Diagnosis of Bladder Cancer With Microelectromechanical Systems-based Cystoscopic Optical Coherence Tomography

Ren, Hugang; Waltzer, Wayne C.; Bhalla, Rahuldev S.; Liu, Jingxuan; Yuan, Zhijun; Lee, Christopher S. D.; Darras, Frank; Schulsinger, David A.; Adler, Henry J.; Kim, Jason; Mishail, Alek; Pan, Yingtian

doi:10.1016/j.urology.2009.04.090

Cited by 43 publications

(39 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diseased regions were created using an excise-and-fill method, similar to a previously described process [16]; small sections of the phantom were excised during various steps of the fabrication process and then filled with Dragon Skin, the properties of which depended on the desired end diseased state. A brief overview of the relevant diseased states follows stemming from insights published in literature [7,9,10,24]. Pre-cancerous dysplastic lesions manifest as a thickening of the uroltheliem, appear flat under WLC, and do not exhibit fluorescent contrast under BLC.…”

Section: Phantom Fabricationmentioning

confidence: 99%

See 1 more Smart Citation

Multimodal 3D cancer-mimicking optical phantom

Smith¹,

Lurie²,

Zlatev³

et al. 2016

Biomed. Opt. Express

View full text Add to dashboard Cite

Three-dimensional (3D) organ-mimicking phantoms provide realistic imaging environments for testing various aspects of optical systems, including for evaluating new probe designs, characterizing the diagnostic potential of new technologies, and assessing novel image processing algorithms prior to validation in real tissue. We introduce and characterize the use of a new material, Dragon Skin (Smooth-On Inc.), and fabrication technique, air-brushing, for fabrication of a 3D phantom that mimics the appearance of a real organ under multiple imaging modalities. We demonstrate the utility of the material and technique by fabricating the first 3D, hollow bladder phantom with realistic normal and multi-stage pathology features suitable for endoscopic detection using the gold standard imaging technique, white light cystoscopy (WLC), as well as the complementary imaging modalities of optical coherence tomography and blue light cystoscopy, which are aimed at improving the sensitivity and specificity of WLC to bladder cancer detection. The flexibility of the material and technique used for phantom construction allowed for the representation of a wide range of diseased tissue states, ranging from inflammation (benign) to high-grade cancerous lesions. Such phantoms can serve as important tools for trainee education and evaluation of new endoscopic instrumentation.

show abstract

Section: Phantom Fabricationmentioning

confidence: 99%

“…Recently, OCT and BLC have shown great promise as adjunct technologies to traditional WLC for bladder cancer detection [6][7][8][9][10]. A hurdle in the development and testing of new imaging technologies, however, is the lack of a large animal model for bladder cancer to yield diseased samples of reasonable size.…”

Section: Introductionmentioning

confidence: 99%

Multimodal 3D cancer-mimicking optical phantom

Smith¹,

Lurie²,

Zlatev³

et al. 2016

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…Of the 45 studies, only 9 met the inclusion criteria and were considered suitable for inclusion in the meta-analysis for OCT and bladder cancer ( Fig. 1) (4,(17)(18)(19)(20)(21)(22)(23)(24). All the eligible studies were published between 2002 and 2014.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic accuracy of optical coherence tomography in bladder cancer patients: A systematic review and meta-analysis

Huang

Zhang

et al. 2018

mol clin onc

View full text Add to dashboard Cite

Abstract.A meta-analysis was performed to evaluate the accuracy of optical coherence tomography (OCT) for diagnostic accuracy studies in bladder cancer patients. English language studies reporting the diagnostic accuracy of OCT for bladder cancer were retrieved from the PubMed, EMBASE and Cochrane Library databases in December 2014. Histopathology was a reference standard. Sensitivities, specificities, positive likelihood ratios and negative likelihood ratios were calculated, and summary receiver operating characteristic curves were drawn to determine the diagnostic accuracy of OCT. Finally, 9 eligible studies (468 patients) were included in our meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of OCT were 0.96 [95% confidence interval (CI): 0.94-0.98], 0.82 (95% CI: 0.80-0.85), 6.83 (95% CI: 3.24-14.1) and 0.05 (95% CI: 0.02-0.16), respectively. The summary diagnostic odds ratio was 138.88 (95% CI: 29.63-650.89) and the overall area under the curve was 0.9735. These results suggest that OCT has excellent diagnostic performance in patients with bladder cancer and recurrent lesions.

show abstract

“…Recent technological advances have enabled real-time two-dimensional (2D) and three-dimensional (3D) OCT imaging, Doppler OCT for functional subsurface blood flow imaging, ultrahigh-resolution OCT for subcellular imaging, and endoscopic OCT for noninvasive imaging of various internal organs. [8][9][10] Meanwhile, preclinical and clinical studies have demonstrated the utility of OCT in delineating morphological details of biological tissues (e.g., skin, oral cavity, esophagus, colon, bladder, and cervix), [11][12][13] and thus the potential for detecting cancers in these organs.…”

Section: Introductionmentioning

confidence: 99%

“…While our recent human study showed the clinical feasibility of our endoscopic OCT to significantly enhance early bladder cancer diagnosis, 10 here we present a pilot feasibility study on fresh human fetal membrane specimens from normal controls and from patients with MCP to explore the potential of OCT for early detection of pathological changes, which might serve in the prediction of preeclampsia or other diseases associated with pregnancy. We compare the image results of OCT and high-frequency ultrasound (HFUS) with the corresponding histological counterparts (clinical standard), so that the utility and potential limitations of OCT for high-resolution delineation of the morphology of human FMs and identification of pathological changes can be examined.…”

Section: Introductionmentioning

confidence: 99%

High-resolution imaging diagnosis of human fetal membrane by three-dimensional optical coherence tomography

et al. 2011

Self Cite

View full text Add to dashboard Cite

Abstract. Microscopic chorionic pseudocyst (MCP) arising in the chorion leave of the human fetal membrane (FM) is a clinical precursor for preeclampsia which may progress to fatal medical conditions (e.g., abortion) if left untreated. To examine the utility of three-dimensional (3D) optical coherence tomography (OCT) for noninvasive delineation of the morphology of human fetal membranes and early clinical detection of MCP, 60 human FM specimens were acquired from 10 different subjects undergoing term cesarean delivery for an ex vivo feasibility study. Our results showed that OCT was able to identify the four-layer architectures of human FMs consisting of high-scattering decidua vera (DV, average thickness d DV ≈ 92 ± 38 μm), low-scattering chorion and trophoblast (CT, d CT ≈ 150 ± 67 μm), high-scattering subepithelial amnion (A, d A ≈ 95 ± 36 μm), and low-scattering epithelium (E, d E ≈ 29 ± 8 μm). Importantly, 3D OCT was able to instantaneously detect MCPs (low scattering due to edema, fluid buildup, vasodilatation) and track (staging) their thicknesses d MCP ranging from 24 to 615 μm. It was also shown that high-frequency ultrasound was able to compliment OCT for detecting more advanced thicker MCPs (e.g., d MCP >615 μm) because of its increased imaging depth. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

show abstract

Diagnosis of Bladder Cancer With Microelectromechanical Systems-based Cystoscopic Optical Coherence Tomography

Cited by 43 publications

References 15 publications

Multimodal 3D cancer-mimicking optical phantom

Multimodal 3D cancer-mimicking optical phantom

Diagnostic accuracy of optical coherence tomography in bladder cancer patients: A systematic review and meta-analysis

High-resolution imaging diagnosis of human fetal membrane by three-dimensional optical coherence tomography

Contact Info

Product

Resources

About