Diagnosis of allergic sensitization in patients with allergic rhinitis and asthma in a tropical environment

Sánchez-Borges, Mario; Capriles‐Hulett, Arnaldo; Torres, Joselit; Ansotegui, Ignacio J.; Castillo, Adolfo; Dhersy, Ariadne; Monzón, Xiomara

doi:10.29262/ram.v66i1.570

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…Furthermore, diagnosed asthma to HDM and IgE to nDer p 1, 2, and 10 predicted a higher risk for clinically relevant shrimp allergy. 131 Tropical climates, although scarcely studied, are a suitable environment for the development of mite sensitization; indeed, mites are the most prevalent allergen source in the tropics, followed by pets and cockroaches, 132 whereas pollen and molds are less relevant than in North America and Europe. In tropical places where helminth infections are prevalent, cross-reactivity between mites and tropomyosins from the nematode Ascaris lumbricoides are associated with asthma symptoms.…”

Section: House Dust Mitesmentioning

confidence: 99%

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Ansotegui¹,

Melioli²,

Canonica³

et al. 2020

World Allergy Organization Journal

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Precision allergy molecular diagnostic applications (PAMD@) is increasingly entering routine care. Currently, more than 130 allergenic molecules from more than 50 allergy sources are commercially available for in vitro specific immunoglobulin E (sIgE) testing. Since the last publication of this consensus document, a great deal of new information has become available regarding this topic, with over 100 publications in the last year alone. It thus seems quite reasonable to publish an update. It is imperative that clinicians and immunologists specifically trained in allergology keep abreast of the new and rapidly evolving evidence available for PAMD@. PAMD@ may initially appear complex to interpret; however, with increasing experience, the information gained provides relevant information for the allergist. This is especially true for food allergy, Hymenoptera allergy, and for the selection of allergen immunotherapy. Nevertheless, all sIgE tests, including PAMD@, should be evaluated within the framework of a patient's clinical history, because allergen sensitization does not necessarily imply clinical relevant allergies.

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Section: House Dust Mitesmentioning

confidence: 99%

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Ansotegui¹,

Melioli²,

Canonica³

et al. 2020

World Allergy Organization Journal

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“…Por otro lado, los agentes sensibilizantes más frecuentes fueron el polen de olivo (18%) en Jordania (6) y los pólenes de gramineas (48%), de árboles (34%) y de malezas (18%) en un estudio realizado en España (18) . Otros estudios reportan a los insectos en el segundo o tercer lugar de frecuencia, alcanzando el 21,6% (19) , el 26,1% (13) o el 32% (17) . La alta sensibilización a insectos que se encuentra en nuestro estudio puede deberse a diferencias en los entornos de vivienda y comunidad (13) .…”

Section: Discussionunclassified

“…En contraste, Candida albicans y Cladosporum fueron los hongos predominantes en un estudio colombiano en el 12,9% de los pacientes (20) . La frecuencia de sensibilización fue similar para epitelio de perro y gato; resultados similares se evidencian en otros reportes (13,14,(16)(17)(18)(19) .…”

Section: Discussionunclassified

Sensibilización a aeroalérgenos en una población pediátrica peruana con enfermedades alérgicas

García-Gomero

López-Talledo

Galván-Calle

et al. 2020

Rev Peru Med Exp Salud Publica

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Con el objetivo de determinar el perfil de sensibilización a aeroalérgenos en pacientes pediátricos con asma y/o rinitis alérgica se realizó un estudio transversal en 411 pacientes usando una prueba cutánea de alergia. Se analizó la edad, sexo, nivel de IgE total y eosinófilos. La edad media fue de 8,1 ± 3,7 años y el 60,6% fueron varones. La media de los eosinófilos y el nivel de IgE total fue de 450,1 ± 377,3 células/mm3 y 861,7 ± 757,6 IU/mL, respectivamente. Los ácaros fueron los alérgenos sensibilizantes más frecuentes (79,8%) y el Dermatophagoides farinae (65,2%) fue el más común. La polisensibilización estuvo presente en el 76,2% de los pacientes. La sensibilización se evidenció en la mayoría de los pacientes con asma y/o rinitis alérgica y estuvo asociada con la edad, grupos etarios y nivel de IgE total.

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“…The role of inhalant allergens (16)(17)(18)(19)(20)(21) in inducing immunopathological features based on allergen-specific T-helper (Th-2) cell response with eosinophils and T-lymphocytes predominant airway inflammation, thickening of the basement membrane and goblet-cell hyperplasia has been established both in asthma and AR (22,24). Usually, early onset allergic asthma is associated with allergic sensitization and AR (13).…”

Section: Allergic Rhinitis (Ar) and Asthmamentioning

confidence: 99%

Manifesto on united airways diseases (UAD): an Interasma (global asthma association – GAA) document

et al. 2021

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The large amount of evidence and the renewed interest on upper and lower airways involvement in infectious and inflammatory diseases has led Interasma (Global Asthma Association) to take a position on United Airways Diseases (UAD). Starting from an extensive literature review, Interasma excecutive committee discussed and approved this Manifesto developed by Interasma scientific network (INES) members. The manifesto describes the evidence gathered to date and defines, states, advocates, and proposes issues on UAD (rhinitis, rhinosinusitis and nasal polyposis), and concomitant/comorbid lower airways disorders (asthma, chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis, obstructive sleep apnoea) with the aim of challenging assumptions, fostering commitment, and bringing about change.UAD refer to clinical pictures characterized by the coexistence of upper and lower airways involvement, driven by a common pathophysiological mechanism, leading to a greater burden on patient's health status and requiring an integrated diagnostic and therapeutic plan.The high prevalence of UAD must be taken into account. Upper and lower airways diseases influence disease control and patient's quality of life. Patients with UAD need to have a timely and adequate diagnosis, treatment, and, when recommended, referral for management in a specialized center. Diagnostic testing including skin prick or serum specific IgE, lung function, fractional exhaled nitric oxide (FeNO), polysomnography, allergen-specific immunotherapies, biological therapies and homebased continuous positive airway pressure (CPAP) whenever these are recommended, should be part of the management plan for UAD.Education of medical students, physicians, health professionals, patients and caregivers on the UAD is needed.

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Diagnosis of allergic sensitization in patients with allergic rhinitis and asthma in a tropical environment

Cited by 6 publications

References 14 publications

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Sensibilización a aeroalérgenos en una población pediátrica peruana con enfermedades alérgicas

Manifesto on united airways diseases (UAD): an Interasma (global asthma association – GAA) document

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