“…The brain uses glucose as its main source of energy and is susceptible to injury due to acute thiamine deficiency. Petechial hemorrhage and demyelination within periventricular structures (thalami, mammillary bodies, ocular motor nuclei, and cerebellar vermis) account for the classical triad of Wernicke's encephalopathy (WE), including confusion/encephalopathy, ophthalmoplegia, and ataxia . Additional symptoms and signs are reported in WE, implicating more widespread consequences of thiamine deficiency …”