Diagnosis of Canine Atopic Dermatitis in Pugs by Intradermal Test

Characterization of the Pro-Inflammatory and Pruritogenic Transcriptome in Skin Lesions of the Experimental Canine Atopic Acute IgE-Mediated Late Phase Reactions Model and Correlation to Acute Skin Lesions of Human Atopic Dermatitis

“…Histologically, acute AD skin lesions in humans and dogs exhibit spongiosis with mild to moderate acanthosis in addition to a superficial perivascular infiltrate of lymphocytes, dendritic cells and macrophages [ 23 , 24 , 25 ]. In addition, mast cells can show degranulation, and occasionally eosinophils may be present with rare neutrophils [ 23 , 24 , 25 ].…”

“…Histologically, acute AD skin lesions in humans and dogs exhibit spongiosis with mild to moderate acanthosis in addition to a superficial perivascular infiltrate of lymphocytes, dendritic cells and macrophages [ 23 , 24 , 25 ]. In addition, mast cells can show degranulation, and occasionally eosinophils may be present with rare neutrophils [ 23 , 24 , 25 ]. Anti-canine IgE acute skin lesions in this study featured similar changes with mild acanthosis and superficial dermis expanded by mild edema, intermixed with neutrophils, eosinophils, lymphocytes, and plasma cells; eosinophils and mononuclear cells dominated the late-phase reactions at 24 h. Eosinophil recruitment to allergic inflammation sites in the skin and other tissues is driven by IL-5 signaling and by eotaxins (CCL11, CCL24, CCL26) and other chemokines such as regulated on activation, normal T cell expressed and secreted (RANTES; CCL5) and CCL3; these chemokines bind to eosinophils via the ß-chemokine receptor CCR3 [ 26 ].…”