Diagnosis of cardiovascular disease in patients with chronic kidney disease

Zoccali, Carmine; Mark, Patrick B.; Sarafidis, Pantelis; Agarwal, Rajiv; Adamczak, Marcin; Bueno de Oliveira, Rodrigo; Massy, Ziad A.; Kotanko, Peter; Ferro, Charles J.; Wanner, Christoph; Burnier, Michel; Vanholder, Raymond; Mallamaci, Francesca; Wiecek, Andrzej

doi:10.1038/s41581-023-00747-4

Cited by 28 publications

(3 citation statements)

References 117 publications

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“…Plaques, made up primarily of oxidized low-density lipoprotein cholesterol, so-called "bad" cholesterol, and miscellaneous cells which secrete destructive cytokines, narrow the small arteries of the heart such that the downstream cardiomyocytes are starved of oxygen, weakening their ability to carry out the usual workload. CAD is commonly associated with atherosclerosis of the entire systemic arterial vasculature [8,9]. CAD causes chest pain or discomfort known as angina; in many cases, it is a prelude to a heart infarction.…”

Section: Atherosclerosis and The Arterial Plaquementioning

confidence: 99%

Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure

Reiter,

Sharma,

Chuffa

et al. 2024

Life

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Cardiovascular disease is the cause of physical infirmity and thousands of deaths annually. Typically, during heart failure, cardiomyocyte mitochondria falter in terms of energy production and metabolic processing. Additionally, inflammation and the accumulation of non-contractile fibrous tissue contribute to cardiac malfunction. Melatonin, an endogenously produced molecule, experimentally reduces the initiation and progression of atherosclerotic lesions, which are often the basis of coronary artery disease. The current review critically analyzes published data related to the experimental use of melatonin to forestall coronary artery pathologies. Collectively, these studies document melatonin’s anti-atherosclerotic actions in reducing LDL oxidation and triglyceride levels, lowering endothelial malfunction, limiting adhesion molecule formation, preventing macrophage polarization to the M1 pro-inflammatory phenotype, changing cellular metabolism, scavenging destructive reactive oxygen species, preventing the proliferation and invasion of arterial smooth muscle cells into the lesioned area, restricting the ingrowth of blood vessels from the vasa vasorum, and solidifying the plaque cap to reduce the chance of its rupture. Diabetic hyperglycemia, which aggravates atherosclerotic plaque formation, is also inhibited by melatonin supplementation in experimental animals. The potential value of non-toxic melatonin as a possible inhibitor of cardiac pathology in humans should be seriously considered by performing clinical trials using this multifunctional molecule.

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Section: Atherosclerosis and The Arterial Plaquementioning

confidence: 99%

Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure

Reiter,

Sharma,

Chuffa

et al. 2024

Life

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“…Chronic kidney disease (CKD) has become an increasingly important public health priority [ 1 , 2 ]. Since 1990, the global all-age prevalence of CKD has increased by 29.3% [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of resistance exercise on patients with chronic kidney disease

Chen,

Huang,

Hua-Zhang

et al. 2024

BMC Nephrol

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Background Chronic kidney disease (CKD) has become an increasingly important public health disease with a high incidence rate and mortality. Although several studies have explored the effectiveness of resistance exercise in improving the prognosis of CKD patients, the number of studies is still limited and the results are still controversial. Objectives We conducted this meta-analysis of randomized controlled trials (RCT) studies to evaluate the effectiveness of resistance exercise on CKD patients. Methods The PubMed, Embase, and Cochrane Library databases were searched from the inception date to October 2023. The meta-analysis was conducted to evaluate 12 main indicators, including glomerular filtration rate (GFR)(ml/(min•1.73m2)), C-reactive protein (CRP) (mg/L), serum creatinine (mg/dL), hemoglobin (g/dL), Glycosylated Hemoglobin, Type A1C (HBA1c) (%), high Density Lipoprotein (HDL) (mg/dL), low Density Lipoprotein (LDL) (mg/dL), 6-min walk(m), body mass index (BMI) (kg/m2), fat-free mass (kg), fat mass (kg), grip strength (kgf). Results Sixteen RCT studies were included in this meta-analysis from 875 records. GFR exhibited no significant change in CKD patients treated with resistance exercise (WMD 1.82; 95%CI -0.59 to 4.23; P = 0.139). However, 6-min walk (WMD 89.93; 95%CI 50.12 to 129.74; P = 0.000), fat-free mass (WMD 6.53; 95%CI 1.14 to 11.93; P = 0.018) and grip strength (WMD 3.97; 95%CI 1.89 to 6.05; P = 0.000) were significantly improved with resistance exercise. The level of CRP (WMD − 2.46; 95%CI -4.21 to -0.72; P = 0.006) and HBA1c (WMD − 0.46; 95%CI -0.63 to -0.29; P = 0.000) dropped significantly after resistance exercise treatment. Conclusions Resistance exercise can improve physical function, metabolic condition, inflammatory response and cardiopulmonary function in CKD patients, specifically reflected in the increase of indicators fat-free mass, grip strength, 6-min walk, as well as the decrease of indicators HBA1c and CRP.

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“…Hypertension is a noteworthy global public health concern, with a relatively elevated prevalence of 15.4% in the elderly population (4). Unmanaged hypertension can result in severe health complications, encompassing conditions such as heart disease, stroke, renal disorders, visual impairments, among others (5)(6)(7). Early identification and intervention of hypertension are crucial.…”

Section: Introductionmentioning

confidence: 99%

Association of serum creatinine to cystatin C to waist circumference ratios and hypertension: evidence from China health and retirement longitudinal study

Yang,

Sun,

et al. 2024

Front. Endocrinol.

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BackgroundThe objective of this study was to explore the association between the ratio of serum creatinine to cystatin C to waist circumference (CCR/WC) and hypertension.MethodsThe study utilized data extracted from the China Health and Retirement Longitudinal Study. In the cross-sectional analysis, logistic regression analyses were employed to examine the association between the CCR/WC ratio and hypertension. By utilizing restricted cubic splines, potential non-linear associations between the CCR/WC ratio and hypertension were explored. In the longitudinal analysis, the association between CCR/WC quartiles (Q1–Q4) and the risk of new-onset hypertension was evaluated by Cox proportional-hazards models.ResultsIn total, 7,253 participants were enrolled. The study unveiled an inverse association with hypertension, demonstrating an odds ratio (OR) of 0.29 (95% confidence interval [CI]: 0.23–0.37, P < 0.001). Among males, an OR of 0.38 (95% CI: 0.25–0.58, P < 0.001) was observed, while among females, an OR of 0.41 (95% CI: 0.28–0.60, P < 0.001) was noted. There was an absence of a nonlinear association between the CCR/WC ratio and hypertension. Cox regression analysis unveiled a reduced risk of hypertension in Q3 (Hazard ratios [HR]: 0.69, 95% CI: 0.58–0.82, P < 0.001) and Q4: (HR: 0.70, 95% CI: 0.59–0.83, P < 0.001) in compared to the Q1 of the CCR/WC ratio, and sex-specific analysis yielded consistent results.ConclusionThis study emphasizes the potential association between an elevated CCR/WC ratio and a reduced risk of hypertension.

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Diagnosis of cardiovascular disease in patients with chronic kidney disease

Cited by 28 publications

References 117 publications

Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure

Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure

Impact of resistance exercise on patients with chronic kidney disease

Association of serum creatinine to cystatin C to waist circumference ratios and hypertension: evidence from China health and retirement longitudinal study

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