Diagnosis of Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma by Cervical Biopsy under Colposcopy and Analysis of Factors Influencing

Abstract

Objective. To explore the diagnosis of cervical intraepithelial neoplasia (CIN) and invasive cervical carcinoma (ICC) by cervical biopsy under colposcopy and analyze the factors influencing the detection. Methods. The clinical data of 134 CIN confirmed by colposcopy biopsy in our hospital from June 2018 to October 2019 and subsequent LEEP treatment were analyzed retrospectively. All patients were diagnosed pathologically after the operation. The diagnosis of CIN by cervical biopsy under colposcopy was observed. The influencing factors of CIN and ICC detected by colposcopy biopsy were analyzed by the pathological results of loop electrosurgical excision procedure (LEEP) as the gold standard. Results. After LEEP, the number of the no intraepithelial or malignant lesions (NILM) or ICC were higher than that of colposcopy biopsy, and CIN-III was lower than that of colposcopy biopsy, the differences were all statistically significant ( P < 0.05 ). Among the 134 patients, the coincidence rate between colposcopy biopsy and LEEP examination results was 79.10% (106/134), and postoperative pathological findings showed that there were 13 cases (9.70%) with the pathological upgrade and 19 cases (14.18%) with pathological decrease. Multivariate logistic analysis showed that the image quality of colposcopy image, atypical blood vessels, biopsy sampling method, and visible lesion area of the cervix were the independent influencing factors for the detection of CIN and ICC by colposcopy biopsy ( P < 0.05 ). Conclusion. CIN and ICC can be diagnosed by colposcopy cervical biopsy and postoperative histopathology. However, there are still some missed and misdiagnosed cervical biopsies under colposcopy, and the combined detection of the two can further ensure the diagnosis rate. The clinical registration number is E2018091.

Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection

“…A study reported that image quality of colposcopy images, atypical blood vessels, biopsy sampling method, and visible lesion area of the cervix were independently associated with CC after surgery for CIN3 [ 12 ]. These factors above can be subjective and dependent upon the physician’s experience.…”

“…Hence, guidelines advocate the surgical removal of CIN3 lesions [ 2 , 4 , 9 ]. Indeed, a pathological upgrade to CC can be observed after surgery in about 10-11% of the patients [ 11 , 12 ].…”

“…Still, determining in advance the patients in whom there is a greater probability of finding CC after CIN3 removal would be more conducive to improving patient outcomes by identifying patients requiring more urgent treatments. Wang et al [ 12 ] reported that image quality of colposcopy images, atypical blood vessels, biopsy sampling method, and visible lesion area of the cervix were independently associated with CC after surgery for CIN3. Some of these factors are subjective and based on the physician’s experience and judgment.…”

Retracted: Diagnosis of Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma by Cervical Biopsy under Colposcopy and Analysis of Factors Influencing

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”

“…Tis article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. Tis investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”