Diagnosis of Atopic Dermatitis: Mimics, Overlaps,  and Complications

Siegfried, Elaine C.; Hebert, Adelaide A.

doi:10.3390/jcm4050884

Cited by 104 publications

(96 citation statements)

References 78 publications

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“…Concomitant psoriasis and atopic dermatitis is occasionally encountered, and many children with psoriasis have a psoriasiform dermatitis that is intermediate between psoriasis and dermatitis, often without the sharply delineated, very scaly lesions that are typical of psoriasis in adults. This condition is also referred to as overlap, eczematous psoriasis, or psoriasiform eczema …”

Section: Differential Diagnosismentioning

confidence: 99%

Pediatric psoriasis: Evolving perspectives

Eichenfield

Paller

Tom

et al. 2018

Pediatric Dermatology

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Section: Differential Diagnosismentioning

confidence: 99%

Pediatric psoriasis: Evolving perspectives

Eichenfield

Paller

Tom

et al. 2018

Pediatric Dermatology

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“…The association between the 2 conditions has been described as psoriasis-eczema overlap or eczematous psoriasis. Typically, people with psoriasis-eczema overlap have both flexural eczema and psoriatic lesions, and although no thick plaques are present, patients experience more intense itching than in isolated psoriasis [35] (Figure 15). …”

Section: Psoriasiform Dermatitismentioning

confidence: 99%

Atopic Dermatitis in Adults: A Diagnostic Challenge

Salvador¹,

Romero‐Pérez²,

Encabo-Durán³

2017

J Investig Allergol Clin Immunol

150

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Atopic dermatitis (AD) has a prevalence of 1%-3% in adults. Adult-onset AD has only been defined recently, and lack of familiarity with this condition and confusion regarding the appropriate terminology persist. AD may first appear in childhood or de novo in adults and is characterized by pronounced clinical heterogeneity. The disease often deviates from the classic pattern of flexural dermatitis, and there are forms of presentation that are specific to adults, such as head-and-neck dermatitis, chronic eczema of the hands, multiple areas of lichenification, or prurigo lesions. Although diagnosis is clinical, adult-onset AD frequently does not fit the traditional diagnostic criteria for the disease, which were developed for children. Thus, AD is often a diagnosis of exclusion, especially in de novo cases. Additional diagnostic tests, such as the patch test, prick test, skin biopsy, or blood test, are usually necessary to rule out other diseases or other types of eczema appearing concomitantly with AD. This article presents an update of the different forms of clinical presentation for AD in adults along with a proposed diagnostic approach, as new treatments will appear in the near future and many patients will not be able to benefit from them unless they are properly diagnosed. Key words: Atopic dermatitis. Adult. Diagnosis. Patch testing. Prick testing. ResumenLa dermatitis atópica (DA) en el adulto tiene una prevalencia del 1-3%. Es una entidad de reciente acuñamiento, que no todo el mundo conoce y sobre la que existe una gran confusión terminológica. Puede iniciarse en la infancia o presentarse de "novo" en el adulto. Presenta una gran heterogeneidad clínica y con frecuencia no sigue el patrón clásico de dermatitis flexural. Además, existen formas de presentación más propias de adulto como son la dermatitis de la cabeza y el cuello, eczema crónico de manos, áreas de liquenificación múltiple o lesiones de prurigo. Aunque su diagnóstico es clínico, muchas veces la DA del adulto no cumple los criterios diagnósticos "clásicos" de DA, pues están pensados para niños. Por eso, suele ser un diagnóstico de exclusión, sobre todo los casos de "novo". Suele precisar de la realización de pruebas diagnósticas para descartar otras enfermedades distintas u otro tipo de eczema sobreañadido a la DA. Las pruebas diagnósticas que pueden resultar útiles para ello son: pruebas epicutáneas, prick test, biopsia cutánea y una analítica sanguínea. Realizamos una actualización de las distintas formas de presentación clínica de la DA del adulto y establecemos unas pautas para llegar a su diagnóstico, pues en un futuro inmediato, con la aparición de nuevos tratamientos, muchos de estos pacientes no podrán beneficiarse de los mismos por no estar adecuadamente diagnosticados. Palabras clave: Dermatitis atópica. Adulto. Diagnóstico. Pruebas epicutáneas. Prick test.

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“…To the Editor, Some children present with a so-called overlap condition with clinical features of both psoriasis and atopic dermatitis (AD), previously described as 'psoriasis dermatitis' (PD). [1][2][3] Though its existence is not questioned in literature, only one study demonstrated clinical characteristics of children with coexisting psoriasis and AD, 2 and its course over time has not been described so far.…”

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confidence: 99%