“…After title/abstract review, 165 papers were evaluated in full text. Of these, 14 [3] , [4] , [6] , [9] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] were included in the qualitative and quantitative synthesis ( Fig. 1 ).…”
Section: Resultsmentioning
confidence: 99%
“…1 ). Out the 14 studies, 2 studies only analyzed children and young adults [15] , [21] , and only 4 studies analyzed sub-types of AAD [4] , [6] , [16] , [8] . The reasons for exclusion of the remaining 151 papers are detailed in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Overall, 538 OHCAs occurred due to AADs in a total of 9475 OHCA due to intrinsic causes. Nine studies reported on Asian cohorts (7 from Japan, 1 Taiwan and 1 South Korea) [6] , [9] , [16] , [17] , [18] , [20] , [22] , [23] , 2 studies reported on European cohorts (Germany and Czech Republic) [11] , [13] and 3 other studies were from the American continent (2 from USA and 1 from Canada) [15] , [19] , [21] .…”
Section: Resultsmentioning
confidence: 99%
“…Only 4 studies gave independent data on types of aortic dissection [4] , [6] , [16] , [18] . One study [6] performed a comparative analysis of patients who developed OHCA due to acute aortic dissections (AAD- OHCA) with non-AAD OHCA patients and found no significant differences between both groups.…”
Section: Resultsmentioning
confidence: 99%
“…Greater insight in this subject becomes increasingly important, in order to assist with clinical decision-making. While the prognosis of AAD as a cause of OHCA is currently dire [6] , only the comprehensive knowledge of its incidence can lead to successful clinical pathways in the management of these patients.…”
Objectives
Acute Aortic dissection (AAD) may present as out-of-hospital cardiac arrest (OHCA). However, the incidence of this presentation is not well known. Our aim was to perform a systematic review and meta-analysis of all observational studies reporting on the incidence of AAD in patients with OHCA.
Methods
We searched MEDLINE, CENTRAL, PsycInfo, Web of Science Core Collection and OpenGrey databases from inception to March-2021, for observational studies reporting on the incidence of AAD in patients with OHCA. Data was pooled using a random-effects model of proportions. The primary outcome was the incidence of AAD in OHCA patients. Secondary outcomes were the incidence of type A aortic dissections (TAAD) and type B aortic dissections (TBAD) in OHCA patients, overall mortality following AAD-OHCA and risk of death in AAD-OHCA patients compared to risk of death of non-AAD-OHCA patients.
Results
Fourteen studies were included. The pooled calculated incidence of OHCA due to AAD was 4.39% (95 %CI: 2.55; 6.8). Incidence of OHCA due to TAAD was 7.18% (95 %CI: 5.61; 8.93) and incidence of OHCA due to TBAD was 0.47% (95 %CI: 0.18; 0.85). Overall mortality following OHCA due to AAD was 100% (95 %CI: 97.62; 100). The risk of death in AAD-OHCA patients compared with non-AAD-OHCA patients was 1.10 (95 %CI: 0.94; 1.30).
Conclusion
AAD as a cause of OHCA is more frequent than previously thought. Prognosis is dire, as it is invariably lethal. These findings should lead to a higher awareness of AAD when approaching a patient with OHCA and to future studies on this matter.
“…After title/abstract review, 165 papers were evaluated in full text. Of these, 14 [3] , [4] , [6] , [9] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] were included in the qualitative and quantitative synthesis ( Fig. 1 ).…”
Section: Resultsmentioning
confidence: 99%
“…1 ). Out the 14 studies, 2 studies only analyzed children and young adults [15] , [21] , and only 4 studies analyzed sub-types of AAD [4] , [6] , [16] , [8] . The reasons for exclusion of the remaining 151 papers are detailed in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Overall, 538 OHCAs occurred due to AADs in a total of 9475 OHCA due to intrinsic causes. Nine studies reported on Asian cohorts (7 from Japan, 1 Taiwan and 1 South Korea) [6] , [9] , [16] , [17] , [18] , [20] , [22] , [23] , 2 studies reported on European cohorts (Germany and Czech Republic) [11] , [13] and 3 other studies were from the American continent (2 from USA and 1 from Canada) [15] , [19] , [21] .…”
Section: Resultsmentioning
confidence: 99%
“…Only 4 studies gave independent data on types of aortic dissection [4] , [6] , [16] , [18] . One study [6] performed a comparative analysis of patients who developed OHCA due to acute aortic dissections (AAD- OHCA) with non-AAD OHCA patients and found no significant differences between both groups.…”
Section: Resultsmentioning
confidence: 99%
“…Greater insight in this subject becomes increasingly important, in order to assist with clinical decision-making. While the prognosis of AAD as a cause of OHCA is currently dire [6] , only the comprehensive knowledge of its incidence can lead to successful clinical pathways in the management of these patients.…”
Objectives
Acute Aortic dissection (AAD) may present as out-of-hospital cardiac arrest (OHCA). However, the incidence of this presentation is not well known. Our aim was to perform a systematic review and meta-analysis of all observational studies reporting on the incidence of AAD in patients with OHCA.
Methods
We searched MEDLINE, CENTRAL, PsycInfo, Web of Science Core Collection and OpenGrey databases from inception to March-2021, for observational studies reporting on the incidence of AAD in patients with OHCA. Data was pooled using a random-effects model of proportions. The primary outcome was the incidence of AAD in OHCA patients. Secondary outcomes were the incidence of type A aortic dissections (TAAD) and type B aortic dissections (TBAD) in OHCA patients, overall mortality following AAD-OHCA and risk of death in AAD-OHCA patients compared to risk of death of non-AAD-OHCA patients.
Results
Fourteen studies were included. The pooled calculated incidence of OHCA due to AAD was 4.39% (95 %CI: 2.55; 6.8). Incidence of OHCA due to TAAD was 7.18% (95 %CI: 5.61; 8.93) and incidence of OHCA due to TBAD was 0.47% (95 %CI: 0.18; 0.85). Overall mortality following OHCA due to AAD was 100% (95 %CI: 97.62; 100). The risk of death in AAD-OHCA patients compared with non-AAD-OHCA patients was 1.10 (95 %CI: 0.94; 1.30).
Conclusion
AAD as a cause of OHCA is more frequent than previously thought. Prognosis is dire, as it is invariably lethal. These findings should lead to a higher awareness of AAD when approaching a patient with OHCA and to future studies on this matter.
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