Diagnosis of Chronic Urticaria

Akers, William A.; Naversen, Douglas N.

doi:10.1111/ijd.1978.17.8.616

Cited by 9 publications

(3 citation statements)

References 39 publications

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“…18 The success rate for revealing a cause for chronic urticaria, even with the most diligent search, is less than 20%. 7,17,23,24 In the present study, the major etiological categories found were: allergies (12.77%), physical factors (6.20%), miscellaneous internal diseases (5.11%) and infections (2.55%). The success rate for identification of allergen(s) in acute urticaria was 20% but in chronic urticaria it was only 6%.…”

Section: Etiological Factorssupporting

confidence: 45%

Experience in Urticaria with Patients Attending a Dermatological Clinic in a Referral Center in the Eastern Province of Saudi Arabia

Uthman

El-Nuhdi

1995

Annals of Saudi Medicine

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Urticaria is a common cutaneous vascular reaction pattern caused by diverse and multiple factors. However, an etiologic factor can be established in less than 20% of chronic cases. In this study, 274 patients with urticaria were evaluated in the dermatology clinic of King Fahd Hospital of the University (KFHU) between 1989 and 1992. Saudi nationals predominated; 188 patients were males (68.6%) and 86 were females (31.4%) and the peak incidence of urticaria was in young adults. The incidence of urticaria was 3.79% of dermatological cases. The success rate for identification of etiological factors was 41% in acute urticaria and 14% in chronic urticaria. The etiological categories discovered included allergies, physical factors, infections and miscellaneous systemic factors. In conclusion, causative factors remained elusive in the majority of cases. The identification and removal of the possible causative factors is the most important aspect of management in urticaria. A detailed history and physical examination are in order; however, extensive laboratory investigations are unnecessary. Ann Saudi Med 1995;15(1):10-13. MAE Uthman, M El-Nuhd, Experience in Urticaria with Patients Attending a Dermatological Clinic in a Referral Center in the Eastern Province of Saudi Arabia. 1995; 15(1): 10-13Urticaria is a common cutaneous eruption characterized by evanescent, pruritic and slightly erythematous plaques or papules. The incidence of urticaria has been estimated to vary from 10% to 25% in the general population.1 Urticaria is a vascular reaction pattern which can be caused by multiple and diverse factors. These factors activate mast cells as well as other cells (e.g., eosinophils, basophils, neutrophils, endothelial cells and platelets) with the release of their vasoactive and chemotactic mediators of inflammation. 2,3 Histamine is the best known mediator of increased vascular permeability and itching in urticaria; however, serum factors, kinins, fibrin degradation products, leukotriens and various enzymes have also been recognized to play a pathogenic role in urticaria. 3,4 Therefore, the pathogenetic mechanism involved in urticaria can be classified as either immunological or nonimmunological reactions. 5,6 In clinical practice, an urticarial eruption can easily be diagnosed; however, finding the etiological factor(s) involved can be difficult and impossible in the majority of cases.7 To the best of our knowledge, reports of urticaria from the Middle East and in particular from Saudi Arabia are unavailable. This study was undertaken to highlight the prevalence of urticaria and to evaluate its etiological factors involved in patients referred to our dermatology clinic. Patients and MethodsWe interviewed and reviewed all patients with urticaria seen consecutively at the dermatology clinic of King Fahd Hospital of the University (KFHU) in Al-Khobar from 1989 to 1992. The number of patients forming the basis of our statistical analysis was 274 and the case records of 34 patients were excluded for either an incorrect or a ...

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Section: Etiological Factorssupporting

confidence: 45%

Experience in Urticaria with Patients Attending a Dermatological Clinic in a Referral Center in the Eastern Province of Saudi Arabia

Uthman

El-Nuhdi

1995

Annals of Saudi Medicine

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“…The treating physician has to resort to symptomatic therapy for relief of itching and suppression of wheals and flares. Regardless of the cause of the urticaria, immunologic or not [1], these symptoms and signs are likely to be induced by histamine and other mediators released from cutane ous mast cells and circulating basophils.…”

Section: Introductionmentioning

confidence: 99%

Oxatomide in the Treatment of Chronic Urticaria

et al. 1981

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Oxatomide was evaluated in a double-blind study of 35 patients with chronic urticaria. For 5 weeks patients received at random either 30 mg oxatomide b.i.d. or a placebo. Oxatomide significantly reduced not only the duration of the attacks but also the severity of erythema, lesions and itching. This lower level of suffering was clearly reflected by a diminished need for additional antiallergic medication. The overall response to treatment was rated excellent or good in 72% of the oxatomide-treated patients against only 23% of the controls which is a significant difference. Sleepiness was reported in 1 patient of each group.

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“…The management of chronic urticaria remains symptomatic in the large majority of cases, where, despite exhaustive examinations and tests, no cause can be determined [1,8], The pivotal role of histamine in the pathogenesis of urticaria underlies the extensiveness of antihistaminic prescriptions. Hi blockers of five different classes are commonly used in urticaria [8]; although each class possesses characteristic pharmacological properties, they are therapeutically interchangeable to quite a great extent.…”

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confidence: 99%

Does Mast Cell Protection plus Mediator Antagonism Surpass the Effect of a Classic Antihistaminic in the Treatment of Chronic Urticaria?

Demaubeuge

Tennstedt²,

Broux³

1982

Dermatology

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A new type of antiallergic drug, oxatomide (60 mg daily), was compared with the antihistaminic, mequitazine (10 mg daily), in a 5-week double-blind randomized study involving 26 patients with chronic urticaria. In the 13 oxatomide-treated patients, papules, erythema and pruritus were significantly suppressed after 2 weeks, which was markedly more rapid than with mequitazine. Slight somnolence was reported by 3 patients on oxatomide and 1 on mequitazine; in the latter case, severe urine retention was also reported. Another patient on mequitazine had to discontinue treatment because of severe drowsiness.

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Diagnosis of Chronic Urticaria

Cited by 9 publications

References 39 publications

Experience in Urticaria with Patients Attending a Dermatological Clinic in a Referral Center in the Eastern Province of Saudi Arabia

Experience in Urticaria with Patients Attending a Dermatological Clinic in a Referral Center in the Eastern Province of Saudi Arabia

Oxatomide in the Treatment of Chronic Urticaria

Does Mast Cell Protection plus Mediator Antagonism Surpass the Effect of a Classic Antihistaminic in the Treatment of Chronic Urticaria?

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