine among our cohort [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Children with cyclic vomiting syndrome: phenotypes, disease burden and mitochondrial DNA analysis

Xue

Huang

2018

BMC Gastroenterol

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BackgroundCyclic vomiting syndrome (CVS) is characterized by repeated, stereotypical vomiting episodes. It is possibly associated with mitochondrial DNA (mtDNA) variants. We examined the phenotype, disease burden, treatment and performed mtDNA analysis in pediatric CVS.MethodsThis retrospective study included 42 children with CVS in a tertiary care center. Information regarding medical history, clinical features, laboratory tests, and treatment were collected. mtDNA sequencing was performed among 13 patients.ResultsMean age of onset among patients was 4.0±3.4 years, and mean age at diagnosis was 6.7±4.2 years. CVS episodes in onset and features were stereotypic. Recognizable prodromes were reported in 54.8% patients. Neuroimaging showed previously unknown intracranial abnormalities. Gastrointestinal infection was found in four patients. Mean duration of hospitalization was 7.0±2.4 days, and mean hospitalization cost was 10,891 RMB. Sequencing showed that 4/13 patients had C16519T mtDNA polymorphism, and 2/13 patients had G3010A mtDNA polymorphism.ConclusionsCyclic vomiting syndrome is a disabling disorder, which causes huge disease burdens to the patients and their families. Early clinical suspicion and prompt diagnosis are crucial. mtDNA polymorphisms were found in some patients, but they were not significantly associated with pediatric CVS.

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Section: Discussionmentioning

confidence: 99%

Children with cyclic vomiting syndrome: phenotypes, disease burden and mitochondrial DNA analysis

Xue

Huang

2018

BMC Gastroenterol

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“…The She ethnic population in Fujian Province, China, has its own lifestyle, cultural traditions, and genetic background that differ from those of Han Chinese and other Asian populations [6,7]. In our previous epidemiological study on migraines in the She population, the prevalence of migraines was as high as 10.53%, which is significantly higher than that in China overall (4.32%) [6,19]. Based on the five newly identified polymorphic loci from the abovementioned meta-analysis [17], we investigated the genotype distribution and allele frequency of those five polymorphic loci in the She population and Han Chinese to explore their correlation with migraines [20,21].…”

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confidence: 95%

Association between PRDM16, MEF2D, TRPM8, LRP1 gene polymorphisms and migraine susceptibility in the She ethnic population in China

Yang

et al. 2019

CIM

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Background:The prevalence of migraines in the She population, a minority in China, is significantly higher than that in Han Chinese and other Asian populations. Two single nucleotide polymorphisms (SNPs) have been found to be associated with migraine susceptibility in the She population.Purpose: This study investigated four SNPs, identified in genome-wide association studies, within migraine-susceptible loci in Han Chinese for their association with migraine susceptibility in the She population.Methods: Two-hundred unrelated migraine patients and 200 healthy controls were recruited. The SNPs examined included rs2651899 (PRDM16 ), rs2274316 (MEF2D ), rs7577262 (TRPM8) and rs11172113 (LRP1). Genotyping of the SNPs was performed by allele-specific polymerase chain reaction and direct sequencing.Results: No significant differences between the participants with migraines and controls (participants without migraines) were demonstrated in genotypes, alleles and allele carriage frequencies for the four SNPs. A subgroup analysis found that migraine with aura had a lower frequency of C allele positivity in rs2651899 than in healthy controls (59.6% vs. 74.5%, respectively; P < 0.034). Univariate analyses indicated that no genotype of the four SNPs had a significant association with migraines. Males had a lower risk of migraines, and advanced age was a significant risk factor for migraines in females. Conclusion:The SNPs in four migraine susceptible loci in Han Chinese were not risk factors for migraines in a relatively small sample of the She population.

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“…Only 10.8% of all CH patients who visited PLAGH (13/120) had previously been correctly diagnosed . Only 2.7% of those with migraine and no TTH patient had been given preventative medication. These data are in line with those of the epidemiological survey, which showed that only 13.8% of those with migraine (57/414) and 5.6% of TTH patients (28/501) had received appropriate diagnoses .…”

Section: Developments In Headache Care In Chinamentioning

confidence: 99%

“…Many patients with headache disorders were incorrectly diagnosed and treated. Of all patients, 13.5% of those with migraine, 5.6% of TTH patients, and no cluster headache (CH) patient had been correctly diagnosed prior to visiting FAHCMU. Only 10.8% of all CH patients who visited PLAGH (13/120) had previously been correctly diagnosed .…”

Section: Developments In Headache Care In Chinamentioning

confidence: 99%

Headache Care in China

Zhang

Zhou

et al. 2014

Headache

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Headache disorders are problematic worldwide. China is no different. A population-based door-to-door survey revealed that the 1-year prevalence of primary headache disorders in China was 23.8%, constituting a major societal burden. Many headache centers and clinics have been established in China, and headache disorders (and associated stress) are receiving an increased level of expert attention. This review summarizes the outcomes of the epidemiological survey and the progress of clinical and basic research in China, describes the present situation in terms of headache diagnosis and treatment, and discusses the future of headache care in China.

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Diagnosis and treatment status of migraine: A clinic-based study in China

Cited by 20 publications

References 14 publications

Children with cyclic vomiting syndrome: phenotypes, disease burden and mitochondrial DNA analysis

Children with cyclic vomiting syndrome: phenotypes, disease burden and mitochondrial DNA analysis

Association between PRDM16, MEF2D, TRPM8, LRP1 gene polymorphisms and migraine susceptibility in the She ethnic population in China

Headache Care in China

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