Diagnosis of asthma – new theories

Löwhagen, O.

doi:10.3109/02770903.2014.991971

Cited by 31 publications

(18 citation statements)

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“…Chronic allergic asthma is characterized by persistent airway inflammation, hyperresponsiveness (AHR) and structural changes in the lungs collectively known as airway remodeling [ 4 , 5 ]. AHR is an exaggerated airway narrowing caused by nonspecific irritants or agonists associated with increased lung infiltration by inflammatory cells [ 6 ]. The persistent AHR in patients refractory to steroid therapy is associated with airflow limitation or remodeled airway leading to a change in mechanical properties [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Downregulation of semaphorin 3E promotes hallmarks of experimental chronic allergic asthma

et al. 2017

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Guidance cues such as semaphorins are attractive novel therapeutic targets for allergic disorders. We have previously described an inhibitory effect of semaphorin 3E (Sema3E) on human airway smooth muscle cell function. We have further addressed a canonical role for Sema3E in acute model of allergic asthma in vivo. Considering the chronic nature of the disease, the potential implication of Sema3E to alleviate long-lasting deficits should be investigated. Expression of Sema3E in a chronic model of allergic asthma was assessed after exposure to house dust mite (HDM) as a clinically relevant allergen. Chronic features of allergic asthma including airway hyper-responsiveness (AHR), inflammation, and remodeling were studied in Sema3E-deficient mice. Additionally, the effect of exogenous Sema3E treatment was evaluated in prophylactic and therapeutic experimental models. We have demonstrated that expression of Sema3E is robustly suppressed in the airways upon chronic HDM exposure. Chronic allergic airway disease was significantly augmented in Sema3E-deficient mouse model which was associated with an increased AHR, remodeling, and Th2/Th17 inflammation. Intranasal Sema3E administration restored chronic deficits of allergic asthma in mice. Data from this study unveil a key regulatory role of Sema3E in chronic course of asthma via orchestration of impaired inflammatory and remodeling responses.

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Section: Introductionmentioning

confidence: 99%

Downregulation of semaphorin 3E promotes hallmarks of experimental chronic allergic asthma

et al. 2017

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“…Asthma is one of the most prevalent chronic diseases around the world (1). Moreover, due to the increase in its prevalence, severity, and effects on various individual, familial, economic, and health system dimensions, the epidemiology of asthma diseases is of utmost importance (2,3).…”

Section: Introductionmentioning

confidence: 99%

The effect of educational intervention on self-care learning in patients with asthma; the results of a randomized clinical trial

Kaveh¹,

Haghshenas²,

Ghayyoumi³

et al. 2018

Immunopathol Persa

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Introduction: Asthma is one of the prevalent and costly diseases. Various studies have shown that self-care plays a major role in preventing the complications, improving the life quality, and reducing the care expenditures of asthma. Therefore, strengthening the asthma patients in caring for themselves and using planned trainings is highly necessary. Objectives: The present study aimed to investigate the effect of education on self-care learning in the patients suffering from asthma. Patients and Methods: The present interventional study was conducted on 80 patients referring to specialized clinics of Shiraz University of Medical Sciences who had the inclusion criteria of the study. The patients were selected through convenient sampling and randomly assigned to either the control or the intervention group. The educational intervention included five sessions of training on self-care. The study data were collected using a demographic questionnaire as well as a knowledge assessment test and the results were analyzed through the SPSS statistical software. Results: The study results revealed no significant difference between the two groups regarding the demographic variables. However, comparison of the mean of changes in the two groups› knowledge scores showed a significant increase in the intervention group›s knowledge score (P<0.001). Conclusion: The findings of this study confirmed the patients› need for learning self-care methods as well as the effectiveness of planned educational programs. Therefore, using and strengthening selfcare trainings are highly recommended for asthma patients in clinics.

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“…Recently, Löwhagen has published a very interesting review article in the Journal of Asthma [1]. The author introduces 8 new theories related to inflammation, hyper responsiveness, obstruction and symptoms of asthma.…”

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confidence: 99%

“…The author introduces 8 new theories related to inflammation, hyper responsiveness, obstruction and symptoms of asthma. Moreover, Löwhagen highlights some actions that represent advances for the diagnostic investigation [1]. All theories are very relevant.…”

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confidence: 99%

“…So, how is it possible to do the diagnosis of asthma in patients unable to perform a proper spirometry? Löwhagen suggests that in these cases, spirometry should be supplemented by non-effort-demanding methods, such as body plesthysmography or impulse oscillometry (IOS) [1]. It is tempting to look favourably upon IOS as an additional or alternative test for spirometry.…”

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confidence: 99%

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