Diagnosis of Breast Cancer Based on FT-IR Spectroscopy

Venkatachalam, P.; Rao, Lakshmi; Kumar, Neeraj; Jose, A Teixeira; Nazeer, Shaiju S.

doi:10.1063/1.3046195

Cited by 12 publications

(14 citation statements)

References 9 publications

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“…are arising from C-OH stretching vibrations of collagen carbohydrate moieties, C-N stretching vibrations of the collagen backbone and CH 2 wagging vibrations of collagen side chains (Li et al 2002, Venkatachalam et al 2008. In addition to lipids, proteins and nucleic acids, carbohydrates are also presented in all cells.…”

Section: Results Of Ftir Spectroscopymentioning

confidence: 99%

The Use of Fourier Infrared Spectroscopy and Laser – Raman Spectroscopy in Bladder Malignancy Diagnosis, A comparative Study

Ahmed¹,

Almuslet²,

Ahmed³

et al. 2010

APR

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Bladder cancer is one of the most common cancers in Africa. It takes several days to reach a diagnosis using histological examinations of specimens obtained by endoscope, which increases the medical expense. Spectroscopic analysis of bladder cancer tissues has received considerable attention due to its sensitivity to biochemical variations in the samples. The present study investigated the use of FTIR and laser Raman spectrometer as diagnose tools of bladder cancer. Fourteen bladder samples were collected from 7 patients during surgery from different hospitals without any pretreatment. FTIR, with a ceramic source, was used to differentiate between normal and cancerous bladder tissues via the change in the spectra of these samples. The investigations detected obvious spectroscopic change in the proteins (1650, 1550 cm With FT Raman spectrometer supplied with Nd:YAG laser, as an excitation light source, samples were studied and significant differences between the normal and cancerous bladder tissues were found around Raman shifts of 1650 cm -1 , 1440 cm -1 , 1270 cm -1 and 1080 cm -1 . The comparison between the two techniques showed that Raman spectroscopy holds much promising as a rapid, sensitive, nondestructive method, and easy to use as an alternative method for identification and diagnosis of bladder cancerous tissues.

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Section: Results Of Ftir Spectroscopymentioning

confidence: 99%

The Use of Fourier Infrared Spectroscopy and Laser – Raman Spectroscopy in Bladder Malignancy Diagnosis, A comparative Study

Ahmed¹,

Almuslet²,

Ahmed³

et al. 2010

APR

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“…13 FTIR spectroscopy has been widely applied in various research studies including plants, 14,15 animals, 16–18 microorganisms, 19,20 food 21–23 and human diseases, 24–26 for various types of samples including serum, 27,28 urine, 29,30 cell lines, 31 and tissue sections. 32,33 Although a wide range of biological studies have been covered by FTIR spectroscopy, most of the analyses are based on the full spectrum, peak frequency shift 34 and intensity of the bands, 35,36 the relative ratios 37–39 of the vibrating groups and so on, 40 while in this study, we found that the similarity of the full spectrum between the HCC foci and the paracancerous tissue makes it difficult to identify the groups by some machine learning techniques, and hence, the peak areas of the spectra were calculated and selected as the features to perform the classification models of k -nearest neighbor (KNN), random forest (RF) and support vector machine (SVM). These models were evaluated through 5-fold cross-validation, and the index of precision, recall and F 1-score were used to characterize the performance.…”

Section: Introductionmentioning

confidence: 90%

Identification of hepatocellular carcinoma and paracancerous tissue based on the peak area in FTIR microspectroscopy

Peng¹,

Yin²,

Ma³

et al. 2022

Anal. Methods

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“…The transformation of the interferogram into spectrum is carried out mathematically with a dedicated online computer [6], FT-IR has shown as a sensitive diagnostic tool to distinguish cancerous from normal tissues in colon [7], prostate [8], breast [9], cervical [10], gastric [11], oral [12] and esophageal [13], bladder [14]. The purpose of this study is to assess the possibility of using Fourier transform infrared spectroscopy (FT-IR) as a diagnostic tool for cancer detection by observing the biochemical changes between tumour and normal cells within a wavenumber range known as the "fingerprint region" (encompassing 1800 to 950 cm -1 ) [15] to distinguish between normal (N) and abnormal breast tissues, and to classify the abnormal tissues in different subtypes such as hyperplasia (H) and fibroadenoma (F) as a benign tissues, and ductal carcinoma (DC) as a malignant tissues.…”

Section: Introductionmentioning

confidence: 99%

Human breast tissue cancer diagnosis by FT-IR spectroscopy

Yousif¹,

Fawaz²,

Mohamed³

2015

JUAPS

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Fourier transform infrared (FT-IR) spectroscopic study of normal, benign and carcinomal human breast tissues has been carried out. To our best knowledge, this work is the first statistical research on FT-IR spectroscopy-based diagnosis of breast cancers among the Iraqi women. Because of FT-IR sensitivity to the changes in the biomolecules in the tissues, it can be used for qualitative and quantitative analysis of cancerous breast tissues. FT-IR spectra ware taken for 91 samples of breast tissues that were previously histopathologically identified by pathologist experienced as: 63 normal (N) samples, 8 hyperplasia (H) samples, 10 fibro adenoma (F) samples, 10 ductal carcinoma (DC) samples. Several spectral differences were detected in the frequency range between 400 cm -1 and 4000 cm -1 . The ratio of intensities of the bands of A2925/A2854, A1653/A1545, A1343/A1450, A1083/A1236 and A1163/A1545 supplied conformational changes of lipids, protein, collagen, nucleic acids, and carbohydrates respectively in the breast tissues. There are remarkable differences in the spectral features between normal, benign and malignant tissues because of changes in molecules structure that accompany the transformation from a normal to a cancerous state during carcinogenesis, where the concentration of lipid is lower in cancerous breast tissues, as opposed to normal breast tissues, while the content of DNA, protein and collagen have been increased in benign and cancerous tissues . These differences in the spectral information may serve for the diagnosis of breast cancer.

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Diagnosis of Breast Cancer Based on FT-IR Spectroscopy

Cited by 12 publications

References 9 publications

The Use of Fourier Infrared Spectroscopy and Laser – Raman Spectroscopy in Bladder Malignancy Diagnosis, A comparative Study

The Use of Fourier Infrared Spectroscopy and Laser – Raman Spectroscopy in Bladder Malignancy Diagnosis, A comparative Study

Identification of hepatocellular carcinoma and paracancerous tissue based on the peak area in FTIR microspectroscopy

Human breast tissue cancer diagnosis by FT-IR spectroscopy

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