Diagnosis, Management, and Outcome in 9 Children with Unilateral Posterior Synostotic Plagiocephaly

Abboud, Hilal; Rifi, Loubna; Melhaoui, Adyl; Arkha, Yasser; Ouahabi, Abdessamad El

doi:10.1016/j.wneu.2020.04.232

Cited by 4 publications

(5 citation statements)

References 21 publications

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“…In the anatomic ophthalmic domain, papilledema was the most reported anomaly in both non-syndromic 1% (n = 333; 95% CI 0-18) [18,[20][21][22] and syndromic craniosynostosis 18% (n = 474; 95% [18,20,21,[25][26][27][28][29][30][31][32][33][34]. In non-syndromic craniosynostosis, only one study reported papilledema in lambdoid craniosynostosis, with a prevalence of 67% (n = 9) [19]. This study was considered as an outlier and excluded from the quantitative analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, in non-syndromic craniosynostosis, one study reported papilledema in unicoronal craniosynostosis with a prevalence of 3% [20]. In syndromic craniosynostosis, papilledema was most prevalent in Crouzon syndrome 34% (n = 177; 95% CI [20,21,[25][26][27]29,30,34] and Apert syndrome 11% (n = 58; 95% CI [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] [20,26,29,31,34]. There are several reasons for the high occurrence of papilledema in syndromic craniosynostosis.…”

Section: Discussionmentioning

confidence: 99%

“…Compared to syndromic craniosynostosis papilledema was less common in non-syndromic craniosynostosis, with a prevalence of 6% (n = 333; 95% CI 0-18) [18][19][20][21][22]. It had the highest prevalence in lambdoid craniosynostosis 67% (n = 9) reported by one study, which was also considered as an outlier in the analysis [19]. After exclusion of outliers, the pooled prevalence of papilledema in non-syndromic craniosynostosis was 1% (n = 324; 95% CI 0-5).…”

Section: Non-syndromic Craniosynostosismentioning

confidence: 96%

“…All anatomical ophthalmic anomalies in non-syndromic craniosynostosis are sented in Table 2. Compared to syndromic craniosynostosis papilledema was less c mon in non-syndromic craniosynostosis, with a prevalence of 6% (n = 333; 95% CI 0 [18][19][20][21][22]. It had the highest prevalence in lambdoid craniosynostosis 67% (n = 9) repo Abbreviations: RS = Retrospective case study; CS = case-series; PS = prospective study; CFS = Craniofrontonasal dysplasia.…”

Section: Non-syndromic Craniosynostosismentioning

confidence: 99%

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Prevalence of Ocular Anomalies in Craniosynostosis: A Systematic Review and Meta-Analysis

Rostamzad

Arslan

Mathijssen

et al. 2022

JCM

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Background: The aim of this study was to describe the ophthalmic abnormalities and their prevalence in craniosynostosis prior to craniofacial surgery. Methods: A systematic search was conducted on Medline OVID, Embase, Cochrane, Google Scholar, Web of Science Core Collection. Inclusion criteria were English papers, children aged <18 years with non-syndromic and syndromic craniosynostosis, case reports, case series, and case-control studies. A system of domains was established consisting of an anatomic and functional ophthalmic domain. A meta-analysis of single proportions was carried out using random effects model and pooled mean proportions with 95% confidence intervals (CI) were calculated. Results: Thirty-two papers analyzing 2027 patients were included. Strabismus was the most common anomaly in non-syndromic craniosynostosis: Horizontal strabismus was highest prevalent in unicoronal craniosynostosis (UCS) 19% (95% CI 9–32), followed by vertical strabismus 17% (95% CI 5–33). In syndromic craniosynostosis, horizontal strabismus was most prevalent in Crouzon syndrome 52% (95 CI 26–76), followed by Apert syndrome 50% (95% CI 42–58). Vertical strabismus was most prevalent in Saethre-Chotzen 60% followed by Muenke’s syndrome 36%. Furthermore, astigmatism was the second most reported outcome in non-syndromic craniosynostosis and highest prevalent in UCS 35% (95% CI 21–51). In syndromic craniosynostosis, astigmatism was most frequently seen in Crouzon syndrome 43% (95% CI 22–65), followed by Apert syndrome 34% (95% CI 14–58). Moreover, in syndromic craniosynostosis, 5–40% had a decrease in visual acuity (VA) ≤ 0.3 LogMAR in the better eye and 11–65% had a VA ≤ 0.3 LogMAR in at least one eye. Discussion: This review demonstrates the high prevalence of ocular anomalies in non-syndromic and syndromic craniosynostosis. A multidisciplinary and systematic approach is needed for the screening and optimal treatment of these conditions in a timely manner.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Non-syndromic Craniosynostosismentioning

confidence: 96%

Section: Non-syndromic Craniosynostosismentioning

confidence: 99%

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Prevalence of Ocular Anomalies in Craniosynostosis: A Systematic Review and Meta-Analysis

Rostamzad

Arslan

Mathijssen

et al. 2022

JCM

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“…For example, in unilateral lambdoid synostosis the ear is posteriorly displaced toward the ipsilateral fused lambdoid suture, whereas in UCS there is an anterior displacement of the ear. 28 In both cases, the ear is displaced toward the respective fused suture. In metopic synostosis, the orbit is recessed with restricted lateral expansion; in UCS, the orbit is superiorly displaced, as the fused coronal suture prevents normal anterior expansion of the frontal bone, a phenomenon first described by Virchow in 1851.…”

Section: Discussionmentioning

confidence: 99%

Craniofacial Dysmorphology in Infants With Non-Syndromic Unilateral Coronal Craniosynostosis

Bellaire

Devarajan

Napoli

et al. 2022

Journal of Craniofacial Surgery

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Background: Unilateral coronal craniosynostosis (UCS) is a congenital disorder resulting from the premature suture fusion, leading to complex primary and compensatory morphologic changes in the shape of not only the calvarium and but also into the skull base. This deformity typically requires surgery to correct the shape of the skull and prevent neurologic sequelae, including increased intracranial pressure, sensory deficits, and cognitive impairment. Methods: The present multicenter study sought to reverse-engineer the bone dysmorphogenesis seen in non-syndromic UCS using a geometric morphometric approach. Computed tomography scans for 26 non-syndromic UCS patients were converted to three-dimensional mesh models. Two hundred thirty-six unique anatomical landmarks and semi-landmarked curves were then plotted on each model, creating wireframe representations of the Patients’ skulls. Results: Generalized Procrustes superimposition, Principal Component Analysis, and heatmaps identified significant superior displacement of the ipsilateral orbit (“harlequin” eye deformity), anterior displacement of the ear ipsilateral to the fused coronal suture, acute deviation of midline skull base structures ipsilateral to the fused coronal suture and flattening of the parietal bone and associated failure to expand superiorly. Conclusions: The described technique illustrates the impact of premature coronal suture fusion on the development of the entire skull and proposes how bone dysmorphology contributes to the Patients’ neurologic sequelae. By bridging novel basic science methodologies with clinical research, the present study quantitatively describes craniofacial development and bone dysmorphogenesis.

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Computed tomography quantitative analysis of cranial vault dysmorphology and severity of facial complex changes in posterior synostotic plagiocephaly patients

Calandrelli,

Pilato,

Massimi

et al. 2023

Childs Nerv Syst

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Diagnosis, Management, and Outcome in 9 Children with Unilateral Posterior Synostotic Plagiocephaly

Cited by 4 publications

References 21 publications

Prevalence of Ocular Anomalies in Craniosynostosis: A Systematic Review and Meta-Analysis

Prevalence of Ocular Anomalies in Craniosynostosis: A Systematic Review and Meta-Analysis

Craniofacial Dysmorphology in Infants With Non-Syndromic Unilateral Coronal Craniosynostosis

Computed tomography quantitative analysis of cranial vault dysmorphology and severity of facial complex changes in posterior synostotic plagiocephaly patients

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